Cholestatic jaundice Research Papers - Academia.edu (original) (raw)
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There are variety serious diseases of the children liver. Biliary atresia is the most frequent surgical cause of cholestatic jaundice in neonates and should be evoked whenever this clinical sign is associated with pale stools and... more
There are variety serious diseases of the children liver. Biliary atresia is the most frequent surgical cause of cholestatic jaundice in neonates and should be evoked whenever this clinical sign is associated with pale stools and hepatomegaly. Early diagnosis is the greatest help for these children. Without surgical treatment these patients die during the first two years of life from the progression of the liver disease, oesophageal bleeding or infection. In this article we would like to provide a brief overview of these diseases, describe the main diagnostic criteria, and we also want to turn the attention of pediatricians and neonatologists on diagnostic difficulties during the diagnostic period. Despite of the rarity of these diseases, biliary atresia should be on the list of differential diagnoses. Thanks to early diagnosis, performance of Kasai portoenterostomy and the possibility of liver transplantation was made significant progress in the treatment of children with those diseases in the last decade.