Amentoflavone (original) (raw)
L'amentoflavone è un flavone presente in numerose piante tra cui Ginkgo biloba, Chamaecyparis obtusa, Hypericum perforatum e Xerophyta plicata.
| Property | Value |
|---|---|
| dbo:abstract | Amentoflavone is a biflavonoid (bis-apigenin coupled at 8 and 3' positions, or 3′,8′′-biapigenin) constituent of a number of plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Hypericum perforatum (St. John's Wort) and Xerophyta plicata. Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body. It is also an inhibitor of human cathepsin B. Amentoflavone has a variety of in vitro activities including antimalarial activity, anticancer activity (which may, at least in part, be mediated by its inhibition of fatty acid synthase), and antagonist activity at the κ-opioid receptor (Ke = 490 nmol L−1) as well as activity at the allosteric benzodiazepine site of the GABAA receptor as a negative allosteric modulator. (en) Amentoflavona es un biflavonoide (bis-apigenina) constitutivo de un número de plantas, incluyendo Ginkgo biloba, Chamaecyparis obtusa, Hypericum perforatum) y Xerophyta plicata. Amentoflavona puede interactuar con muchos medicamentos por ser un potente inhibidor de CYP3A4 y CYP2C9, que son las enzimas responsables del metabolismo de algunos fármacos en el organismo. También es un inhibidor de la catepsina B humana. Amentoflavona tiene una variedad de actividades in vitro, incluyendo actividad antimalárica, actividad contra el cáncer (que puede, al menos en parte, ser mediada por su inhibición de la sintasa de ácidos grasos ), y afinidades por los receptores opioides (como un antagonista) y por el sitio alostérico (benzodiazepina) en el como modulador alostérico negativo. (es) L'amentoflavone è un flavone presente in numerose piante tra cui Ginkgo biloba, Chamaecyparis obtusa, Hypericum perforatum e Xerophyta plicata. (it) |
| dbo:alternativeName | Didemethyl-ginkgetin (en) 3′,8′′-Biapigenin (en) |
| dbo:iupacName | (4′,5,7-Trihydroxyflavone)-(3′→8)-(4′,5,7-trihydroxyflavone) (en) 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Amentoflavone.svg?width=300 |
| dbo:wikiPageID | 26370272 (xsd:integer) |
| dbo:wikiPageLength | 6358 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1051002066 (xsd:integer) |
| dbo:wikiPageWikiLink | dbc:Cytochrome_P450_inhibitors dbc:Natural_phenol_dimers dbr:Allosteric_regulation dbr:Hypericum_perforatum dbr:In_vitro dbc:GABAA_receptor_negative_allosteric_modulators dbc:Resorcinols dbr:Enzyme dbr:Ginkgo_biloba dbr:Molar_concentration dbr:Apigenin dbr:Fatty_acid_synthase dbr:Receptor_antagonist dbr:Drug_metabolism dbr:GABAA_receptor dbc:Flavones dbc:Kappa-opioid_receptor_antagonists dbr:CYP2C9 dbr:CYP3A4 dbr:Cathepsin_B dbr:Chamaecyparis_obtusa dbr:Κ-opioid_receptor dbr:Xerophyta_plicata dbr:Benzodiazepine_site dbr:Negative_allosteric_modulator |
| dbp:imagealt | Skeletal formula (en) Ball-and-stick model of amentoflavone (en) |
| dbp:imagefile | Amentoflavone molecule ball.png (en) Amentoflavone.svg (en) |
| dbp:imagesize | 220 (xsd:integer) |
| dbp:iupacname | -- (en) |
| dbp:othernames | 3 (xsd:integer) Didemethyl-ginkgetin (en) |
| dbp:pin | 8 (xsd:integer) |
| dbp:verifiedrevid | 403346640 (xsd:integer) |
| dbp:watchedfields | changed (en) |
| dbp:wikiPageUsesTemplate | dbt:Flavones dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:GABA_receptor_modulators dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Opioid_receptor_modulators |
| dct:subject | dbc:Cytochrome_P450_inhibitors dbc:Natural_phenol_dimers dbc:GABAA_receptor_negative_allosteric_modulators dbc:Resorcinols dbc:Flavones dbc:Kappa-opioid_receptor_antagonists |
| gold:hypernym | dbr:Constituent |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatNaturalPhenolDimers yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Dimer114835569 yago:Flavone114869513 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound yago:Resorcinol115004715 yago:Substance100019613 yago:WikicatFlavones yago:WikicatResorcinols umbel-rc:ChemicalSubstanceType |
| rdfs:comment | L'amentoflavone è un flavone presente in numerose piante tra cui Ginkgo biloba, Chamaecyparis obtusa, Hypericum perforatum e Xerophyta plicata. (it) Amentoflavone is a biflavonoid (bis-apigenin coupled at 8 and 3' positions, or 3′,8′′-biapigenin) constituent of a number of plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Hypericum perforatum (St. John's Wort) and Xerophyta plicata. Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body. It is also an inhibitor of human cathepsin B. (en) Amentoflavona es un biflavonoide (bis-apigenina) constitutivo de un número de plantas, incluyendo Ginkgo biloba, Chamaecyparis obtusa, Hypericum perforatum) y Xerophyta plicata. Amentoflavona puede interactuar con muchos medicamentos por ser un potente inhibidor de CYP3A4 y CYP2C9, que son las enzimas responsables del metabolismo de algunos fármacos en el organismo. También es un inhibidor de la catepsina B humana. (es) |
| rdfs:label | Amentoflavone (en) Amentoflavona (es) Amentoflavone (it) |
| owl:sameAs | freebase:Amentoflavone yago-res:Amentoflavone wikidata:Amentoflavone http://azb.dbpedia.org/resource/آمنتوفلاون dbpedia-es:Amentoflavone dbpedia-fa:Amentoflavone dbpedia-it:Amentoflavone dbpedia-sh:Amentoflavone dbpedia-sr:Amentoflavone https://global.dbpedia.org/id/4PQ8T |
| prov:wasDerivedFrom | wikipedia-en:Amentoflavone?oldid=1051002066&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Amentoflavone.svg wiki-commons:Special:FilePath/Amentoflavone_molecule_ball.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Amentoflavone |
| is dbo:wikiPageWikiLink of | dbr:Prostaglandin_D2 dbr:List_of_cytochrome_P450_modulators dbr:Hypericum_perforatum dbr:List_of_opioids dbr:Pawhuskin_A dbr:Γ-Aminobutyric_acid dbr:Leycesteria_formosa dbr:Apigenin dbr:GABAA_receptor dbr:GABAA_receptor_negative_allosteric_modulator dbr:Hypericum_olympicum dbr:Biflavonoid dbr:Biophytum_sensitivum dbr:C30H18O10 dbr:CYP2C9 dbr:Chamaecyparis_obtusa dbr:Κ-opioid_receptor dbr:Nanuza_plicata |
| is foaf:primaryTopic of | wikipedia-en:Amentoflavone |
