PET Radiochemistry Research Papers - Academia.edu (original) (raw)
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Carbon-11 labeled acetone is a useful radiosynthetic precursor. Previously, strict control of no-carrier-added stoichiometry was required to prepare it from reaction of CO2 and methyl lithium. However, excess methyl lithium may be... more
Carbon-11 labeled acetone is a useful radiosynthetic precursor. Previously, strict control of
no-carrier-added stoichiometry was required to prepare it from reaction of CO2 and methyl lithium. However,
excess methyl lithium may be selectively quenched to avoid reaction with nascent acetone to give tert-butanol.
We report a simple pKa-based strategy to sequentially and selectively quench MeLi and acetone to give yields
of up to 100% acetone even in the presence of a large excess of MeLi. The method gives good yields of acetone
under conditions that previously precluded its synthesis.