5-HT3 receptor (original) (raw)
El receptor 5-HT 3 és un receptor ionòtrop activat per la serotonina que pertany a la família dels receptors cys-loop, com el receptor GABAA, el receptor de l'acetilcolina i el receptor de la glicina. Es troba a la regió del cervell dita CTZ (chemoreceptor trigger zone), al quart ventrícul, que provoca el reflex de la nàusea. El canal és específicament inhibit per l'ondansetró que és un antiemètic utilitzat per evitar l'estat de nàusea associat a la teràpia anticancerosa.
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| dbo:abstract | El receptor 5-HT 3 és un receptor ionòtrop activat per la serotonina que pertany a la família dels receptors cys-loop, com el receptor GABAA, el receptor de l'acetilcolina i el receptor de la glicina. Es troba a la regió del cervell dita CTZ (chemoreceptor trigger zone), al quart ventrícul, que provoca el reflex de la nàusea. El canal és específicament inhibit per l'ondansetró que és un antiemètic utilitzat per evitar l'estat de nàusea associat a la teràpia anticancerosa. (ca) The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors. This ion channel is cation-selective and mediates neuronal depolarization and excitation within the central and peripheral nervous systems. As with other ligand gated ion channels, the 5-HT3 receptor consists of five subunits arranged around a central ion conducting pore, which is permeable to sodium (Na), potassium (K), and calcium (Ca) ions. Binding of the neurotransmitter 5-hydroxytryptamine (serotonin) to the 5-HT3 receptor opens the channel, which, in turn, leads to an excitatory response in neurons. The rapidly activating, desensitizing, inward current is predominantly carried by sodium and potassium ions. 5-HT3 receptors have a negligible permeability to anions. They are most closely related by homology to the nicotinic acetylcholine receptor. (en) Le récepteur 5-HT3 est un récepteur ionotrope activé par la sérotonine qui appartient à la famille de récepteur cys-loop, comme le récepteur GABAA, le récepteur à l'acétylcholine et le récepteur à la glycine. Il est retrouvé dans la région du cerveau nommée CTZ (Chimioreceptive Trigger Zone), dans le plancher du 4e ventricule, qui déclenche le réflexe nauséeux. Le canal est spécifiquement inhibé par l'ondansétron qui est un anti émétique utilisé pour éviter l'état nauséeux associé à la thérapie anticancéreuse. (fr) 5-HT3-рецептор, сокр. 5-HT3 — подтип серотониновых рецепторов, который относится к суперсемейству цис-петлевых лиганд-зависимых ионных каналов (ионотропных рецепторов) и поэтому структурно и функционально отличается от всех других рецепторов 5-HT-рецепторов (5-гидрокситриптамина или серотонина), которые являются рецепторами, сопряжённые с G-белком (GPCR). 5-HT3 представляет собой селективный катионный канал, он обеспечивает деполяризацию и возбуждение нейронов в центральной и периферической нервной системе. Как и в случае других лиганд-управляемых ионных каналов, рецептор 5-HT3 состоит из пяти субъединиц, расположенных вокруг центральной ионопроводящей поры, которая проницаема для ионов натрия (Na+), калия (K+) и кальция (Ca2+). Связывание нейромедиатора 5-гидрокситриптамина (серотонина) с рецептором 5-HT3 открывает канал, что, в свою очередь, приводит к возбуждающему ответу в нейронах (потенциалу действия). 5-HT3-рецепторы имеют незначительную проницаемость для анионов. По структуре они наиболее гомологичны с никотиновыми рецепторами ацетилхолина. (ru) O receptor 5-HT3 pertence à de canais de íons ligados a ligandos (abreviados na literatura em inglês LGICs, de ligand-gated ion channels) e, portanto, difere estrutural e funcionalmente de todos os outros receptores receptores 5-HT (5-hidroxitriptamina ou serotonina) os quais receptores acoplados à proteína G. Este canal de íon é seletivo para cátions e media a despolarização e excitação neuronal dentro dos sistemas nervosos central e periférico. (pt) Receptor 5-HT3, receptor serotoninowy 3 – receptor jonotropowy składający się z pięciu jednostek, kodowanych u człowieka genem 5HTR3A, należący do rodziny receptorów serotoninowych. (pl) |
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| rdfs:comment | El receptor 5-HT 3 és un receptor ionòtrop activat per la serotonina que pertany a la família dels receptors cys-loop, com el receptor GABAA, el receptor de l'acetilcolina i el receptor de la glicina. Es troba a la regió del cervell dita CTZ (chemoreceptor trigger zone), al quart ventrícul, que provoca el reflex de la nàusea. El canal és específicament inhibit per l'ondansetró que és un antiemètic utilitzat per evitar l'estat de nàusea associat a la teràpia anticancerosa. (ca) Le récepteur 5-HT3 est un récepteur ionotrope activé par la sérotonine qui appartient à la famille de récepteur cys-loop, comme le récepteur GABAA, le récepteur à l'acétylcholine et le récepteur à la glycine. Il est retrouvé dans la région du cerveau nommée CTZ (Chimioreceptive Trigger Zone), dans le plancher du 4e ventricule, qui déclenche le réflexe nauséeux. Le canal est spécifiquement inhibé par l'ondansétron qui est un anti émétique utilisé pour éviter l'état nauséeux associé à la thérapie anticancéreuse. (fr) O receptor 5-HT3 pertence à de canais de íons ligados a ligandos (abreviados na literatura em inglês LGICs, de ligand-gated ion channels) e, portanto, difere estrutural e funcionalmente de todos os outros receptores receptores 5-HT (5-hidroxitriptamina ou serotonina) os quais receptores acoplados à proteína G. Este canal de íon é seletivo para cátions e media a despolarização e excitação neuronal dentro dos sistemas nervosos central e periférico. (pt) Receptor 5-HT3, receptor serotoninowy 3 – receptor jonotropowy składający się z pięciu jednostek, kodowanych u człowieka genem 5HTR3A, należący do rodziny receptorów serotoninowych. (pl) The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors. This ion channel is cation-selective and mediates neuronal depolarization and excitation within the central and peripheral nervous systems. (en) 5-HT3-рецептор, сокр. 5-HT3 — подтип серотониновых рецепторов, который относится к суперсемейству цис-петлевых лиганд-зависимых ионных каналов (ионотропных рецепторов) и поэтому структурно и функционально отличается от всех других рецепторов 5-HT-рецепторов (5-гидрокситриптамина или серотонина), которые являются рецепторами, сопряжённые с G-белком (GPCR). 5-HT3 представляет собой селективный катионный канал, он обеспечивает деполяризацию и возбуждение нейронов в центральной и периферической нервной системе. (ru) |
| rdfs:label | Receptor 5-HT3 (ca) 5-HT3 receptor (en) Récepteur 5-HT3 (fr) Receptor 5-HT3 (pl) Receptor 5-HT3 (pt) 5-HT3 (ru) |
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