Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor (original) (raw)
Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl
Giovanni Monaco
Cell Death and Differentiation, 2012
View PDFchevron_right
Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals
Llewelyn Roderick
Molecular cell, 2008
View PDFchevron_right
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Andreas Strasser
Nature Reviews Molecular Cell Biology, 2013
View PDFchevron_right
Targeting Bcl-2 Family of Proteins: An Important Strategy in Cancer Therapeutics
RAKESH R SOMANI
View PDFchevron_right
BCL-2 protein family: attractive targets for cancer therapy
deeksha kaloni
Apoptosis
View PDFchevron_right
Unlocking the Therapeutic Potential of BCL-2 Associated Protein Family: Exploring BCL-2 Inhibitors in Cancer Therapy
Yasser Bustanji
Biomolecules & therapeutics, 2024
View PDFchevron_right
Apoptosis regulation by Bcl-x L modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating
Horia Vais
Proceedings of the National Academy of Sciences, 2007
View PDFchevron_right
The Bcl-2 Protein Family Member Bok Binds to the Coupling Domain of Inositol 1,4,5-Trisphosphate Receptors and Protects Them from Proteolytic Cleavage
Thomas Kaufmann
Journal of Biological Chemistry, 2013
View PDFchevron_right
IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2
Giovanni Monaco, R. La Rovere, Kirsten Welkenhuyzen, Jan Parys
2013
View PDFchevron_right
New dimension in therapeutic targeting of BCL-2 family proteins
Samaher BESBES
Oncotarget, 2015
View PDFchevron_right
Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context
Bristi Paul
View PDFchevron_right
Apoptosis regulator BCL-2 | 63
Piret Hussar
2016
View PDFchevron_right
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy
Martin Dyer
Cell Death and Differentiation, 2009
View PDFchevron_right
Structure-Based Discovery of An Organic Compound That Binds Bcl-2 Protein and Induces Apoptosis of Tumor Cells
Jiacheng Wang
Proceedings of the …, 2000
View PDFchevron_right
Breast Cancer Cells Can Evade Apoptosis-Mediated Selective Killing by a Novel Small Molecule Inhibitor of Bcl-2
Zaneta Nikolovska-Coleska
Cancer Research, 2004
View PDFchevron_right
Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer
Brona Murphy
Experimental oncology, 2012
View PDFchevron_right
RECORDS OF PHARMACEUTICAL AND BIOMEDICAL SCIENCES Insights into Novel Drugs Targeting Bcl-2 Protein as Potential Anti- cancer Agents
safaa kishk
2020
View PDFchevron_right
Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives
Mohamed Rahmani
Cancers, 2021
View PDFchevron_right
Anti-apoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity
Rens Braster
Blood, 2014
View PDFchevron_right
Apoptosis: Bcl-2-related proteins get connected
Michael D Jacobson
Current Biology, 1997
View PDFchevron_right
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
Llewelyn Roderick
Proceedings of the …, 2009
View PDFchevron_right
An inhibitor of Bcl2 family proteins induces regression of solid tumours
Letai Le
Nature, 2005
View PDFchevron_right
Bcl-xL Acts as an Inhibitor of IP3R Channels, Thereby Antagonizing Ca2+-Driven Apoptosis
Nicolas Rosa
View PDFchevron_right
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
Mohammad Ola
Molecular and cellular biochemistry, 2011
View PDFchevron_right
Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins
Arnold Satterthwait
Cell Death and Differentiation, 2006
View PDFchevron_right
The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effect
Martin Bootman, Clark Distelhorst
Cell Calcium, 2008
View PDFchevron_right
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
Christopher Dillon
Proceedings of the National Academy of Sciences of the United States of America, 2008
View PDFchevron_right
Modulating Mitochondria-Mediated Apoptotic Cell Death through Targeting of Bcl-2 Family Proteins
agnes cibiel
Recent Patents on DNA & Gene Sequences, 2007
View PDFchevron_right
Amphipathic Tail-anchoring Peptide and Bcl-2 Homology Domain-3 (BH3) Peptides from Bcl-2 Family Proteins Induce Apoptosis through Different Mechanisms
Jae-Kyun Ko
Journal of Biological Chemistry, 2010
View PDFchevron_right
The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1a to Bad
alphonse garcia
Eur J Immunol, 2002
View PDFchevron_right
Role of Bcl-2 family of proteins in malignancy
Belinda Baliga
Hematological Oncology, 2002
View PDFchevron_right