| dbo:abstract |
Ein AT-Haken ist eine DNA-bindende Domäne in verschiedenen DNA-bindenden Proteinen. (de) The AT-hook is a DNA-binding motif present in many proteins, including the high mobility group (HMG) proteins, DNA-binding proteins from plants and hBRG1 protein, a central ATPase of the human switching/sucrose non-fermenting (SWI/SNF) remodeling complex. This motif consists of a conserved, palindromic, core sequence of proline-arginine-glycine-arginine-proline, although some AT-hooks contain only a single proline in the core sequence. AT-hooks also include a variable number of positively charged lysine and arginine residues on either side of the core sequence. The AT-hook binds to the minor groove of adenine-thymine (AT) rich DNA, hence the AT in the name. The rest of the name derives from a predicted asparagine/aspartate "hook" in the earliest AT-hooks reported in 1990. In 1997 structural studies using NMR determined that a DNA-bound AT-hook adopted a crescent or hook shape around the minor groove of a target DNA strand (pictured at right). HMGA proteins contain three AT-hooks, although some proteins contain as many as 30. The optimal binding sequences for AT-hook proteins are repeats of the form (ATAA)n or (TATT)n, although the optimal binding sequences for the core sequence of the AT-hook are AAAT and AATT. (en) |
| dbo:symbol |
AT_hook |
| dbo:thumbnail |
wiki-commons:Special:FilePath/PDB_2eze_EBI.jpg?width=300 |
| dbo:wikiPageID |
21801799 (xsd:integer) |
| dbo:wikiPageLength |
4987 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1060778014 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Proline dbr:NMR dbr:Structural_motif dbr:Homo_sapiens dbr:DNA-binding_domain dbc:Molecular_genetics dbr:Glycine dbr:Lysine dbr:Thymine dbr:Adenine dbr:Protein_complex dbr:Protein dbr:Arginine dbr:Asparagine dbc:Genetics_techniques dbr:Plants dbr:Minor_groove dbr:Aspartate dbr:High_mobility_group dbr:File:AT-hook.png |
| dbp:caption |
solution structure of a complex of the second dna binding domain of human hmg-i bound to dna dodecamer containing the prdii site of the interferon-beta promoter, nmr, 35 structures (en) |
| dbp:interpro |
IPR017956 (en) |
| dbp:name |
AT-hook (en) |
| dbp:pfam |
PF02178 (en) |
| dbp:scop |
2 (xsd:integer) |
| dbp:smart |
AT_hook (en) |
| dbp:symbol |
AT_hook (en) |
| dbp:wikiPageUsesTemplate |
dbt:Infobox_protein_family dbt:Reflist dbt:Molecular-cell-biology-stub |
| dcterms:subject |
dbc:Molecular_genetics dbc:Genetics_techniques |
| gold:hypernym |
dbr:Motif |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 |
| rdfs:comment |
Ein AT-Haken ist eine DNA-bindende Domäne in verschiedenen DNA-bindenden Proteinen. (de) The AT-hook is a DNA-binding motif present in many proteins, including the high mobility group (HMG) proteins, DNA-binding proteins from plants and hBRG1 protein, a central ATPase of the human switching/sucrose non-fermenting (SWI/SNF) remodeling complex. (en) |
| rdfs:label |
AT-hook (en) AT-Haken (de) |
| owl:sameAs |
freebase:AT-hook wikidata:AT-hook dbpedia-de:AT-hook dbpedia-gl:AT-hook https://global.dbpedia.org/id/2KWA3 |
| prov:wasDerivedFrom |
wikipedia-en:AT-hook?oldid=1060778014&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/AT-hook.png wiki-commons:Special:FilePath/PDB_2eze_EBI.jpg |
| foaf:isPrimaryTopicOf |
wikipedia-en:AT-hook |
| is dbo:wikiPageRedirects of |
dbr:AT_hook |
| is dbo:wikiPageWikiLink of |
dbr:Methyl-CpG-binding_domain dbr:Proline-rich_12 dbr:HMGA dbr:HMGA1 dbr:HMGA2 dbr:Floating–Harbor_syndrome dbr:KMT2C dbr:AHCTF1 dbr:ERCC1 dbr:AKNA dbr:High-mobility_group dbr:PATZ1 dbr:CD40_(protein) dbr:Cancer_epigenetics dbr:PSIP1 dbr:AT_hook |
| is foaf:primaryTopic of |
wikipedia-en:AT-hook |
