ABL1とは - わかりやすく解説 Weblio辞書 (original) (raw)

ABL1
PDBに登録されている構造PDBオルソログ検索: RCSB PDBe PDBj PDBのIDコード一覧1AB2, 1AWO, 1BBZ, 1JU5, 1OPL, 1ZZP, 2ABL, 2E2B, 2FO0, 2G1T, 2G2F, 2G2H, 2G2I, 2GQG, 2HIW, 2HYY, 2HZ0, 2HZ4, 2HZI, 2V7A, 3CS9, 3EG0, 3EG1, 3EG2, 3EG3, 3EGU, 3K2M, 3QRI, 3QRJ, 3QRK, 3T04, 3UE4, 3UYO, 3PYY, 4J9B, 4J9C, 4J9D, 4J9E, 4J9F, 4J9G, 4J9H, 4J9I, 4JJB, 4JJC, 4JJD, 4TWP, 4WA9, 4XEY, 4YC8, 5DC9, 5DC4, 5DC0, 2O88, 5HU9
識別子
記号 ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, ABL, JTK7, bcr/abl, c-ABL, c-p150, v-abl, CHDSKM, BCR-ABL, Genes, abl
外部ID OMIM: 189980 MGI: 87859 HomoloGene: 3783 GeneCards: ABL1
EC番号 2.7.10.2
遺伝子の位置 (ヒト)染色体9番染色体 (ヒト)[1]バンドデータ無し開始点130,713,016 bp[1]終点130,887,675 bp[1]
遺伝子の位置 (マウス)染色体2番染色体 (マウス)[2]バンドデータ無し開始点31,578,388 bp[2]終点31,694,239 bp[2]
RNA発現パターンさらなる参照発現データ
遺伝子オントロジー分子機能• actin monomer binding• protein domain specific binding• SH3 domain binding• キナーゼ活性• protein C-terminus binding• 受容体結合• ATP binding• protein kinase activity• nicotinate-nucleotide adenylyltransferase activity• non-membrane spanning protein tyrosine kinase activity• 金属イオン結合• proline-rich region binding• magnesium ion binding• トランスフェラーゼ活性• actin filament binding• 血漿タンパク結合• syntaxin binding• protein kinase C binding• DNA結合• ヌクレオチド結合• manganese ion binding• マイトジェン活性化プロテインキナーゼ結合• protein tyrosine kinase activity• four-way junction DNA binding• bubble DNA binding• phosphotyrosine residue binding• transcription coactivator activity• neuropilin binding• SH2 domain binding• ephrin receptor binding• supercoiled DNA binding• sequence-specific double-stranded DNA binding細胞の構成要素• 細胞質• 細胞質基質• 核膜• 膜• extrinsic component of cytoplasmic side of plasma membrane• ミトコンドリア• actin cytoskeleton• perinuclear region of cytoplasm• 細胞骨格• 細胞核• 核小体• 核質• cell leading edge• 核内構造体• 樹状突起• 高分子複合体• neuronal cell body• postsynapse生物学的プロセス• positive regulation of protein phosphorylation• B-1 B cell homeostasis• regulation of axon extension• neuromuscular process controlling balance• positive regulation of muscle cell differentiation• cellular response to DNA damage stimulus• タンパク質リン酸化• regulation of cell adhesion• regulation of microtubule polymerization• DNA damage induced protein phosphorylation• intrinsic apoptotic signaling pathway in response to DNA damage• positive regulation of ERK1 and ERK2 cascade• substrate adhesion-dependent cell spreading• platelet-derived growth factor receptor-beta signaling pathway• positive regulation of actin filament binding• B cell receptor signaling pathway• アポトーシス• negative regulation of endothelial cell apoptotic process• cerebellum morphogenesis• regulation of actin cytoskeleton reorganization• regulation of transcription, DNA-templated• epidermal growth factor receptor signaling pathway• Fc-gamma receptor signaling pathway involved in phagocytosis• タンパク質局在化の確立• 胸腺発生• negative regulation of phospholipase C activity• positive regulation of mitotic cell cycle• actin filament branching• 脾臓発生• 酸化ストレスへの反応• 食作用• positive regulation of peptidyl-tyrosine phosphorylation• regulation of response to DNA damage stimulus• mitochondrial depolarization• positive regulation of Wnt signaling pathway, planar cell polarity pathway• platelet-derived growth factor receptor signaling pathway• regulation of endocytosis• activation of protein kinase C activity• regulation of actin cytoskeleton organization• リン酸化• signal transduction in response to DNA damage• positive regulation of oxidoreductase activity• positive regulation of release of sequestered calcium ion into cytosol• negative regulation of I-kappaB kinase/NF-kappaB signaling• regulation of cell motility• positive regulation of microtubule binding• 細胞接着• regulation of autophagy• peptidyl-tyrosine autophosphorylation• alpha-beta T cell differentiation• regulation of cellular senescence• negative regulation of protein serine/threonine kinase activity• actin cytoskeleton organization• negative regulation of cellular senescence• positive regulation of osteoblast proliferation• 体細胞分裂• activated T cell proliferation• エンドサイトーシス• negative regulation of cell-cell adhesion• B cell proliferation involved in immune response• cellular response to dopamine• positive regulation of cytosolic calcium ion concentration• positive regulation of neuron death• regulation of cell cycle• negative regulation of BMP signaling pathway• オートファジー• B cell proliferation• negative regulation of ubiquitin-protein transferase activity• microspike assembly• positive regulation of apoptotic process• regulation of extracellular matrix organization• positive regulation of I-kappaB kinase/NF-kappaB signaling• negative regulation of ERK1 and ERK2 cascade• transitional one stage B cell differentiation• DNAミスマッチ修復• Bergmann glial cell differentiation• peptidyl-tyrosine phosphorylation• collateral sprouting• cellular response to lipopolysaccharide• negative regulation of mitotic cell cycle• cellular response to hydrogen peroxide• DNA修復• 自然免疫• neural tube closure• post-embryonic development• neuron differentiation• cellular response to oxidative stress• regulation of cell population proliferation• 自己リン酸化• neuroepithelial cell differentiation• integrin-mediated signaling pathway• positive regulation of endothelial cell migration• 細胞分化• regulation of Cdc42 protein signal transduction• neuropilin signaling pathway• endothelial cell migration• regulation of T cell differentiation• positive regulation of transcription by RNA polymerase II• T cell receptor signaling pathway• positive regulation of stress fiber assembly• positive regulation of focal adhesion assembly• DNA conformation change• positive regulation of cell migration involved in sprouting angiogenesis• positive regulation of substrate adhesion-dependent cell spreading• negative regulation of long-term synaptic potentiation• regulation of hematopoietic stem cell differentiation• regulation of modification of synaptic structure• positive regulation of blood vessel branching• positive regulation of actin cytoskeleton reorganization出典:Amigo / QuickGO
オルソログ
種 ヒト マウス
Entrez 25 11350
Ensembl ENSG00000097007 ENSMUSG00000026842
UniProt P00519 P00520
RefSeq(mRNA) NM_007313NM_005157 NM_001112703NM_009594NM_001283045NM_001283046NM_001283047
RefSeq(タンパク質) NP_005148NP_009297 NP_001106174NP_001269974NP_001269975NP_001269976NP_033724
場所(UCSC) Chr 9: 130.71 – 130.89 Mb Chr 9: 31.58 – 31.69 Mb
PubMed検索 [3] [4]
ウィキデータ
閲覧/編集 ヒト閲覧/編集 マウス

