Coagulopathy correlates with muscle titin injury in critically ill patients - PubMed (original) (raw)

Observational Study

doi: 10.1016/j.jcrc.2022.154234. Epub 2022 Dec 22.

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Observational Study

Coagulopathy correlates with muscle titin injury in critically ill patients

Kensuke Nakamura et al. J Crit Care. 2023 Apr.

Abstract

Purpose: We hypothesized that coagulopathy independently contributes to muscle injury focusing to titin fragmentation, and investigated their correlations.

Material and methods: We conducted a post-hoc analysis of an observational study, in which we evaluated muscle injury with the biomarker titin. Coagulopathy was assessed on the first day using the Japanese diagnostic criteria of acute-phase disseminated intravascular coagulopathy (JAAM-DIC). Mean N-titin/Cre measured on days 1, 3, 5, and 7 was assigned as the primary outcome.

Results: Overall, 111 eligible patients were included. Mean N-titin/Cre were significantly higher in the JAAM-DIC group. A multivariable analysis identified JAAM-DIC as independent risk factors for mean N-titin/Cre while other severity scores were not.

Conclusions: Coagulopathy correlated with muscle titin fragmentation, as an independent risk factor.

Trial registration number: The present study is registered at the University Hospital Medical Information Network-clinical trials registry (UMIN000040290, Registration date: May 7, 2020).

Keywords: Coagulopathy; DIC; ICU-AW; Muscle; Myopathy.

Copyright © 2022 Elsevier Inc. All rights reserved.

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Conflict of interest statement

Declaration of Competing Interest The authors declare no competing interests related to this manuscript.

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