A meta-analysis of effects of vitamin E supplementation alone and in combination with omega-3 or magnesium on polycystic ovary syndrome (original) (raw)
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Scientific Reports
Polycystic ovary syndrome (PCOS) is a common endocrinopathy among reproductive-age women. Various therapeutical approaches are currently used to manage or control symptoms associated with PCOS. This systematic review intended to assess the effects of Vit E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers, and hormonal functions in PCOS women based on the clinical trial's results. The databases including PubMed, Scopus, Cochrane, Web of Science, and Embase were used to find all relevant studies. The authors reviewed all relevant clinical trials via systematic evaluation of abstracts and titles. Searches were conducted on August 1, 2020. After the initial search and reading of the article's title and abstract, 353 articles were reviewed; finally, 12 articles met the inclusion criteria. Vitamin E supplementation improves lipid profile, decreases insulin and HOMA-IR levels. Furthermore, while Vitamin E supplementation decreases LH and testoster...
Vol 15, No 1, January-March , Pages: 44-50, 2021
Background: Angiogenesis disturbances are common in women with polycystic ovary syndrome (PCOS). Vitamin E has antiangiogenic properties. Data on the effects of vitamin E on angiogenesis in PCOS is limited, so the current study was conducted to evaluate its effects on angiogenic indices in PCOS patients. Materials and Methods: This randomized, double-blind, placebo-controlled trial was performed on 43 women aged 20-40 years, diagnosed with PCOS (Rotterdam criteria). It was performed at the referral clinic affiliated to Tabriz University of Medical Sciences, Tabriz, Iran, from April 2017 to September 2017. Patients were randomly assigned into two groups to receive either 400 IU/day vitamin E -as alpha tocopheryl acetate- (n=22) or placebo (n=21), for 8 weeks. Anthropometric, and angiogenic parameters including body weight, fat mass and fat free mass, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiopoietin-1 (Ang- 1), and angiopoietin-2 (Ang-2) were measured by standard methods at the beginning and at the end of study. Statistical Package for Social Science version 25 was used for statistical analysis and P<0.05 were considered significant. Results: After adjusting for potential confounders, we observed that vitamin E supplementation significantly reduced body weight, fat mass, Ang-1, Ang-1/Ang-2 ratio and VEGF (P<0.01). We did not observe any considerable effect for vitamin E on Ang-2 level or bFGF. Conclusion: Vitamin E supplementation for 8 weeks in the PCOS women had beneficial effects on body weight, Ang- 1, Ang-1/Ang-2 ratio, and VEGF level (Registration number: IRCT201610193140N18).
Dietary Total Antioxidant Capacity and Risk of Polycystic Ovary Syndrome: A Case-Control Study
Int J Fertil Steril, Vol 16, No 3, July-September , 2022
Background: Among multiple factors that affect the etiology of polycystic ovary syndrome (PCOS), diet has an important contribution. Chronic oxidative stress has also been implicated in the development of PCOS. The present study is an attempt to evaluate dietary total antioxidant capacity (TAC) and its relationship with odds of PCOS in Iran. Materials and Methods: The study was carried out as a case-control study in hospital outpatient clinics, Tehran, Iran. Totally, 310 female participants with a history of PCOS and 602 age-matched controls took part in this study between June 2015 and December 2018. A reproducible and valid 168-item semi-quantitative food frequency inventory was utilized to determine the entire antioxidants of the usual diet in order to calculate dietary TAC. The relationship of dietary TAC with odds of PCOS were assessed adjusting for potential confounders through an estimation of two multivariable conditional regression models. The first tertile was presented as a reference category. Results: In a fully adjusted model, the highest tertile of dietary TAC was associated with a reduced odds of PCOS [odds ratio (OR): 0.81, 95% confidence interval (95% CI): 0.59, 0.96, P for trend: 0.038). In addition, PCOS odds decreased in the highest tertile of α-tocopherol intake (OR: 0.73, 95% CI: 0.56, 0.88, P for trend: 0.023). The adjusted ORs in the highest tertile of vitamin C, β-carotene and magnesium were 0.79 (95% CI: 0.83-0.97), 0.81 (95% CI: 0.67-0.98) and 0.91 (95% CI: 0.55-0.98) respectively, with a significant trend. Conclusion: Our results provide evidence that there was a relationship between high TAC diets and lower odds of PCOS.
DergiPark (Istanbul University), 2021
Polycystic ovary syndrome (PCOS) is a heterogeneous disease characterized by metabolic and endocrine disorders, especially in women of reproductive age, and the criteria of "oligo-ovulation or anovulation", "clinical or biochemical findings of hyperandrogenism" and "polycystic ovaries" are used for diagnosis. PCOS is associated with inflammatory diseases such as obesity, Type 2 DM, cardiovascular disease and insulin resistance. Studies have shown that monounsaturated fatty acids (omega 9), polyunsaturated fatty acids omega 3, vitamin D, vitamin E, curcumin, cinnamon, fennel and flaxseed supplements, high-protein diets and exercise can reduce the complications of PCOS and can be effective in the treatment of PCOS. In this review, nutritional supplements and lifestyle changes that can be made in the reduction or treatment of PCOS complications will be examined with scientific reality.
Nutrients, 2021
Polycystic ovary syndrome (PCOS) affects several reproductive and endocrine features in females and has a poorly understood etiology. Treatment strategies for PCOS are limited and are based primarily on diet and nutrient supplementation. Recent studies have recommended some nutrients such as vitamins, minerals and vitamin-like nutrients for the therapy for PCOS. Therefore, it is claimed that the cause of PCOS could be vitamin or mineral deficiency. This review provides a narrative on the effect of nutritional supplementation on oxidative stress induced in PCOS. Oxidative stress plays a formative role in PCOS pathophysiology. This article reviews oxidative stress, its markers, nutritional supplementation and clinical studies. We also aim to show the effect of nutritional supplementation on genes affecting hormonal and glucose-mediated pathways.
