Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection - PubMed (original) (raw)

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

Lishomwa C Ndhlovu et al. AIDS. 2008.

Abstract

IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

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Figures

Fig. 1. Detection and comparison of the frequencies of IL-17 and IFN-γ secreting cells in peripheral blood mononuclear cells (PBMCs) derived from HIV-1-infected and uninfected subjects

Graphs depict the frequency of (a) IL-17 and (b) IFN-γ secreting PMBCs in spot forming units (SFU)/106 PBMCs from HIV-1-uninfected adults, unexposed uninfected children, exposed but uninfected controls and infected pediatric subjects in response to anti-CD3/anti-CD28 stimulation. HIV-1-infected pediatric subjects were segregated depending on the level of viremia to more than 50 copies/ml or less than 50 copies/ml. The **_P_-value was derived from the Mann–Whitney test and considered statistically significant if the value was less than 0.05. (c) The degree of correlation was assessed by using Spearman's rank correlation coefficient for nonparametric data between HIV-1 plasma viremia and the frequency of IL-17 SFU. EU, exposed uninfected; UU, unexposed uninfected.

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Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection - PubMed (original) (raw)