Pawhuskin A (original) (raw)
Pawhuskin A is a naturally occurring prenylated stilbene isolated from Dalea purpurea which acts as a competitive silent antagonist of the κ-, μ-, and δ-opioid receptors (Ke = 203 nM, 570 nM, and 2900 nM, respectively). The compound was named after Pawhuska, Oklahoma, a place near where the samples of Dalea purpurea that led to its discovery were taken from. Other isolates of the plant with affinity for opioid receptors include and , though these compounds produce comparatively weak opioid receptor displacement (4.2–11.4 μM) relative to Pawhuskin A. Dalea purpurea was used in traditional Native American medicine to treat various ailments, and pawhuskin A and related isolates may be some of the constituents of the plant which underlay this use.
| Property | Value |
|---|---|
| dbo:abstract | Pawhuskin A is a naturally occurring prenylated stilbene isolated from Dalea purpurea which acts as a competitive silent antagonist of the κ-, μ-, and δ-opioid receptors (Ke = 203 nM, 570 nM, and 2900 nM, respectively). The compound was named after Pawhuska, Oklahoma, a place near where the samples of Dalea purpurea that led to its discovery were taken from. Other isolates of the plant with affinity for opioid receptors include and , though these compounds produce comparatively weak opioid receptor displacement (4.2–11.4 μM) relative to Pawhuskin A. Dalea purpurea was used in traditional Native American medicine to treat various ailments, and pawhuskin A and related isolates may be some of the constituents of the plant which underlay this use. (en) |
| dbo:iupacName | 4-[(E)-2-{2-[(2E)-3,7-Dimethylocta-2,6-dien-1-yl]-3,5-dihydroxyphenyl}ethen-1-yl]-3-(3-methylbut-2-en-1-yl)benzene-1,2-diol (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/pawhuskin_A.svg?width=300 |
| dbo:wikiPageID | 44907328 (xsd:integer) |
| dbo:wikiPageLength | 3649 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1051582435 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Catechin dbr:Salvinorin_A dbr:Hyperoside dbr:Pawhuska,_Oklahoma dbr:Δ-opioid_receptor dbc:Stilbenoids dbr:Competitive_antagonist dbr:Natural_product dbr:Opioid_receptor dbc:Mu-opioid_receptor_antagonists dbr:Receptor_antagonist dbr:Prenylation dbr:Amentoflavone dbc:Kappa-opioid_receptor_antagonists dbr:Dalea_purpurea dbr:Μ-opioid_receptor dbc:Delta-opioid_receptor_antagonists dbr:Affinity_(pharmacology) dbr:Κ-opioid_receptor dbr:Native_American_ethnobotany dbr:Stilbene dbr:Silent_antagonist dbr:Pawhuskin_B dbr:Pawhuskin_C |
| dbp:imagealt | Skeletal formula (en) Ball-and-stick model of pawhuskin A (en) |
| dbp:imagefile | Pawhuskin A molecule ball.png (en) pawhuskin A.svg (en) |
| dbp:imagesize | 220 (xsd:integer) |
| dbp:pin | 4 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Organic-compound-stub dbt:Reflist dbt:Opioid_receptor_modulators |
| dcterms:subject | dbc:Stilbenoids dbc:Mu-opioid_receptor_antagonists dbc:Kappa-opioid_receptor_antagonists dbc:Delta-opioid_receptor_antagonists |
| gold:hypernym | dbr:Stilbene |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | Pawhuskin A is a naturally occurring prenylated stilbene isolated from Dalea purpurea which acts as a competitive silent antagonist of the κ-, μ-, and δ-opioid receptors (Ke = 203 nM, 570 nM, and 2900 nM, respectively). The compound was named after Pawhuska, Oklahoma, a place near where the samples of Dalea purpurea that led to its discovery were taken from. Other isolates of the plant with affinity for opioid receptors include and , though these compounds produce comparatively weak opioid receptor displacement (4.2–11.4 μM) relative to Pawhuskin A. Dalea purpurea was used in traditional Native American medicine to treat various ailments, and pawhuskin A and related isolates may be some of the constituents of the plant which underlay this use. (en) |
| rdfs:label | Pawhuskin A (en) |
| owl:sameAs | freebase:Pawhuskin A yago-res:Pawhuskin A wikidata:Pawhuskin A https://global.dbpedia.org/id/sCTW |
| prov:wasDerivedFrom | wikipedia-en:Pawhuskin_A?oldid=1051582435&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Pawhuskin_A_molecule_ball.png wiki-commons:Special:FilePath/pawhuskin_A.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Pawhuskin_A |
| is dbo:wikiPageRedirects of | dbr:Pawhuskin |
| is dbo:wikiPageWikiLink of | dbr:Dalea_purpurea dbr:C29H36O4 dbr:Κ-opioid_receptor dbr:Pawhuskin |
| is foaf:primaryTopic of | wikipedia-en:Pawhuskin_A |
