Progress and problems with the use of viral vectors for gene therapy - PubMed (original) (raw)

Review

doi: 10.1038/nrg1066.

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• PMID: 12728277
• DOI: 10.1038/nrg1066

Review

Progress and problems with the use of viral vectors for gene therapy

Clare E Thomas et al. Nat Rev Genet. 2003 May.

Abstract

Gene therapy has a history of controversy. Encouraging results are starting to emerge from the clinic, but questions are still being asked about the safety of this new molecular medicine. With the development of a leukaemia-like syndrome in two of the small number of patients that have been cured of a disease by gene therapy, it is timely to contemplate how far this technology has come, and how far it still has to go.

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