The Health Benefits of Natural Skin Uva Photoprotective Compounds Found in Botanical Sources (original) (raw)
Related papers
2016
In recent years, botanicals have gained importance due to their dermal photoprotective effect against the harmful UV radiation. This radiation generates reactive oxygen species which attack proteins, lipids, and nucleic acids among others. This leads to the cellular oxidation, which is reflected as tanning, skin inflammation, erythema, immunosuppression, photoaging and skin cancer. The photoprotective activity of synthetic sunscreens is unsatisfactory due the proved incomplete spectral protection, toxicity, and allergenicity. The phytotherapy treatment with antioxidant compounds with potential UV absorbing capacity could offer a more effective photoprotection since they may impede, reverse or delay the process of formation of DNA adducts. The wide diversity of botanicals with photoprotective activity is attributed to several types of substances with phenolic chromophores. These compounds can be classified as flavonoids, phytoestrogens, carotenoids, xhantophylls, coumarins, proanthocyanidins, anthocyanins, catechins, phenolic acids, triterpenes, alkaloids, etc. The bioactivity of these compounds is not limited to the photoprotective action, but antioxidant, anti-inflammatory, antimutagenic and immunomodulatory properties. The regular intake of these botanicals not only prevents but also delays the deleterious effects of sun radiation onto the skin. Therefore, these botanicals have gained considerable attention and are now included in most vitamin and cosmetic products. This review gives an overview of photoprotective botanicals mainly focused on UVA chromophores that are able to inhibit or reverse the damaging effects of sun radiation. The search criterion was made essentially on UVA photoprotective botanicals and related works published in the last ten years. The literature search included mainly the Google scholar, Science direct, and ISI web of knowledge databases.
Non-Sunscreen Photoprotection: Antioxidants Add Value to a Sunscreen
Journal of Investigative Dermatology Symposium Proceedings, 2009
The association between ultraviolet radiation (UVR) exposure and both skin cancer and photo-aging is well documented. In addition to the conventional organic-chemical and physical-mineral type sunscreens, other non-sunscreen protective strategies have been developed. These include topically applied botanical extracts and other antioxidants as well as topical DNA repair enzymes. Standard terms of photoprotection such as sun protection factor (SPF) do not accurately reflect the photoprotection benefits of these materials. For example, in spite of minimal SPF, tea extract containing polyphenols such as (À)-epigallocatechin-3-gallate (EGCG) has been shown to protect against UV-induced DNA damage and immune suppression, in part through its ability to reduce oxidative stress and inhibit NF-kB. The addition of botanical antioxidants and vitamins C and E to a broad-spectrum sunscreen may further decrease UV-induced damage compared with sunscreen alone. These agents have been shown to enhance protection against UV-induced epidermal thickening, overexpression of MMP-1and MMP-9, and depletion of CD1a þ Langerhans cells. Non-sunscreen materials such as botanical extracts, antioxidants, and DNA repair enzymes can contribute value when applied topically to human skin in vivo.
Potential of Natural Compounds as Sunscreen Agents
Pharmacognosy Reviews
Many skin diseases such as sunburn, pigmentation, wrinkles, dermatitis, urticaria, ageing, skin cancers and immune suppression are due to the extreme exposure to harmful sun radiations. The mere covering of skin through sunglasses, clothes or other external agents is not adequate protection method. Therefore, application of sunscreen is considered as one of the trendiest methods to get rid of the skin aging, sunburn and other related problem arises due to the exposure of ultraviolet radiation (UV) radiations. Sunscreen agents protect from the sun by absorbing the UV and visible sun rays. Herbs have been used in medicines and cosmetics from centuries and their potential to treat different skin diseases, to adorn and improve the skin appearance is well-known. The presented review article is concern with discussion on various plant derived chemicals acting as sunscreen agents such as squalene, peptides, and nucleotides etc and protecting mammalian skin. Herbs and herbal preparations have a high potential due to their antioxidant activity. Antioxidants such as vitamins (Vitamin C, Vitamin E), flavonoids, and phenolic acids play the main role in fighting against free radical species that are the main cause of numerous negative skin changes. Effective botanical antioxidant compounds are widely used in traditional medicine and include tocopherols, flavonoids, phenolic acids, nitrogen containing compounds (indoles, alkaloids, amines, and amino acids), and monoterpenes. Anthocyanin's, Proanthocyanidin, Quercetin, Anthranilate, Resveratrol, Apigenin, Silymarin, Curcumin, Carotenoids are well known plant derived active chemicals that have potential to absorb radiations. This review covers all essential aspects of potential of herbs as radioprotective agents and its prospects.
