Mucoepidermoid variant of adenosquamous carcinoma arising in ovarian dermoid cyst: a case report and review of the literature (original) (raw)
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Squamous Cell Carcinoma Arising in a Dermoid Cyst Ovary: A Rare Case Report
2016
Dermoid cysts account for approximately 25% of all ovarian tumors. Presence of pure squamous cell carcinoma is very rare findings (1-2%), which is attributable to malignant transformations into a pre-existing dermoid cyst. As there are no specific signs and symptoms to suggest malignancy in dermoid cyst, therefore it is difficult to predict, and most cases are diagnosed post-operatively. We hereby report a case of dermoid cyst ovary with malignant transformation into squamous cell carcinoma in 50 years post-menopausal women. Who presented with complaint of abdominal pain and increased frequency of micturation. Hysterectomy with Bilateral-salpingo-oophorectomy (BSO) with omentectomy was done. Right ovary showed huge cyst with hair shaft, sebaceous materials and a small solid area. Histopathological examination revealed squamous cell carcinoma was arising within the dermoid cyst.
Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?
Modern Pathology
Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC) have overlapping histopathological appearances and sites of occurrence, which may cause diagnostic difficulty impacting subsequent treatment. We conducted a systematic review of the scientific literature to determine whether molecular alterations were sufficiently different in MEC and ASC to aid in classifying the two entities. We searched Medline, Embase and Web of Science for studies reporting molecular determinations of ASC and/or MEC and screened retrieved records for eligibility. Two independent researchers reviewed included studies, assessed methodological quality and extracted data. Of 8623 identified records, 128 articles were included for analysis: 5 which compared the two tumors in the same investigation using the same methods and 123 which examined the tumors separately. All articles, except one were case series of moderate to poor methodological quality. The 5 publications examining both tumors showed that ...
Human Pathology, 2012
Dermoid cysts are common benign ovarian germ cell neoplasms. Occasionally, one of the mature elements undergoes malignant transformation resulting in the formation of a somatic malignancy; most commonly this is squamous carcinoma. We report a unique case where 2 separate malignancies arose within a dermoid cyst, one a signet ring mucinous adenocarcinoma and the other a pulmonary-type adenocarcinoma. There have been only occasional earlier case reports of a possible pulmonary-type adenocarcinoma arising in a dermoid cyst. In the case we report, the pulmonary-type adenocarcinoma was closely associated with a bronchial structure and exhibited diffuse positive immunohistochemical staining with TTF1, PE10, and napsin A. Molecular studies revealed no evidence of epidermal growth factor receptor mutation, a molecular alteration which may be found in primary pulmonary adenocarcinoma.
Coexistence Of Squamous Cell CarcinomaWith Dermoid Cyst Of Ovary:A Case Report
Ovarian squamous cell carcinoma is a rare malignancy and the occurrence is attributable to malignant transformation of an existing ovarian dermoid cyst. The de novo occurrence of squamous cell carcinoma of the ovary, in the absence of an antecedent ovarian dermoid, is extremely rare. A 40-years-old female presented with pain and enlargement of abdomen since last 4 months. A mass was felt over right iliac fossa. Ultrasonography showed partly cystic and solid area in mass arising from ovary. A tooth-like structure was also seen. Dermoid cyst was the diagnosis offered. Laparotomy was performed. Ovarian mass with hair, a tooth and putty-like material was present. Solid white area with thickened wall was found. Histopathology confirmed the findings of dermoid cyst and the thickened area showed squamous cell carcinoma with areas showing keratinous and giant cell reaction which was also seen at the periphery of tumor areas. Left ovary was normal and no deposits of tumor were seen. Postoperative period was uneventful.
Intra-Cystic (In Situ) Mucoepidermoid Carcinoma: A Clinico-Pathological Study of 14 Cases
2020
Aims: To report on the clinico-pathological features of a series of 12 intra-oral mucoepidermoid carcinomas showing exclusive intra-cystic growth. Methods and methods: All mucoepidermoid carcinomas diagnosed in the period 1990-2012 were retrieved, the original histological preparations were reviewed to confirm the diagnosis, and from selected cases, showing exclusive intra-cystic neoplastic component, additional sections were cut at 3 subsequent 200m intervals and stained with Hematoxylin-Eosin, PAS and Alcian Blue, to possibly identify tumor invasion of the adjacent tissues, which could have been overlooked in the original histological preparations. Also, pertinent findings collected from the clinical charts and follow-up data were analyzed. Results: We identified 14 intraoral mucoepidermoid carcinomas treated by conservative surgery and with a minimum follow up of 5 years. The neosplasm were located in the hard palate (9 cases), the soft palate (2), the cheeck (2) and the retromo...
Squamous cell carcinoma arising in a dermoid cyst of the ovary: A case series
Bangladesh Medical Research Council Bulletin
Background: Malignant transformation in a dermoid cyst of the ovary is a rare complication, occurring in only 1-2% of cases, with squamous cell carcinoma being the most common type. Preoperative diagnosis is difficult because of the lack of specific symptoms and signs to suggest malignancy. The prognosis is generally poor when disease has spread beyond the ovary. Objective: This study was conducted to review experience with this disease and describe the current treatment modality. Methods: It was identified 4 women with this diagnosis during 2013-2018. This is a descriptive study, looking at the patient’s characteristics, mode of presentation, the role of tumor markers and radiological imaging in diagnosis. It was also examined the stage and pathological features of the presentation and subsequent course of the disease. Result: The median age was 45 (range: 32-63 yrs). Three cases were stage I and one case was stage III. The average tumor diameter was 14.1cm. All patients were und...
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2016
Oncocytic mucoepidermoid carcinoma (OMEC) is a very rare variant of mucoepidermoid carcinoma, which is usually described in literature as a low-grade cystic lesion. High-grade lesions have also been described but a thorough search of literature did not show any reported case with lymph node metastasis. Here, we present the case of a 65-year-old male with an asymptomatic slow growing neck mass for nine months. The resected tumor revealed a circumscribed mass with solid and cystic areas with large cervical lymph nodes. Histopathological examination showed oncocytic cell predominance with areas of squamoid and mucinous differentiation. Four lymph nodes were found to be positive. Periodic acid-Schiff, mucicarmine and alcian blue stains were positive. P63, which has recently been suggested as a reliable marker for OMEC, showed diffuse strong positivity. This variant is important because of its rarity and high chances of misdiagnosis. The use of ancillary technique is important in the diagnosis of this rare entity.
A cytohistologic correlation of mucoepidermoid carcinoma: emphasizing the rare oncocytic variant
Pathology research international, 2011
It is well-known that the morphological variability of mucoepidermoid carcinoma (MEC) of the salivary glands may lead to interpretative difficulties on fine-needle aspiration (FNA) diagnosis. In this study we identify morphologic features that may be useful in the FNA diagnosis of MEC. The cohort included 23 cases of MEC; cytology and histology slides were reviewed and assessed for % cystic component, extracellular mucin, mucous and intermediate cells, oncocytes, cells with foamy/clear cytoplasm, keratinized cells and lymphocytes. On FNA 12/23 (52%) cases were diagnosed as consistent with or suggestive of MEC; 6/23 (26%) as salivary gland neoplasm and 5/23 (22%) as no tumor seen. The cystic component was ≥50% in 18/23 (78%) and <50% in 5 cases. The features prevalent in FNA and histology were: mucous cells (96% and 91%), extracellular mucin (91% both), intermediate cells (100 and 83%), lymphocytes (96 and 78%) and cells with foamy/clear cytoplasm (74% both). Oncocytes were seen i...