ABL1は、ヒトでは9番染色体（英語版）に位置する_ABL1_遺伝子（以前のシンボルは_ABL_）によってコードされているタンパク質である[5]。哺乳類ゲノムに存在するホモログを表す場合にはc-Abl、ウイルスの場合にはv-Ablという表記が用いられることがあり、当初エーベルソンマウス白血病ウイルス（英語版）（Abelson murine leukemia virus）から単離されたことに由来する[6]。

機能

ABL1がん原遺伝子は細胞質と核に位置するチロシンキナーゼ（英語版）をコードし、細胞分化、細胞分裂、細胞接着、そしてDNA修復などのストレス応答といった過程への関与が示唆されている[7][8][9][10]。ABL1タンパク質の活性はSH3ドメインによって負に調節されており、SH3ドメイン領域が欠失することで_ABL1_はがん遺伝子となる。t(9;22)転座は_BCR_遺伝子と_ABL1_遺伝子とのhead-to-tail型の融合を引き起こし、慢性骨髄性白血病の多くの症例でみられる融合遺伝子が形成される。普遍的に発現しているABL1チロシンキナーゼのDNA結合活性はCDC2によるリン酸化によって調節され、このことはABL1が細胞周期機能に関与していることを示唆している。_ABL1_遺伝子は6 kbまたは7 kbのいずれかの長さのmRNA転写産物として発現する。最初のエクソンが選択的エクソンであり、エクソン2–11は共通である[11]。

臨床的意義

第2世代Bcr-Ablチロシンキナーゼ阻害薬ニロチニブ（赤）と複合体を形成したABL1キナーゼドメイン（青）

_ABL1_遺伝子の変異は慢性骨髄性白血病（CML）と関係している。CMLでは、この遺伝子が22番染色体上の_BCR_遺伝子へ転座することによって活性化されている。この染色体異常はCMLに特徴的であり、稀に他の白血病でもみられる。この新たな融合遺伝子_BCR-ABL_は調節を受けない細胞質型チロシンキナーゼをコードし、細胞周期調節システムの媒介因子を活性化することで、サイトカインによる調節を受けることのない細胞増殖を可能にし、クローン性骨髄増殖性疾患を引き起こす。BCR-ABLタンパク質はさまざまな低分子によって阻害することができる。そうした阻害薬の1つとしてイマチニブがあり、チロシンキナーゼドメインに結合してBCR-ABLの細胞周期への影響を阻害する。イマチニブ耐性を持つBCR-ABL変異体を阻害する、次世代型BCR-ABLチロシンキナーゼ阻害薬（英語版）の開発も行われている[12]。

相互作用

ABL1は次に挙げる因子と相互作用することが示されている。

調節

ABL1の発現がmiR-203（英語版）によって調節されている証拠も得られている[61]。

出典

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  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026842 - Ensembl, May 2017
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