25I-NBOMe (original) (raw)
25I-NBOMe (oder 2C-I-NBOMe) ist eine Forschungschemikalie mit halluzinogener und psychedelischer Wirkung, die aufgrund ihrer Struktur zu den Stoffgruppen der Phenolether und der Phenethylamine zählt. Die Wirkung wird unter anderem auf die Eigenschaften des 25I-NBOMes als potenter Agonist am Serotonin-Rezeptores 5-HT2A zurückgeführt. 25I-NBOMe ist ein Derivat des 2C-I.
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| dbo:abstract | 25I-NBOMe (2C-I-NBOMe, Cimbi-5, Smiles and also shortened to "25I") is a synthetic hallucinogen that is used in biochemistry research for mapping the brain's usage of the type 2A serotonin receptor; it is also sometimes used for recreational purposes. A derivative of the substituted phenethylamine 2C-I family, it is the most well-known member of the 25-NB family. It was discovered in 2003 by chemist Ralf Heim at the Free University of Berlin, who published his findings in his PhD dissertation. The compound was subsequently investigated by a team at Purdue University led by David Nichols. The carbon-11 labelled version of 25I-NBOMe, [11C]Cimbi-5, was synthesized and validated as a radiotracer for positron emission tomography (PET) in Copenhagen. Being the first 5-HT2A receptor full agonist PET radioligand, [11C]-CIMBI-5 shows promise as a more functional marker of these receptors, particularly in their high affinity states. Street and media nicknames for this drug are: "N-Bomb", "Solaris", "Smiles", and "Wizard", although the drug is frequently fraudulently sold as LSD. Due to its physical effects and risk of overdose, there have been multiple deaths attributed to the drug. Its long term toxicity is unknown due to lack of existing research. (en) 25I-NBOME (2C-I-NBOME, Cimbi-5) es una droga psicodélica derivada de la feniletilamina sustituida psicodélica . Fue descubierto en 2003 por el químico en la Universidad Libre de Berlín, que publicó sus conclusiones en su tesis doctoral. El compuesto fue posteriormente investigado por un equipo de la Universidad de Purdue dirigido por . La versión marcada con carbono-11 del 25I-NBOME, [11C]CIMBI-5, se sintetizó y se validó como un trazador radioactivo para la tomografía por emisión de positrones (TEP) en Copenhague. Siendo el primer agonista completo del receptor 5-HT2A, para PET, Cimbi-5 promete ser un marcador más funcional de estos receptores, que pueden estar implicados en los trastornos mentales como la depresión y la esquizofrenia. (es) 25I-NBOMe (oder 2C-I-NBOMe) ist eine Forschungschemikalie mit halluzinogener und psychedelischer Wirkung, die aufgrund ihrer Struktur zu den Stoffgruppen der Phenolether und der Phenethylamine zählt. Die Wirkung wird unter anderem auf die Eigenschaften des 25I-NBOMes als potenter Agonist am Serotonin-Rezeptores 5-HT2A zurückgeführt. 25I-NBOMe ist ein Derivat des 2C-I. (de) Le 25I-NBOMe (ou 2C-I-NBOMe, Cimbi-5) est un puissant psychédélique dérivé du 2C-I. Il a été découvert en 2003 par le chimiste Ralf Heim de l'université libre de Berlin, qui a publié ses conclusions dans sa thèse de doctorat. Le composé a ensuite été étudié à l'université de Purdue par David Nichols. (fr) 25I-NBOMe (chiamato anche 2C-I-NBOMe, Cimbi-5 o 25I e colloquialmente come N-Bomb, Solaris, Smiles o Wizard) è una fenitilammina psichedelica oggi utilizzata nella ricerca biochimica per mappare l'uso del cervello del recettore della serotonina di tipo 2A; a volte è anche usata per scopi ricreativi, sebbene presenti rischi considerevolmente più elevati rispetto agli psichedelici classici; nel mercato nero è infatti spesso spacciata per LSD, mescalina o altri psichedelici piuttosto che venduta col suo nome. È un derivato della fenetilammina 2C-I ed è il membro più noto della famiglia dei . È stato scoperto nel 2003 dal chimico della Università di Berlino, che ha pubblicato i suoi risultati nella sua tesi di dottorato. Il composto è stato successivamente esaminato da un team di Università Purdue guidata da David Nichols. È una sostanza molto pericolosa per via delle frequentissime neuropatie di ritorno e la vasocostrizione che generalmente arreca. (it) 25I-NBOMe (2C-I-NBOMe, Cimbi-5, abreviada como 25i) é uma droga psicodélica, descoberta em 2003 pelo químico Ralf Heim da Universidade de Berlim. Foi classificada como droga ilícita pela União Europeia em 25 de setembro de 2014, por não possuir propósito médico ou legítimo. (pt) 25I-NBOMe (2C-I-NBOMe) — психоактивное вещество из класса , производное от 2C-I, синтезированное в 2003 году Ральфом Хеймом (Ralf Heim) в Свободном университете Берлина, в рамках кандидатской диссертации по теме синтеза и фармакологии агонистов серотониновых рецепторов 5-HT2A. 25I-NBOMe действует как сильный полный (селективный) агонист человеческого рецептора 5-HT2A, с Ki равным 0,044 nM, что делает это вещество в 16 раз более активным, чем 2C-I. Также помеченная изотопами форма 25I-NBOMe может быть использована для создания топографии размещения рецепторов 5-HT2A в мозге. Впоследствии вещество изучалось командой университета Пердью под руководством . (ru) |
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| rdfs:comment | 25I-NBOMe (oder 2C-I-NBOMe) ist eine Forschungschemikalie mit halluzinogener und psychedelischer Wirkung, die aufgrund ihrer Struktur zu den Stoffgruppen der Phenolether und der Phenethylamine zählt. Die Wirkung wird unter anderem auf die Eigenschaften des 25I-NBOMes als potenter Agonist am Serotonin-Rezeptores 5-HT2A zurückgeführt. 25I-NBOMe ist ein Derivat des 2C-I. (de) Le 25I-NBOMe (ou 2C-I-NBOMe, Cimbi-5) est un puissant psychédélique dérivé du 2C-I. Il a été découvert en 2003 par le chimiste Ralf Heim de l'université libre de Berlin, qui a publié ses conclusions dans sa thèse de doctorat. Le composé a ensuite été étudié à l'université de Purdue par David Nichols. (fr) 25I-NBOMe (2C-I-NBOMe, Cimbi-5, abreviada como 25i) é uma droga psicodélica, descoberta em 2003 pelo químico Ralf Heim da Universidade de Berlim. Foi classificada como droga ilícita pela União Europeia em 25 de setembro de 2014, por não possuir propósito médico ou legítimo. (pt) 25I-NBOMe (2C-I-NBOMe, Cimbi-5, Smiles and also shortened to "25I") is a synthetic hallucinogen that is used in biochemistry research for mapping the brain's usage of the type 2A serotonin receptor; it is also sometimes used for recreational purposes. A derivative of the substituted phenethylamine 2C-I family, it is the most well-known member of the 25-NB family. It was discovered in 2003 by chemist Ralf Heim at the Free University of Berlin, who published his findings in his PhD dissertation. The compound was subsequently investigated by a team at Purdue University led by David Nichols. (en) 25I-NBOME (2C-I-NBOME, Cimbi-5) es una droga psicodélica derivada de la feniletilamina sustituida psicodélica . Fue descubierto en 2003 por el químico en la Universidad Libre de Berlín, que publicó sus conclusiones en su tesis doctoral. El compuesto fue posteriormente investigado por un equipo de la Universidad de Purdue dirigido por . (es) 25I-NBOMe (chiamato anche 2C-I-NBOMe, Cimbi-5 o 25I e colloquialmente come N-Bomb, Solaris, Smiles o Wizard) è una fenitilammina psichedelica oggi utilizzata nella ricerca biochimica per mappare l'uso del cervello del recettore della serotonina di tipo 2A; a volte è anche usata per scopi ricreativi, sebbene presenti rischi considerevolmente più elevati rispetto agli psichedelici classici; nel mercato nero è infatti spesso spacciata per LSD, mescalina o altri psichedelici piuttosto che venduta col suo nome. È un derivato della fenetilammina 2C-I ed è il membro più noto della famiglia dei . È stato scoperto nel 2003 dal chimico della Università di Berlino, che ha pubblicato i suoi risultati nella sua tesi di dottorato. Il composto è stato successivamente esaminato da un team di Università P (it) 25I-NBOMe (2C-I-NBOMe) — психоактивное вещество из класса , производное от 2C-I, синтезированное в 2003 году Ральфом Хеймом (Ralf Heim) в Свободном университете Берлина, в рамках кандидатской диссертации по теме синтеза и фармакологии агонистов серотониновых рецепторов 5-HT2A. 25I-NBOMe действует как сильный полный (селективный) агонист человеческого рецептора 5-HT2A, с Ki равным 0,044 nM, что делает это вещество в 16 раз более активным, чем 2C-I. Также помеченная изотопами форма 25I-NBOMe может быть использована для создания топографии размещения рецепторов 5-HT2A в мозге. (ru) |
| rdfs:label | 25I-NBOMe (de) 25I-NBOMe (en) 25I-NBOMe (es) 25I-NBOMe (it) 25I-NBOMe (fr) 25I-NBOMe (pt) 25I-NBOMe (ru) |
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