Omega-3 polyunsaturated fatty acids and cardiovascular diseases - PubMed (original) (raw)
Review
. 2009 Aug 11;54(7):585-94.
doi: 10.1016/j.jacc.2009.02.084.
Affiliations
- PMID: 19660687
- DOI: 10.1016/j.jacc.2009.02.084
Free article
Review
Omega-3 polyunsaturated fatty acids and cardiovascular diseases
Carl J Lavie et al. J Am Coll Cardiol. 2009.
Free article
Abstract
Omega-3 polyunsaturated fatty acid (omega-3 PUFA) therapy continues to show great promise in primary and, particularly in secondary prevention of cardiovascular (CV) diseases. The most compelling evidence for CV benefits of omega-3 PUFA comes from 4 controlled trials of nearly 40,000 participants randomized to receive eicosapentaenoic acid (EPA) with or without docosahexaenoic acid (DHA) in studies of patients in primary prevention, after myocardial infarction, and most recently, with heart failure (HF). We discuss the evidence from retrospective epidemiologic studies and from large randomized controlled trials showing the benefits of omega-3 PUFA, specifically EPA and DHA, in primary and secondary CV prevention and provide insight into potential mechanisms of these observed benefits. The target EPA + DHA consumption should be at least 500 mg/day for individuals without underlying overt CV disease and at least 800 to 1,000 mg/day for individuals with known coronary heart disease and HF. Further studies are needed to determine optimal dosing and the relative ratio of DHA and EPA omega-3 PUFA that provides maximal cardioprotection in those at risk of CV disease as well in the treatment of atherosclerotic, arrhythmic, and primary myocardial disorders.
Comment in
- The role of omega-3 fatty acids in primary prevention of coronary artery disease and in atrial fibrillation is controversial.
Saravanan P, Davidson NC. Saravanan P, et al. J Am Coll Cardiol. 2010 Jan 26;55(4):410-1; author reply 411-2. doi: 10.1016/j.jacc.2009.09.032. J Am Coll Cardiol. 2010. PMID: 20117448 No abstract available.
Similar articles
- n-3 PUFAs and cardiovascular disease prevention.
Manerba A, Vizzardi E, Metra M, Dei Cas L. Manerba A, et al. Future Cardiol. 2010 May;6(3):343-50. doi: 10.2217/fca.10.19. Future Cardiol. 2010. PMID: 20462340 Review. - Omacor (prescription omega-3-acid ethyl esters 90): From severe rhythm disorders to hypertriglyceridemia.
Rupp H. Rupp H. Adv Ther. 2009 Jul;26(7):675-90. doi: 10.1007/s12325-009-0045-2. Epub 2009 Jul 27. Adv Ther. 2009. PMID: 19629408 Review. - Cardiovascular disease prevention and treatment.
von Schacky C. von Schacky C. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):193-8. doi: 10.1016/j.plefa.2009.05.009. Epub 2009 Jun 10. Prostaglandins Leukot Essent Fatty Acids. 2009. PMID: 19520557 Review. - Docosahexaenoic acid (DHA) and cardiovascular disease risk factors.
Holub BJ. Holub BJ. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):199-204. doi: 10.1016/j.plefa.2009.05.016. Epub 2009 Jul 9. Prostaglandins Leukot Essent Fatty Acids. 2009. PMID: 19545988 Review. - Fatty acid facts, Part III: Cardiovascular disease, or, a fish diet is not fishy.
Pauwels EK, Kostkiewicz M. Pauwels EK, et al. Drug News Perspect. 2008 Dec;21(10):552-61. doi: 10.1358/dnp.2008.21.10.1314058. Drug News Perspect. 2008. PMID: 19221636 Review.
Cited by
- Blue Food Consumption and Its Relation to Nutrient Intake among Koreans.
Suk Y, Lee MJ, Ham S. Suk Y, et al. Nutrients. 2024 Sep 16;16(18):3128. doi: 10.3390/nu16183128. Nutrients. 2024. PMID: 39339728 Free PMC article. - Management of Coronary Vulnerable Plaque With Medical Therapy or Local Preventive Percutaneous Coronary Intervention.
Kim H, Ahn JM, Kang DY, Lee J, Choi Y, Park SJ, Park DW. Kim H, et al. JACC Asia. 2024 May 28;4(6):425-443. doi: 10.1016/j.jacasi.2024.04.001. eCollection 2024 Jun. JACC Asia. 2024. PMID: 39100699 Free PMC article. Review. - Omega-3 Polyunsaturated Fatty Acids Supplements and Cardiovascular Disease Outcome: A Systematic Review and Meta-Analysis on Randomized Controlled Trials.
Qi X, Zhu H, Ya R, Huang H. Qi X, et al. Rev Cardiovasc Med. 2023 Jan 12;24(1):24. doi: 10.31083/j.rcm2401024. eCollection 2023 Jan. Rev Cardiovasc Med. 2023. PMID: 39076869 Free PMC article. - The Role of Omega- 3 Polyunsaturated Fatty Acids in Diabetes Mellitus Management: A Narrative Review.
Bayram SŞ, Kızıltan G. Bayram SŞ, et al. Curr Nutr Rep. 2024 Sep;13(3):527-551. doi: 10.1007/s13668-024-00561-9. Epub 2024 Jul 20. Curr Nutr Rep. 2024. PMID: 39031306 Free PMC article. Review. - Fish oil supplementation modifies the associations between genetically predicted and observed concentrations of blood lipids: a cross-sectional gene-diet interaction study in UK Biobank.
Sun Y, McDonald T, Baur A, Xu H, Bateman NB, Shen Y, Li C, Ye K. Sun Y, et al. Am J Clin Nutr. 2024 Sep;120(3):540-549. doi: 10.1016/j.ajcnut.2024.07.009. Epub 2024 Jul 15. Am J Clin Nutr. 2024. PMID: 39019260 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous