Bone Regenerations Research Papers - Academia.edu (original) (raw)

Following tooth extraction, a socket often presents dimensions that may be considerably greater that the diameter of a conventional implant. The present experiment was performed to study the healing that occurred adjacent to implants placed in recipient sites with a wide marginal defect. Four Labrador dogs were used. In the right side of the mandible, four experimental sites were prepared to receive titanium implants [sandblasted, large-grit, acid-etched (SLA) surface]. Traditional implant installation (control) was performed in one site. In the remaining three sites (test), a step drill was used to widen the marginal 5 mm of the canal. Following placement of an implant in a test site, a circumferential gap about 1–1.25 mm wide and 5 mm deep was present lateral to the implant. A resorbable barrier membrane was used to cover the implant and the bone tissue of two sites, while one site was left uncovered. Four months following implant installation, block biopsies of each implant site were obtained and prepared for ground sectioning. After 4 months of healing, the large marginal defect had been filled with newly formed bone. The degree of bone-to-implant contact between the newly formed tissue and the SLA surface was at all test sites high and similar to that obtained at control sites. The placement of a barrier membrane following implant installation did not improve the outcome of healing. We conclude that a marginal defect wider than 1 mm may heal with new bone and a high degree of osseointegration to an implant designed with a SLA surface.

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- Dental Implant, Bone Regenerations, marginal defect at implants

RESUMEN Los tratamientos de implantes dentales se han convertido en un tratamiento cotidiano dentro de la práctica diaria, por lo que la presencia de defectos del reborde alveolar que se da por la reabsorción ósea ha conllevado al desarrollo de muchos procedimientos de aumento óseo con la intención de mejorar la cantidad y calidad del hueso, para así lograr un tratamiento de implantes dentales predecible. El objetivo de esta revisión de la literatura es la de presentar los principales procedimientos referidos al manejo de los defectos horizontales del reborde alveolar, que siempre representan un desafío para los clínicos. ABSTRACT Dental implant treatments have become a daily treatment within daily practice, so that the presence of defects of the alveolar ridge that results from bone resorption has led to the development of many bone augmentation procedures with the intention of improving the quantity and quality of the bone to achieve a predictable dental implant treatment. The objective of this review of the literature is to present the main procedures related to the management of horizontal defects of the alveolar ridge, which are always a challenge for clinicians.

- by Britto Falcon
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- Periodontics, Implantology, Dental Research, Regeneration
- by Abdulaziz Al Kheraif
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- Seaweeds, Periodontal Tissue Regeneration, Food Sciences, Bone Regenerations

Over the past two decades numerous studies have been reported on seaweeds-derived polysaccharides for biomedical and biological applications (tissue engineering, drug delivery, wound healing, and biosensor). Alginate, carrageenan, fucoidan, and ulvan are widely used marine derived polysaccharides for biological and biomedical applications due to their biocompatibility and availability. The gel forming property of alginate has increased its applications in tissue engineering and drug delivery as an extracellular matrix and delivery vehicle, respectively. Other sulfated polysaccharides such as carrageenan and fucoidan show promising application in tissue engineering due to their capacity of inducing important osteogenic, adipogenic, and chondrogenic differentiation in stem cells. In this review, we explained the extraction/isolation methods and applications of these seaweed derived polysaccharides as well as their roles in therapeutics, drug delivery, and tissue engineering.

- by Anil Sukumaran and +1
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- Seaweeds, Periodontal Tissue Regeneration, Bone Regenerations

Fabrication of an ideal scaffold having proper composition, physical structure and able to have sustained release of growth factors still is challenging for bone tissue engineering. Current study aimed to design an appropriate three-dimensional (3-D) scaffold with suitable physical characteristics, including proper compressive strength, degradation rate, porosity, and able to sustained release of bone morphogenetic protein-2 (BMP2), for bone tissue engineering. A highly porous 3-D β-tricalcium phosphate (β-TCP) scaffolds, inside of which two perpendicular canals were created, was fabricated using foam-casting technique. Then, scaffolds were coated with gelatin layer. Next, BMP2-loaded chitosan (CS) nanoparticles were dispersed into collagen hydrogel and filled into the scaffold canals. Physical characteristics of fabricated constructs were evaluated. Moreover, the capability of given construct for bone regeneration has been evaluated in vitro in interaction with human buccal fat pad-derived stem cells (hBFPSCs). The results showed that gelatin-coated TCP scaffold with rhBMP2 delivery system not only could act as a mechanically and biologically compatible framework, but also act as an osteoinductive graft by sustained delivering of rhBMP2 in a therapeutic window for differentiation of hBFPSCs towards the osteoblast lineage. The proposed scaffold model can be suggested for delivering of cells and other growth factors such as vascular endothelial growth factor (VEGF), alone or in combination, for future investigations.

- by Farshid Bastami
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- Biomaterials Engineering, Biomaterials, Tissue Engineering, Stem Cells

- by majid salehi
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- Biomaterials Engineering, Biomedical Engineering, Biomaterials, Bone Regeneration