Nigella Sativa and Ginger Increase GLUT4 and PPARγ in Metabolic Syndrome‐Induced Rats (original) (raw)
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Journal of Oleo Science, 2014
INTRODUCTION Metabolic syndrome MS is a combination of medical disorders linked to overweight, central obesity, insulin resistance, dyslipidemia and hypertension 1, 2. Patients suffering from MS have increased chance of having heart diseases, stroke and type 2 diabetes 3, 4. MS is diagnosed if a person have at least three of the following metabolic risk factors; large waistline, high blood pressure, high fasting blood sugar, high TG and low level of HDL-C 5, 6. It was estimated that prevalence of MS in the USA to be up to 25 of all US adults 7, 8. In Saudi Arabia, a study showed that the prevalence of MS is high accounting to 39.3 and that Saudi subjects from urban areas have significantly higher prevalence compared to those living in
Journal of Veterinary Medicine Series A, 2001
This study was carried out to investigate whether Nigella sativa could decrease the lipid peroxidation, increase the anti-oxidant defence system and also prevent the lipid-peroxidationinduced liver damage in experimentally induced diabetic rabbits. Fifteen New Zealand male rabbits were divided into three experimental groups: control, diabetic and diabetic and N. sativa-treated. The diabetes mellitus (DM) was induced in the rabbits using 150 mg/kg of 10% alloxan. The diabetic + N. sativa-treated group was given extract of N. sativa seeds orally every day for 2 months after induction of DM. At the end of the 2-month experiment, blood samples were collected to measure malondialdehyde (MDA), glutathione (GSH), ceruloplasmin and glucose concentration, and livers were harvested for histopathological analysis. Treatment with N. sativa decreased the elevated glucose and MDA concentrations, increased the lowered GSH and ceruloplasmin concentrations, and prevented lipid-peroxidation-induced liver damage in diabetic rabbits. It was concluded that N. sativa might be used in diabetic patients to prevent lipid peroxidation, increase anti-oxidant defence system activity and also prevent liver damage.
Biochemical effects of Nigella sativa L seeds in diabetic rats
Indian journal of …, 2006
Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptozotocin induced diabetic rats for 30 days significantly reduced the elevated levels of blood glucose, lipids, plasma insulin and improved altered levels of lipid peroxidation products (TBARS and hydroperoxides) and antioxidant enzymes like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase in liver and kidney. The results confirm the antidiabetic activity of N. sativa seeds extract and suggest that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic rats.
The objective of this study was to evaluate the possible antidiabetic and insulin tropic effect of nigella sativa seeds water extract and/or lipoic acid. For this purpose, Forty male Wistar strain albino rats were divided into five groups (8 rat /group), group 1; control group, group2; normal rats fed on basal diet and received 21% fructose in drinking water for four weeks then injected intraperitoneally by a single streptozotocin (STZ) dose (40 mg/kg) to induce type2 diabetes and served as diabetic control group , group3; diabetic rats orally administrated water extract of nigella sativa (1ml/kg daily for 6 weeks), group4; diabetic rats orally administrated lipoic acid (100 mg/kg daily for 6 weeks), group5;diabetic rats orally administrated aqueous extract of nigella sativa and lipoic acid daily simultaneously at the previous tested doses for 6 weeks. Untreated diabetic group showed a significant increase in serum glucose, total cholesterol, triacylglycerols, transforming growth factor beta (TGF- β)and leptin. Also, hepatic total lipids, total cholesterol, alcohol dehydrogenase (AD) activity were significantly elevated in untreated diabetic group as compared to normal control. Whereas, serum insulin, C-peptide, insulin like growth factor -1(IGF-1), hepatic glycogen and NADPH were significantly reduced in untreated diabetic group as compared to normal control. Moreover, the activities of hepatic enzymes cytochrome p450 reductase, glucose-6-phosphate dehydrogenase (G-6-P-D), Glyoxalase I and II were significantly reduced in untreated diabetic rat as compared to normal control group (p<0.05). Oral administration of nigella sativa seeds water extract and /or lipoic acid restored all these altered biochemical parameters to near normal levels. Conclusion the ameliorative effect of water extract of nigella sativa and /or lipoic acid on altered carbohydrate , lipid and oxidative stress variables in type 2 diabetic rats , may be attributed to their insulin releasing capacity, lipid lowering effect and antioxidative effect.
There is a large global trend toward the use of medicinal herbs for the treatment of diabetes, and many people employ complementary and alternative medicine. The objective of the study was to provide comprehensive information on the effects of Nigella sativa on lipid profile, glucose level, and body weight in diabetic-induced rats. This is a comprehensive review carried out through PubMed, Science Direct, Google scholar and Springer and other Scientific Electronic Library Online databases, using the keywords; "N. sativa", "black seed", "diabetes", "glucose", "lipid", "Weight", and "insulin" associated with the Boolean operator "AND". At first, 241 articles from 2000 to 2022 were discovered. Following the application of the specified inclusion and exclusion criteria, 21 papers were still available, and 15 underwent complete reading, after which all were included in the study. According to their findings, N. sativa has a variety of possible mechanisms for controlling hyperglycemia and abnormal lipid profiles, including its antioxidant properties and influences on insulin secretion, glucose absorption and body weight. However, further clinical studies are required to determine the N. sativa therapeutic benefits, as well as the kind and dose that work best for managing diabetes and its consequences.
Hypoglycemic Effects of Extract Nigella Sativa in Diabetic mice model
International Islamic Medical Journal, 2019
Background; Adiponectin is an important adipokine with anti-inflammatory and insulin-sensitizing effects, the circulating levels of which are reduced in individuals with type 2 diabetes and obesity. Indeed, there is evidence that adiponectin released from perivascular adipose tissue (PVAT), that may play a key role in vascular physiology, as bioactive molecules released from it could have direct paracrine effects on the underlying vessel. The present study investigated the effects of extract Nigella sativa (N. sativa) on blood glucose levels of diabetic mice. Materials; Eight-week-old male musmusculus were treated with alloxan (150 mg/ kg) by a single intraperitoneal injection to induce diabetes mellitus. At 3 days of injection, N. sativa extract (150 and 300 mg/kg) was administered via gavage for 2 weeks. Results: The extract of N.Sativa administration significantly reduced blood glucose level (P
Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats
Journal of Ethnopharmacology, 2009
Aim of the study: Nigella sativa L. (Ranunculaceae) seeds have been used traditionally for centuries, notably for treating diabetes. Materials and methods: We studied the effects of the crude aqueous extract of Nigella sativa seeds on intestinal glucose absorption in vitro using a short-circuit current technique and in vivo using an oral glucose tolerance test. Results: The aqueous extract of Nigella sativa (0.1 pg/ml to 100 ng/ml) exerted dose-dependent inhibition of sodium-dependent glucose transport across isolated rat jejunum. Maximal inhibition exceeded 80% and IC 50 was close to 10 pg/ml. An oral glucose tolerance test was carried out in rats after the initial dose and after a 6-week treatment of Nigella sativa (2 g/(kg day)), and compared to metformin (300 mg/(kg day)). Chronic Nigella sativa treatment improved glucose tolerance as efficiently as metformin. Nigella sativa and metformin also reduced body weight without any toxic effect. Conclusions: To our knowledge, this is the first demonstration that Nigella sativa directly inhibits the electrogenic intestinal absorption of glucose in vitro. Together with the observed improvement of glucose tolerance and body weight in rats after chronic oral administration in vivo, these effects further validate the traditional use of Nigella sativa seeds against diabetes.
Evidence-Based Complementary and Alternative Medicine, 2014
In the recent era, diabetes mellitus has emerged as one of the significant threats to public health and this situation demands the attention of the researchers and allied stakeholders. Dietary regimens using functional and nutraceutical foods are gaining wide range of acceptance and some traditional medicinal plants are of considerable importance. The main objective of this instant study was to explore the antidiabetic potential of Nigella sativa fixed oil (NSFO) and essential oil (NSEO). Three experimental groups of rats received diets during the entire study duration, that is, D 1 (control), D 2 (NSFO: 4.0%), and D 3 (NSEO: 0.30%). Experimental diets (NSFO & NSEO) modulated the lipid profile, while decreasing the antioxidant damage. However, production of free radicals, that is, MDA, and conjugated dienes increased by 59.00 and 33.63%, respectively, in control. On the contrary, NSFO and NSEO reduced the MDA levels by 11.54 and 26.86% and the conjugated dienes levels by 32.53 and 38.39%, respectively. N. sativa oils improved the health and showed some promising anti-diabetic results.