Comparison of dietary micronutrient intake in PCOS patients with and without metabolic syndrome
Journal of Ovarian Research, 2021
Background Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. It is one of the risk factors of metabolic syndrome (MetS). These two syndromes have an inflammatory etiologic foundation along with oxidative stress. The present study aimed to compare the dietary intake of antioxidant micronutrients in PCOS women with and without MetS. Materials and methods Overall, 42 participants eligible for this nested case control study were selected by the convenience sampling method. The case group included 14 PCOS patients with MetS and the control group included 28 PCOS patients without MetS. The dietary intake assessment of selenium, chromium, zinc, carotenoids, vitamin D and vitamin E was carried out by a 147-item Food Frequency Questionnaire (FFQ). PCOS and MetS were diagnosed using the Rotterdam criteria and NCEP ATP III, respectively. Statistical analysis was performed using SPSS16 software, T-test and Mann Whitney. Significant P-value was c...
Journal of affective disorders, 2018
The aim of this study was to evaluate the effects of omega-3 and vitamin E co-supplementation on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome (PCOS). Forty PCOS women were allocated into two groups and treated with 1000mg omega-3 fatty acids plus 400 IU vitamin E supplements (n = 20) or placebo (n = 20) per day for 12 weeks. Parameters of mental health were recorded at baseline and after the 12-week intervention. Gene expression related to insulin and inflammation were measured in blood samples of PCOS women. After the 12-week intervention, compared with the placebo, omega-3 and vitamin E co-supplementation led to significant improvements in beck depression inventory total score (- 2.2 ± 2.0 vs. - 0.2 ± 1.3, P = 0.001), general health questionnaire scores (- 5.5 ± 4.6 vs. - 1.0 ± 2.3, P < 0.001) and depression anxiety and stress scale scores (- 7.2 ± 5.2 vs. - 1.3 ± 1.3, P < 0.001). Compared with...
Indian Journal of Obstetrics and Gynecology Research, 2022
Polycystic ovary syndrome (PCOS) a heterogeneous disorder, characterized by hyperandrogenism, chronic anovulation, obesity, and insulin resistance (IR). Studies have demonstrated the beneficial effect of vitamin D supplementation on insulin resistance in PCOS. Aim: To find the difference of vitamin D level between the PCOS and control groups. And to correlate serum 25(OH)D concentration and metabolic risk factors in PCOS women. Materials and Methods: 49 women, diagnosed with PCOS were recruited as cases and another 49 women without PCOS served as controls. Demographic data like age, BMI, menstrual pattern, clinical features like hirsuitism, acne were recorded for both cases and control. The serum 25(OH)D and metabolic markers were measured. The primary outcome was the difference in vitamin D status between the cases and controls, the secondary outcomes were correlations between serum 25(OH)D concentration and metabolic risk factors in women with PCOS. Results: Vitamin D level was significantly lower in cases than in controls (P < 0.05). The prevalence of IR was significantly greater in the Vitamin D deficiency group among cases (P < 0.05), but not so for BMI and fasting insulin. Also, prevalence of obesity and deranged lipid profile was not significantly increased in the vitamin D deficiency group of PCOS patients. Conclusions: Vitamin D deficiency is prevalent in PCOS women in Eastern India, especially in those with IR and with metabolic risk factors like HDL-C. Larger sample sizes are needed to probe correlation with other metabolic risk factors in PCOS women. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review
European Journal of Endocrinology, 2013
ContextMetabolic disturbances, in particular, insulin resistance (IR) and dyslipidemia, are common in women suffering from polycystic ovary syndrome (PCOS). Evidence is accumulating that vitamin D status may contribute to the development of metabolic disturbances in PCOS.ObjectiveThe aim of this study was to carry out a systematic review addressing the association between vitamin D status, vitamin D receptor polymorphisms, and/or polymorphisms related to vitamin D metabolism and metabolic disturbances in women with PCOS.Design and methodsA systematic search of electronic databases was carried out up to January 2013 for observational studies and clinical trials in women suffering from PCOS with outcome measures that were related to vitamin D status. We conducted univariate and multivariate regression analyses of the weighted means to gain insights into the association between vitamin D, BMI, and IR based on existing literature.ResultsWe found 29 eligible trials with inconsistency in ...
Vitamin D predictors in polycystic ovary syndrome: a meta-analysis
European Journal of Clinical Investigation, 2017
Background: The aim of this meta-analysis was to examine differences and predictors of serum 25-hydroxyvitamin D concentrations in women with polycystic ovary syndrome (PCOS) compared with non-PCOS controls matched for body mass index. Materials and methods: Three databases were searched (2003-2015) to retrieve studies that evaluated serum 25-hydroxyvitamin D in PCOS women and controls. Meta-regression analysis was performed with anthropometric and metabolic/endocrine parameters as covariates. Results: Fourteen studies that included 2,262 women (1,150 PCOS patients/1,162 controls) were eligible. Serum 25-hydroxyvitamin D, follicle stimulating hormone and sex hormonebinding globulin were significantly lower in PCOS patients than controls. Homeostatic model assessment-insulin resistance index, serum insulin, total cholesterol, triglycerides, lowdensity lipoprotein cholesterol, luteinizing hormone and testosterone were significantly higher in PCOS patients compared to controls. Meta-regression analysis demonstrated significant effects of waist-to-hip ratio and glucose in PCOS women (β =-1.