Non Syndromic Multiple Keratocystic Odontogenic Tumors in a Patient in His Late 50’S: A Case Report (original) (raw)

Non-Syndromic Multiple Keratocystic Odontogenic Tumor: A Rare Case Report and Review of Literature

KeratocysticOdontogenic tumor (KCOT) has been the topic of various researchers and is distinctive for its potentially aggressive behavior and tendency for multiplicity. It is anodontogenic tumorthat exhibits a hyperkeratinizedepithelial lining. The lesion originates from the cell-rests of the dental lamina rather than from the reduced enamel epithelium or the cell rests of Malassez. It constitutes for 3.11% of all odontogenic cysts. It often occurs as a solitary lesion at the angle of mandible and multiple lesions may occur in association with systemic changes. Here is a rare case report ofmultiple KCOTsassociated with an ovarian cyst in 30 years old female.

AC omparative Study of Sporadic and Multiple Keratocystic Odontogenic Tumor : a Review of 196 Tumors

2008

F rom the files of the Division of Pathology, Department of Diagnosis & Therapeutic Sciences, Meikai Uni- versity School of Dentistry, 196 tumors diagnosed as keratocystic odontogenic tumor (KCOT) based on the guidelines of the 2005 classification of the World Health Organization (WHO) were studied. The features of 152 sporadic KCOTs were compared with those of 44 multiple KCOTs. The age and sex of the patients, the site of occurrence, and the association with nevoid basal cell carcinoma syndrome were taken in consideration. The mean age of patients with multiple KCOTs was lower (22.9 years) than that of patients with sporadic KCOTs (35.6 years). The peak incidence of the tumors was in the third and second decades of life for single and multiple KCOTs respectively. There were no significant histological differ- ences between the two groups except for a greater amount of daughter cysts and a tendency for multiple recurrence in the multiple KCOT group. The term multiple KCOT refers to...

Case report: multiple keratocystic odontogenic tumour in a non-syndromal pediatric patient

European Archives of Paediatric Dentistry. Official Journal of the European Academy of Paediatric Dentistry.

Keratocystic odontogenic tumour (KCOT) is an odontogenic tumour which stems from the odontogenic organs mostly localised in the lower jaw, particularly posterior body and ascending ramus of the mandible. The majority of these tumours are single lesions. When detected in the jaw in multiple forms, these cysts are seen in association with Gorlin Goltz/Basal cell naevus syndrome. However a few cases of non-syndromal multiple keratocystic odontogenic tumour have been reported in the literature.

Multiple keratocystic odontogenic tumors in a non-syndromic minor patient: Report of an unusual case

Journal of Orofacial Sciences, 2013

Keratocystic odontogenic tumor (KCOT) is developmental odontogenic cysts of epithelial origin known for their potentially aggressive behavior and significant rate of recurrences. Single odontogenic cysts are very well documented in the literature. Multiple (KCOT) are principle features of nevoid basal cell carcinoma syndrome (naevoid basal cell carcinoma syndrome; Gorlin-Goltz syndrome). We report an intriguing case of multiple KCOT in a non-syndromic patient simultaneously occurring in maxilla as well as in mandible with brief highlight on molecular data and the treatment modality.

Presentation of a keratocystic odontogenic tumor with agenesis: a case report

Journal of Medical Case Reports, 2014

Introduction: We analyzed the etiopathogenetic, clinical, radiographic, and histopathologic aspects of keratocystic odontogenic tumors, particularly in association with dental anomalies of number, with the aim of providing useful information for their correct diagnosis, treatment, and prognosis within a multidisciplinary approach. Case presentation: A 14-year-old Caucasian girl presented for observation of bilateral agenesis of the upper incisors, which was diagnosed by orthopantomography. Approximately one year after starting orthodontic treatment, the patient went to the emergency department because of a phlegmonous tumefaction of the lateroposterior upper left maxillary region. Diagnostic orthopantomography and axial computed tomography scan results of the facial skeleton revealed a large lesion occupying the left maxillary sinus, rhizolysis of dental elements 26 and 27, and dislocation of dental element 28. The lesion and infected sinus mucosa were removed through surgical antral-cystectomy with the Caldwell-Luc approach. Histological examination of the lesion confirmed the suspected diagnosis of keratocystic odontogenic tumor. The 12-month follow-up orthopantomography and computed tomography scan results showed good trabecular bone formation in the lesion area. The 24-month follow-up results showed optimal healing in the area of the lesion, positive pulp vitality tests for teeth 26 and 27, and good periodontal tissue healing, as verified through periodontal probing. Conclusions: Combined with our observations from a careful review of the literature, the results of the case study suggest that keratocystic odontogenic tumor and dental agenesis probably do not develop through a common genetic cause. More likely, they are caused by related environmental factors. Management of this case required the multidisciplinary collaboration of different specializations and careful planning to devise a correct therapeutic protocol and reach a favorable prognosis.

Keratocystic odontogenic tumor: a retrospective study of 183 cases

Journal of Oral Science, 2008

In 2005, the WHO Working Group considered odontogenic keratocyst (OKC) to be a tumor and recommended the term keratocystic odontogenic tumor (KCOT), separating the lesion from the orthokeratinizing variant, which is now considered an odontogenic cyst. We analyzed the clinicopathological features of KCOTs encountered over a period of 28 years at Meikai University Hospital. The diagnosis was confirmed by reevaluation of hematoxylin and eosin-stained slides on the basis of the 2005 WHO Classification. Clinical history was also taken into consideration. A total of 183 KCOTs were found, and the two genders were affected almost evenly (51.3% male; 48.7% female; male to female ratio 1.05 to 1). Patient age at the time of diagnosis ranged from 6 to 78 years, with a peak in the third decade of life (mean age: 32.8 years). The mandible was the site of occurrence of 70.5% of tumors; 16.4% occurred in the maxilla and 13.1% in both. Association with the nevoid basal cell carcinoma syndrome (NBCCS) was found in 6.0% of all tumors, and recurrence was found in 13.1% of patients. We found that tumors that initially appeared in the maxilla alone had a higher recurrence rate than those that first appeared in the mandible alone. Pathological examination of KCOT is important to avoid misdiagnosis and provide appropriate treatment and follow-up.

Keratocystic Odontogenic Tumor: A Case Report And Review Of The Literature

The Internet Journal of Dental Science, 2009

Because of its agressvity, its high recurrence and possible malignant transformation, odontogenic keratocyst is added to the benign odontogenic tumours category, the new term is keratocystic odontogenic tumor (KCOT). its pathogenesis and its treatment were largely studied in the latest years in order to improve its prognosis. we present a case of 80 year old patient who presents KCOT occurring in chin area, the selected treatment was the enucleation of the lesion. We present also a literature review, while insisting especially on the pathogenesis and the treatment of the KCOT.

Keratocystic odontogenic tumor. Case report and review of the literature

The New York state dental journal, 2013

Keratocystic odontogenic tumor is an intraosseous benign tumor of epithelial origin that can appear as a unicystic or multicystic lesion. It is characterized most significantly by its high recurrence rate. This is why surgical removal is the chosen therapeutic approach in most cases. However, while surgery may be the safest technique to prevent recidivism, it may also result in numerous complications with large tumors. A number of authors have suggested a more conservative treatment for large keratocystic odontogenic tumors. The case examined in this article is that of a 48-year-old male patient who presented with a five-month swelling on the left side of his face, located in the mandibular area.

Odontogenic Keratocyst Tumor: A Case Report and Literature Review

Open Journal of Stomatology, 2016

First described by Philipsen in 1956, the odontogenic keratocyst is characterized by a large squamous keratinization of its border, an aggressive growth and a high recurrent rate. It is now designated by the World Health Organization as a keratocystic odontogenic tumour (KOT). Clinically, the KOT is manifested by an asymptomatic growth. Radiographically, it appears as a well-defined unilocular or multilocular osteolytic lesion. The diagnostic approach is based on a combined analysis of the medical history, the clinical appearance and the radiographic appearance. The diagnosis may be confirmed by the anatomical pathology report. Finally, treatment consists of surgical excision and follow up is characterized by a high rate of recurrence. The authors report a case of keratocystic odontogenic tumor of the upper jaw and review the various diagnoses, therapeutics and follow up aspects of this type of tumors.