Association of immune cell subsets with incident heart failure in two population-based cohorts - PubMed (original) (raw)

Meta-Analysis

. 2022 Dec;9(6):4177-4188.

doi: 10.1002/ehf2.14140. Epub 2022 Sep 12.

Colleen M Sitlani 3, Margaret F Doyle 4, Alison E Fohner 5, Petra Buzkova 6, James S Floyd 3 5, Sally A Huber 4, Nels C Olson 4, Joyce N Njoroge 7, Jorge R Kizer 8, Joseph A Delaney 5 9, Sanjiv S Shah 1, Russell P Tracy 4 10, Bruce Psaty 3 5 11, Matthew Feinstein 1 2

Affiliations

Meta-Analysis

Association of immune cell subsets with incident heart failure in two population-based cohorts

Arjun Sinha et al. ESC Heart Fail. 2022 Dec.

Abstract

Aims: Circulating inflammatory markers are associated with incident heart failure (HF), but prospective data on associations of immune cell subsets with incident HF are lacking. We determined the associations of immune cell subsets with incident HF as well as HF subtypes [with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF)].

Methods and results: Peripheral blood immune cell subsets were measured in adults from the Multi-Ethnic Study of Atherosclerosis (MESA) and Cardiovascular Health Study (CHS). Cox proportional hazard models adjusted for demographics, HF risk factors, and cytomegalovirus serostatus were used to evaluate the association of the immune cell subsets with incident HF. The average age of the MESA cohort at the time of immune cell measurements was 63.0 ± 10.4 years with 51% women, and in the CHS cohort, it was 79.6 ± 4.4 years with 62% women. In the meta-analysis of CHS and MESA, a higher proportion of CD4+ T helper (Th) 1 cells (per one standard deviation) was associated with a lower risk of incident HF [hazard ratio (HR) 0.91, (95% CI 0.83-0.99), P = 0.03]. Specifically, higher proportion of CD4+ Th1 cells was significantly associated with a lower risk of HFrEF [HR 0.73, (95% CI 0.62-0.85), <0.001] after correction for multiple testing. No association was observed with HFpEF. No other cell subsets were associated with incident HF.

Conclusions: We observed that higher proportions of CD4+ Th1 cells were associated with a lower risk of incident HFrEF in two distinct population-based cohorts, with similar effect sizes in both cohorts demonstrating replicability. Although unexpected, the consistency of this finding across cohorts merits further investigation.

Keywords: Adaptive immunity; Heart failure; Innate immunity.

© 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

PubMed Disclaimer

Conflict of interest statement

Dr Shah has received research grants from Actelion, AstraZeneca, Corvia, Novartis, and Pfizer and has received consulting fees from Abbott, Actelion, AstraZeneca, Amgen, Axon Therapeutics, Bayer, Boehringer Ingelheim, Bristol‐Myers Squibb, Cardiora, CVRx, Cytokinetics, Eisai, GSK, Ionis, Ironwood, Lilly, Merck, MyoKardia, Novartis, Novo Nordisk, Pfizer, Regeneron, Sanofi, Shifamed, Tenax, and United Therapeutics. Dr Psaty serves on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. JSF has consulted for Shionogi Inc. The remaining authors have no disclosures to report.

Figures

Figure 1

Figure 1

Association of pre‐specified immune cells with incident heart failure.

References

    1. Vasan RS, Sullivan LM, Roubenoff R, Dinarello CA, Harris T, Benjamin EJ, Sawyer DB, Levy D, Wilson PW, D'Agostino RB, Framingham Heart Study . Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: The Framingham heart study. Circulation. 2003; 107: 1486–1491. -PubMed
    1. Ohkuma T, Jun M, Woodward M, Zoungas S, Cooper ME, Grobbee DE, Hamet P, Mancia G, Williams B, Welsh P, Sattar N, Shaw JE, Rahimi K, Chalmers J, ADVANCE Collaborative Group . Cardiac stress and inflammatory markers as predictors of heart failure in patients with type 2 diabetes: The ADVANCE trial. Diabetes Care. 2017; 40: 1203–1209. -PMC -PubMed
    1. Kalogeropoulos A, Georgiopoulou V, Psaty BM, Rodondi N, Smith AL, Harrison DG, Liu Y, Hoffmann U, Bauer DC, Newman AB, Kritchevsky SB, Harris TB, Butler J, Health ABC Study Investigators . Inflammatory markers and incident heart failure risk in older adults: The health ABC (health, aging, and body composition) study. J Am Coll Cardiol. 2010; 55: 2129–2137. -PMC -PubMed
    1. Levine B, Kalman J, Mayer L, Fillit HM, Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med. 1990; 323: 236–241. -PubMed
    1. Hage C, Michaëlsson E, Linde C, Donal E, Daubert JC, Gan LM, Lund LH. Inflammatory biomarkers predict heart failure severity and prognosis in patients with heart failure with preserved ejection fraction: A holistic proteomic approach. Circ Cardiovasc Genet. 2017; 10: e001633. -PubMed

Publication types

MeSH terms

Grants and funding

LinkOut - more resources