AlkD (original) (raw)
AlkD (Alkylpurine glycosylase D) is an enzyme belonging to a family of DNA glycosylases that are involved in DNA repair. It was discovered by a team of Norwegian biologists from Oslo in 2006. It was isolated from a soil-dwelling Gram-positive bacteria Bacillus cereus, along with another enzyme AlkC. AlkC and AlkD are most probably derived from the same protein as indicated by their close resemblance. They are also found in other prokaryotes. Among eukaryotes, they are found only in the single-celled species only, such as Entamoeba histolytica and Dictyostelium discoideum. The enzyme specifically targets 7mG (methyl-guanine) in the DNA, and is, therefore, unique among DNA glycosylases. It can also act on other methylpurines with less affinity. It indicates that the enzyme is specific for lo
| Property | Value |
|---|---|
| dbo:abstract | AlkD (Alkylpurine glycosylase D) is an enzyme belonging to a family of DNA glycosylases that are involved in DNA repair. It was discovered by a team of Norwegian biologists from Oslo in 2006. It was isolated from a soil-dwelling Gram-positive bacteria Bacillus cereus, along with another enzyme AlkC. AlkC and AlkD are most probably derived from the same protein as indicated by their close resemblance. They are also found in other prokaryotes. Among eukaryotes, they are found only in the single-celled species only, such as Entamoeba histolytica and Dictyostelium discoideum. The enzyme specifically targets 7mG (methyl-guanine) in the DNA, and is, therefore, unique among DNA glycosylases. It can also act on other methylpurines with less affinity. It indicates that the enzyme is specific for locating and cutting (excision) of chemically modified bases from DNA, exactly at 7mG, whenever there are errors in replication. It accelerates the rate of 7mG hydrolysis 100-fold over the spontaneous depurination. Thus, it protects the genome from harmful changes induced by chemical and environmental agents. Its crystal structure was described in 2008. It is the first HEAT repeat protein identified to interact with nucleic acids or to contain enzymatic activity. (en) AlkD (alquilpurina glicosilase D) é uma enzima que pertencente a uma família de glicosilase de ADN que está envolvida na reparação do ADN. Ela foi descoberta por uma equipe de biólogos norueguesa de Oslo em 2006. Ela foi isolado a partir de uma bactéria Bacillus cereus Gram-positiva que habita o solo, junto com uma outra enzima AlkC. AlkC e AlkD são muito provavelmente derivadas da mesma proteína, como indicado pela sua grande semelhança. A sua estrutura cristalina foi descrita em 2008. Ela é a primeira identificada para interagir com ácidos nucleicos ou para conter a actividade enzimática. Esse tipo de enzima de reparação do ADN pode identificar e remover uma base de ADN danificado, sem forçar fisicamente o "giro" para o exterior da estrutura de ADN, que é como todas as outras enzimas de reparação de ADN nessa famila funcionam. (pt) |
| dbo:thumbnail | wiki-commons:Special:FilePath/AlkD_recognizes_DNA.png?width=300 |
| dbo:wikiPageID | 48430909 (xsd:integer) |
| dbo:wikiPageLength | 6038 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 958672264 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Entamoeba_histolytica dbr:Prokaryote dbr:Alkylation dbr:DNA_glycosylase dbr:DNA_repair dbr:DNA_replication dbr:Nucleic_acid dbr:Enzyme dbr:Crystal_structure dbr:Aromaticity dbr:Helix dbr:Amino_acid dbr:Eukaryote dbr:Oslo dbr:Dictyostelium_discoideum dbr:Gram-positive_bacteria dbc:DNA_repair dbr:Guanine dbr:Bacillus_cereus dbr:Hydrolysis dbr:Atomic_mass_unit dbc:Hydrolases dbr:HEAT_repeat_domain dbr:Nucleic_acid_structure dbr:Protozoa dbr:File:AlkD_recognizes_DNA.png dbr:File:AlkD_with_DNA.tif |
| dbp:wikiPageUsesTemplate | dbt:Reflist |
| dcterms:subject | dbc:DNA_repair dbc:Hydrolases |
| gold:hypernym | dbr:Enzyme |
| rdf:type | dbo:Protein |
| rdfs:comment | AlkD (Alkylpurine glycosylase D) is an enzyme belonging to a family of DNA glycosylases that are involved in DNA repair. It was discovered by a team of Norwegian biologists from Oslo in 2006. It was isolated from a soil-dwelling Gram-positive bacteria Bacillus cereus, along with another enzyme AlkC. AlkC and AlkD are most probably derived from the same protein as indicated by their close resemblance. They are also found in other prokaryotes. Among eukaryotes, they are found only in the single-celled species only, such as Entamoeba histolytica and Dictyostelium discoideum. The enzyme specifically targets 7mG (methyl-guanine) in the DNA, and is, therefore, unique among DNA glycosylases. It can also act on other methylpurines with less affinity. It indicates that the enzyme is specific for lo (en) AlkD (alquilpurina glicosilase D) é uma enzima que pertencente a uma família de glicosilase de ADN que está envolvida na reparação do ADN. Ela foi descoberta por uma equipe de biólogos norueguesa de Oslo em 2006. Ela foi isolado a partir de uma bactéria Bacillus cereus Gram-positiva que habita o solo, junto com uma outra enzima AlkC. AlkC e AlkD são muito provavelmente derivadas da mesma proteína, como indicado pela sua grande semelhança. A sua estrutura cristalina foi descrita em 2008. Ela é a primeira identificada para interagir com ácidos nucleicos ou para conter a actividade enzimática. Esse tipo de enzima de reparação do ADN pode identificar e remover uma base de ADN danificado, sem forçar fisicamente o "giro" para o exterior da estrutura de ADN, que é como todas as outras enzimas de (pt) |
| rdfs:label | AlkD (en) AlkD (pt) |
| owl:sameAs | wikidata:AlkD dbpedia-pt:AlkD https://global.dbpedia.org/id/22DFw |
| prov:wasDerivedFrom | wikipedia-en:AlkD?oldid=958672264&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/AlkD_recognizes_DNA.png |
| foaf:isPrimaryTopicOf | wikipedia-en:AlkD |
| is dbo:wikiPageRedirects of | dbr:Alkylpurine_glycosylase_D |
| is dbo:wikiPageWikiLink of | dbr:DNA_glycosylase dbr:Bacillus_cereus dbr:Alkylpurine_glycosylase_D |
| is foaf:primaryTopic of | wikipedia-en:AlkD |
