Application of Amorphous Indium Gallium Zinc Oxide Thin Film Transistor Biosensors in Creatine Kinase Detection (original) (raw)
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Applied Physics Letters, 2010
The effects of zinc concentration on the performance of solution processed amorphous indium gallium zinc oxide ͑a-IGZO͒ thin film transistors ͑TFTs͒ have been investigated using high-k aluminum titanium oxide as gate dielectric. The x-ray diffraction results confirmed that all the IGZO channel layers are amorphous. The performance of a-IGZO TFTs were investigated in the linear regime operation. Highest linear field-effect mobility of 5.8 cm 2 / V s with an I on / I off ratio of 6 ϫ 10 7 and subthreshold swing of 0.28 V/dec were obtained for the a-IGZO ͑311͒ TFTs. The obtained performance of the a-IGZO TFTs is very promising for low-voltage display applications.
Scientific Reports, 2022
Point-of-care devices are expected to play very critical roles in early diagnosis and better treatment of cancer. Here, we report the end-to-end development of novel and portable biosensors for detecting carcinoembryonic antigen (CEA), a cancer biomarker, almost instantly at room temperature. The device uses reduced graphene oxide (rGO) as the base conducting layer and a novel poly[(1,4-phenylene)-alt-(3,6-(1,2,4,5-tetrazine)/3,6-(1,2,4,5-dihydrotetrazine))] (PhPTz) as an immobilizing matrix for the CEA antibodies. Judiciously introduced nitrogen-rich semiconducting PhPTz brings multiple advantages to the device—(1) efficiently immobilizes anti-CEA via synergistic H-bonding with peptide and N-glycal units and (2) transports the charge density variations, originated upon antibody-antigen interactions, to the rGO layer. The CEA was dropped onto the anti-CEA/PhPTz/rGO devices at ambient conditions, to facilitate binding and the change in current flowing through the sensors was measured...
Materials
Immunoglobulin G (IgG), a type of antibody, represents approximately 75% of serum antibodies in humans, and is the most common type of antibody found in blood circulation. Consequently, the development of simple, fast and reliable systems for IgG detection, which can be achieved using electrochemical sandwich-type immunosensors, is of considerable interest. In this study we have developed an immunosensor for human (H)-IgG using an inexpensive and very simple fabrication method based on ZnO nanorods (NRs) obtained through the electrodeposition of ZnO. The ZnO NRs were treated by electrodepositing a layer of reduced graphene oxide (rGO) to ensure an easy immobilization of the antibodies. On Indium Tin Oxide supported on Polyethylene Terephthalate/ZnO NRs/rGO substrate, the sandwich configuration of the immunosensor was built through different incubation steps, which were all optimized. The immunosensor is electrochemically active thanks to the presence of gold nanoparticles tagging th...
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International Journal of Electrochemical Science, 2013
The development of biosensors has seen recent growth owing to their wide range of potential applications from the defending of bioterrorism to the detection of various diseases. Recent investigations in highly sensitive nanomaterials containing nanotechnology suggest the possibility of its advanced applications as biosensors in different biomedical fields. Besides highlighting the characteristic features of different classes of advanced biosensor across different fields of potential application, this article gives a clear overview of some specific investigations related to the surface immobilizations of piezoelectric biosensors employing effective materials and advanced technologies. Further, the current development of piezoelectric biosensors in the detection of potential biomolecules for advanced biomedical applications is critically reviewed. The qualitative and quantitative sensitivity of piezoelectric biosensors, various expressions of resonant frequency shift with changes in mass, thickness, density, and stress for piezoelectric materials are distinctly explored. The importance of several novel nanomaterials for the detection of various diseased biomolecules is clearly illustrated. This study concludes that proper selection of materials is potential to bring improvement in quality as well as reduction in cost of advanced biosensor devices. © 2013 by ESG. http://electrochemsci.org/papers/vol8/80608863.pdf
Nanoscale Research Letters, 2017
The combination of advantages of using zeolites and gold nanoparticles were aimed to be used for the first time to improve the characteristic properties of ion selective field-effect transistor (ISFET)-based creatinine biosensors. The biosensors with covalently cross-linked creatinine deiminase using glutaraldehyde (GA) were used as a control group, and the effect of different types of zeolites on biosensor responses was investigated in detail by using silicalite, zeolite beta (BEA), nano-sized zeolite beta (Nano BEA) and zeolite BEA including gold nanoparticle (BEA-Gold). The presence of gold nanoparticles was investigated by ICP, STEM-EDX and XPS analysis. The chosen zeolite types allowed investigating the effect of aluminium in the zeolite framework, particle size and the presence of gold nanoparticles in the zeolitic framework. After the synthesis of different types of zeolites in powder form, bare biosensor surfaces were modified by drop-coating of zeolites and creatinine deiminase (CD) was adsorbed on this layer. The sensitivities of the obtained biosensors to 1 mM creatinine decreased in the order of BEA-Gold > BEA > Nano BEA > Silicalite > GA. The highest sensitivity belongs to BEA-Gold, having threefold increase compared to GA, which can be attributed to the presence of gold nanoparticle causing favourable microenvironment for CD to avoid denaturation as well as increased surface area. BEA zeolites, having aluminium in their framework, regardless of particle size, gave higher responses than silicalite, which has no aluminium in its structure. These results suggest that ISFET biosensor responses to creatinine can be tailored and enhanced upon carefully controlled alteration of zeolite parameters used to modify electrode surfaces.