Photoprotective potential in some medicinal plants used to treat skin diseases in Sri Lanka
BMC Complementary and Alternative Medicine, 2016
Background: The constant exposure to solar ultraviolet radiation (UV) has a variety of harmful effects on human health. Although synthetic sunscreen products have been introduced as a preventive/therapeutic strategy, with the realization of their adverse side effects, the recent trend is to search for human friendly alternative formulations especially of plant origin. Therefore, the present study focuses on evaluation of photoprotective activity of aqueous extracts (1 mg/ml) of eleven medicinal plants in Sri Lanka that have been widely employed in traditional medicine as treatment options for various skin diseases and to improve the complexion. Methods: For the determination of UV filtering potential of the extracts, UV absorption was measured and the sun protection factor (SPF) was calculated according the Mansur equation. The antioxidant activity was evaluated by DPPH and ABTS assays.
Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation
Frontiers in Pharmacology, 2018
Human skin exposed to solar ultraviolet radiation (UVR) results in a dramatic increase in the production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural balance toward a pro-oxidative state, resulting in oxidative stress. The detrimental effects of oxidative stress occur through multiple mechanisms that involve alterations to proteins and lipids, induction of inflammation, immunosuppression, DNA damage, and activation of signaling pathways that affect gene transcription, cell cycle, proliferation, and apoptosis. All of these alterations promote carcinogenesis and therefore, regulation of ROS levels is critical to the maintenance of normal skin homeostasis. Several botanical products have been found to exhibit potent antioxidant capacity and the ability to counteract UV-induced insults to the skin. These natural products exert their beneficial effects through multiple pathways, including some known to be negatively affected by solar UVR. Aging of the skin is also accelerated by UVR exposure, in particular UVA rays that penetrate deep into the epidermis and the dermis where it causes the degradation of collagen and elastin fibers via oxidative stress and activation of matrix metalloproteinases (MMPs). Because natural compounds are capable of attenuating some of the UV-induced aging effects in the skin, increased attention has been generated in the area of cosmetic sciences. The focus of this review is to cover the most prominent phytoproducts with potential to mitigate the deleterious effects of solar UVR and suitability for use in topical application.
Phytochemicals as protectors against ultraviolet radiation: versatility of effects and mechanisms
Planta medica, 2008
Ultraviolet (UV) radiation is one of the most abundant carcinogens in our environment, and the development of non-melanoma skin cancers, the most common type of human malignancy worldwide, represents one of the major consequences of excessive exposure. Because of growing concerns that the level of UV radiation is increasing as a result of depletion of the stratospheric ozone and climate change, the development of strategies for protection of the skin is an urgent need. Many phytochemicals that belong to various families of secondary metabolites, such as alkaloids (caffeine, sanguinarine), flavonoids [(-)-epigallocatechin 3-gallate, genistein, silibinin], carotenoids ( beta-carotene, lycopene), and isothiocyanates (sulforaphane), offer exciting platforms for the development of such protective strategies. These phytochemicals have been consumed by humans for many centuries as part of plant-rich diets and are presumed to be of low toxicity, an essential requirement for a chemoprotectiv...
Plant extracts and natural compounds used against UVB-induced photoaging
Biogerontology, 2017
Skin is continuously exposed to a variety of environmental stresses, including ultraviolet (UV) radiation. UVB is an inherent component of sunlight that crosses the epidermis and reaches the upper dermis, leading to increased oxidative stress, activation of inflammatory response and accumulation of DNA damage among other effects. The increase in UVB radiation on earth due to the destruction of stratospheric ozone poses a major environmental threat to the skin, increasing the risk of damage with long-term consequences, such as photoaging and photocarcinogenesis. Extracts from plants and natural compounds have been historically used in traditional medicine in the form of teas and ointments but the effect of most of these compounds has yet to be verified. Regarding the increasing concern of the population with issues related to quality of life and appearance, the cosmetic market for anti-aging and photoprotective products based on natural compounds is continuously growing, and there is increasing requirement of expansion on research in this field. In this review we summarized the most current and relevant information concerning plant extracts and natural compounds that are able to protect or mitigate the deleterious effects caused by photoaging in different experimental models.
Sunscreens and Antioxidants as Photo-protective Measures: An update
Our Dermatology Online, 2013
There are many photo-protective measures adopted for protection from the solar radiation especially the UV radiation spectrum, sunscreens being the main agents. Besides the traditional approach of topical use of sunscreens, both chemical and physical, a new approach has emerged to use systemic agents in the form of vitamins and minerals. In this review, we are describing the major aspects related to sunscreens and anti-oxidants as photo-protective measures.
Herbal Photoprotective Formulations and their Evaluation
Photochemoprevention has become an important armamentarium in the fight against ultraviolet radiation induced damage to the skin. UV irradiation to skin results in erythema, edema, sunburn cells, hyperplasia, immunosuppression, photoaging and photocarcinogenesis. Various synthetic agents have been used as photoprotectives but they have limited use because of their potential toxicity in humans and their ability to interfere only in selected pathways of multistage process of carcinogenesis. Several botanical compounds have been shown to be antimutagenic, anticarcinogenic and nontoxic and have ability to exert striking inhibitory effects on a plethora of cellular events at various stages of carcinogenesis. Since multiple pathways are involved in photocarcinogenesis so mixture of several botanical antioxidants working through various mechanisms, in conjunction with the use of sunscreens could also be an effective approach for reducing photoaging and skin cancer in humans. The performance of sunscreen substances could be improved by modification of their chemical, physical and technological properties or by the use of novel carriers like liposomes, nanoparticles, phytosomes, transferosomes, nanospheres etc. The application of novel approaches can also improve its efficacy regarding continuous action of herbs on the human body. This review will focus on list of herbs, formulations and evaluation parameters of photoprotective herbs.
Herbal photo actives for skin protection from harmful radiation
AIP Conference Proceedings, 2023
Solar radiation with UVA (320-400 nm) and UVB (290-320 nm) wavelengths can cause considerable harm, particularly to the skin. On the one hand, sunlight is necessary for the production of Vitamin D, yet long-term exposure to it can cause everything from sunburn to skin cancer. UV rays create dangerous molecules known as free radicals or reactive oxygen species (ROS), which cause skin cancer and premature ageing. Herbal formulations and extracts have long been used as sunscreen for photo protection and are thought to be more appropriate than allopathic topical medicines due to their complex composition and high sun protection factor or SPF value. Vitamins C, E, and flavonoid-rich herbs not only have antioxidant properties, but they also have a great ability to protect against UV-induced skin responses. Whole plant extracts such as Aniba canelilla, Calendula officinalis, Arrabidaea chica, Euphorbia tirucalli, and isolated compounds such as Pycnogenol, Apigenin, Resveratrol, quercetin, Sinapoyl malate, and Essential oils such as Red Raspberry Seed Oil, Carrot Seed Oil, Peppermint Oil, and others are the first choice in the current scenario. This review includes a detailed overview on skin damage and its protection with different available photo protective and cosmeceuticals.