original ) (raw )Subtle changes in endochin-like quinolone (ELQ) structure alter site of inhibition within the cytochrome bc 1 complex of Plasmodium falciparum
David Fidock
Antimicrobial Agents and Chemotherapy, 2015
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Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling
David Rodrigues da Rocha
Memórias do Instituto Oswaldo Cruz, 2017
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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
raman sharma
Proceedings of the National Academy of Sciences of the United States of America, 2012
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2D, 3D-QSAR and molecular docking of 4(1H)-quinolones analogues with antimalarial activities
Thulie Paulinne Jimenez Villalobos
Journal of Molecular Graphics and Modelling, 2013
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HDQ, a Potent Inhibitor of Plasmodium falciparum Proliferation, Binds to the Quinone Reduction Site of the Cytochrome bc1 Complex
Paul Oneill
Antimicrobial Agents and Chemotherapy, 2012
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Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits
Daniel J V A dos Santos
Mol. Inf., 2013
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Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1
Svetlana Antonyuk
Proceedings of the National Academy of Sciences of the United States of America, 2015
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Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)
Paul Oneill
Journal of Medicinal Chemistry, 2012
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Potent Antimalarial 2-Pyrazoyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-Like Properties
Svetlana Antonyuk
ACS Medicinal Chemistry Letters
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In silico Anti-malaria Activity of Quinolone Compounds against Plasmodium falciparum Dihydrofolate Reductase (pfDHFR)
Oluwatosin Saibu
International Journal of Biochemistry Research & Review
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A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor
Case McNamara , Badry Bursulaya
ACS Chemical Biology, 2011
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Targeted Structure–Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis
Stone Doggett
ACS Infectious Diseases, 2018
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Novel Conjugated Quinoline–Indoles Compromise Plasmodium falciparum Mitochondrial Function and Show Promising Antimalarial Activity
Jonathan Baell
Journal of Medicinal Chemistry, 2013
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Molecular Dynamics, Inhibitive, Structural Activity, and Toxicity Studies of Novel 4-aminoquinoline Imidazole Analogues Against Chloroquine-Resistant-Plasmodium falciparum (3D7 strain)
Taofeek Saliu
Research Square (Research Square), 2023
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Cytochrome b Mutations That Modify the Ubiquinol-binding Pocket of the Cytochrome bc1 Complex and Confer Anti-malarial Drug Resistance in Saccharomyces cerevisiae
Philip Hill
Journal of Biological Chemistry, 2005
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Structural requirements of 3-carboxyl-4(1H)-quinolones as potential antimalarials from 2D and 3D QSAR analysis
Paola Gramatica
Journal of Molecular Graphics and Modelling, 2013
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Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors
Kevin J Galinsky
The Journal of infectious diseases, 2015
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A Quest for New Antimalarial Agents with Improved Specificity Guided by Molecular Docking, 3D QSAR and Molecular Dynamics Simulation Studies
Vijjulatha Manga
Asian Journal of Chemistry, 2018
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Structure–activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum
Victor Melendez
Bioorganic & Medicinal Chemistry Letters, 2010
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Binding of Quinoline-Based Inhibitors to Plasmodium falciparum Lactate Dehydrogenase: A Molecular Docking Study
Jeremy Eberle
Open Journal of Biophysics, 2013
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Antimalarial quinolones: Synthesis, potency, and mechanistic studies
Rozalia Dodean , David Hinrichs
Experimental Parasitology, 2008
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Structure-based de novo design, molecular docking and molecular dynamics of primaquine analogues acting as quinone reductase II inhibitors
Andre Pimentel
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Discovery, Synthesis, and Optimization of Antimalarial 4(1H)-Quinolone-3-Diarylethers
Sovitj Pou
Journal of Medicinal Chemistry, 2014
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Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as Pf eEF2
Irene Hallyburton
ChemMedChem, 2022
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QSAR, molecular docking and ADMET studies of quinoline, isoquinoline and quinazoline derivatives against Plasmodium falciparum malaria
EL RHABORI Said , Khalil Fouad
Structural Chemistry
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