Coexistence of peptides with classical neurotransmitters - PubMed (original) (raw)

Review

. 1987 Jul 15;43(7):768-80.

doi: 10.1007/BF01945354.

Review

Coexistence of peptides with classical neurotransmitters

T Hökfelt et al. Experientia. 1987.

Abstract

In the present article the fact is emphasized that neuropeptides often are located in the same neurons as classical transmitters such as acetylcholine, 5-hydroxy-tryptamine, catecholamines, gamma-aminobutyric acid (GABA) etc. This raises the possibility that neurons produce, store and release more than one messenger molecule. The exact functional role of such coexisting peptides is often difficult to evaluate, especially in the central nervous system. In the periphery some studies indicate apparently meaningful interactions of different types with the classical transmitter, but other types of actions including trophic effects have been observed. More recently it has been shown that some neurons contain more than one classical transmitter, e.g. 5-HT plus GABA, further underlining the view that transfer of information across synapses may be more complex than perhaps hitherto assumed.

PubMed Disclaimer

References

    1. Gen Cytochem Methods. 1958;1:399-422 - PubMed
    1. Acta Neuropathol. 1971;5:Suppl 5:226-37 - PubMed
    1. Cell Tissue Res. 1983;233(1):23-33 - PubMed
    1. Acta Physiol Scand. 1982 Dec;116(4):393-402 - PubMed
    1. Neurosci Lett. 1986 Aug 4;68(3):305-10 - PubMed

Publication types

MeSH terms

Substances