Association of matrix metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis - PubMed (original) (raw)
Association of matrix metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis
H H Lee et al. Parasitol Res. 2004 Nov.
Abstract
Induction of gelatinase in eosinophilic meningitis of BALB/c-strain mice was caused by Angiostrongylus cantonensis. Time-course studies showed that the molecular weight of 94-kDa gelatinase was detected at day 10 post-inoculation (PI), and reached a high intensity from days 15 to 25 PI. The 94-kDa gelatinase activity was clearly inhibited by EDTA and 1,10-phenanthroline, but not by leupeptin and phenylmethanesulphonyl fluoride. When immunoblots were performed using specific antiserums against the 94-kDa gelatinase B (matrix metalloproteinase-9; MMP-9) with cerebrospinal fluid (CSF), the 94-kDa immunopositive band was MMP-9. Immunohistochemistry studies demonstrated MMP-9 localisation within eosinophils and macrophages. The increased MMP-9 activity was closely associated with the rapid rise of CSF eosinophils, and the inflammatory reaction of the subarachnoid space. In contrast to changes in MMP-9, MMP-2 activity was constitutive and unaffected in this parasitic meningitis. These results show that MMP-9 was associated with eosinophilic meningitis, and that the enzyme may be a useful marker for angiostrongyliasis meningitis.
Similar articles
- Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused by Angiostrongylus cantonensis.
Lai SC, Twu JJ, Jiang ST, Hsu JD, Chen KM, Chiaing HC, Wang CJ, Tseng CK, Shyu LY, Lee HH. Lai SC, et al. Ann Trop Med Parasitol. 2004 Oct;98(7):715-24. doi: 10.1179/000349804225021479. Ann Trop Med Parasitol. 2004. PMID: 15509425 - Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis.
Chen KM, Lee HH, Chou HL, Liu JY, Tsai BC, Lai SC. Chen KM, et al. Int J Exp Pathol. 2005 Apr;86(2):81-9. doi: 10.1111/j.0959-9673.2005.00413.x. Int J Exp Pathol. 2005. PMID: 15810979 Free PMC article. - Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Wei PC, Tsai CH, Chiu PS, Lai SC. Wei PC, et al. Int J Parasitol. 2011 Sep;41(11):1175-83. doi: 10.1016/j.ijpara.2011.07.002. Epub 2011 Aug 6. Int J Parasitol. 2011. PMID: 21856305 - Drug target in eosinophilic meningitis caused by Angiostrongylus cantonensis.
Sawanyawisuth K, Sawanyawisuth K. Sawanyawisuth K, et al. Infect Disord Drug Targets. 2010 Oct;10(5):322-8. doi: 10.2174/187152610793180867. Infect Disord Drug Targets. 2010. PMID: 20701570 Review. - Meningitis and radiculomyelitis caused by Angiostrongylus cantonensis.
Maretić T, Perović M, Vince A, Lukas D, Dekumyoy P, Begovac J. Maretić T, et al. Emerg Infect Dis. 2009 Jun;15(6):996-8. doi: 10.3201/eid1506.081263. Emerg Infect Dis. 2009. PMID: 19523323 Free PMC article. Review. No abstract available.
Cited by
- Angiostrongylus cantonensis infection induces MMP-9 and causes tight junction protein disruption associated with Purkinje cell degeneration.
Lai SC, Lu CY, Shyu LY, Chen KM. Lai SC, et al. Parasitol Res. 2020 Oct;119(10):3433-3441. doi: 10.1007/s00436-020-06840-y. Epub 2020 Aug 13. Parasitol Res. 2020. PMID: 32789733 - Excretory/secretory products of Angiostrongylus cantonensis fifth-stage larvae induce endoplasmic reticulum stress via the Sonic hedgehog pathway in mouse astrocytes.
Chen KY, Chen YJ, Cheng CJ, Jhan KY, Wang LC. Chen KY, et al. Parasit Vectors. 2020 Jun 18;13(1):317. doi: 10.1186/s13071-020-04189-w. Parasit Vectors. 2020. PMID: 32552877 Free PMC article. - Proteasome serves as pivotal regulator in Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis.
Chen AC, Shyu LY, Lin YC, Chen KM, Lai SC. Chen AC, et al. PLoS One. 2019 Aug 15;14(8):e0220503. doi: 10.1371/journal.pone.0220503. eCollection 2019. PLoS One. 2019. PMID: 31415587 Free PMC article. - The significance of matrix metalloproteinases in parasitic infections involving the central nervous system.
Bruschi F, Pinto B. Bruschi F, et al. Pathogens. 2013 Feb 19;2(1):105-29. doi: 10.3390/pathogens2010105. Pathogens. 2013. PMID: 25436884 Free PMC article. Review. - Gene expression profile of LPS-stimulated dendritic cells induced by a recombinant Sj16 (rSj16) derived from Schistosoma japonicum.
Shen J, Xu L, Liu Z, Li N, Wang L, Lv Z, Fung M, Wu Z, Sun X. Shen J, et al. Parasitol Res. 2014 Aug;113(8):3073-83. doi: 10.1007/s00436-014-3973-y. Epub 2014 Jun 7. Parasitol Res. 2014. PMID: 24906993
References
- Infect Immun. 2000 Feb;68(2):615-20 - PubMed
- West J Med. 1993 Nov;159(5):623 - PubMed
- Crit Rev Oral Biol Med. 1993;4(2):197-250 - PubMed
- Eur J Biochem. 1991 Jun 1;198(2):391-8 - PubMed
- J Biol Chem. 1986 Feb 25;261(6):2810-3 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous