Ankyrin repeat (original) (raw)
The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. Domains consisting of ankyrin tandem repeats mediate protein–protein interactions and are among the most common structural motifs in known proteins. They appear in bacterial, archaeal, and eukaryotic proteins, but are far more common in eukaryotes. Ankyrin repeat proteins, though absent in most viruses, are common among poxviruses. Most proteins that contain the motif have four to six repeats, although its namesake ankyrin contains 24, and the largest known number of repeats is 34, predicted in a protein expressed by Giardia lamblia.
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| dbo:abstract | The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. Domains consisting of ankyrin tandem repeats mediate protein–protein interactions and are among the most common structural motifs in known proteins. They appear in bacterial, archaeal, and eukaryotic proteins, but are far more common in eukaryotes. Ankyrin repeat proteins, though absent in most viruses, are common among poxviruses. Most proteins that contain the motif have four to six repeats, although its namesake ankyrin contains 24, and the largest known number of repeats is 34, predicted in a protein expressed by Giardia lamblia. Ankyrin repeats typically fold together to form a single, linear solenoid structure called ankyrin repeat domains. These domains are one of the most common protein–protein interaction platforms in nature. They occur in a large number of functionally diverse proteins, mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell cycle regulators, cytoskeletal, ion transporters, and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function, since there is no specific sequence or structure that is universally recognised by it. Considering the atomic structures of individual ankyrin repeats, the loop is often a type 1 beta bulge loop, while both alpha-helices commonly have a Schellman loop at their N-terminus. (en) Une répétition ankyrine est une configuration particulière des protéines consistant en 33 résidus d'acides aminés formant deux hélices α séparées par des boucles. Ces domaines sont très répandus, un peu chez les bactéries et les archées, mais surtout chez les eucaryotes. Ils sont absents de la plupart des virus, à l'exception des Poxviridae. Ils sont définis par leur structure et non par leur séquence dans la mesure où aucune séquence particulière n'a été associée aux répétitions ankyrine. La plupart des protéines qui contiennent ce type de structures possèdent de quatre à six répétitions ankyrine, l'ankyrine elle-même en ayant 24, le record étant probablement les 34 répétitions d'une protéine exprimée par Giardia lamblia. Les répétitions ankyrine se replient généralement ensemble pour former une structure unique en forme de solénoïde linéaire appelée domaine de répétitions ankyrine. Ces domaines constituent l'une des plateformes les plus courantes assurant les interactions protéine-protéine. Elles interviennent dans un grand nombre de protéines aux fonctions diverses, principalement chez les eucaryotes. Les exemples provenant de procaryotes et de virus résultent peut-être de transferts horizontaux de gènes. Cette structure a été observée dans des protéines assurant des fonctions très diverses, comme l'initiation de la transcription, la régulation du cycle cellulaire, le transport d'ions, la transduction de signal et les protéines du cytosquelette. (fr) |
| dbo:symbol | Ank |
| dbo:thumbnail | wiki-commons:Special:FilePath/Ankyrin_R_membrane-binding_domain_1N11.png?width=300 |
| dbo:wikiPageExternalLink | https://www.ncbi.nlm.nih.gov/gene%3Fcmd=Retrieve&dopt=full_report&list_uids=170961 |
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| dbp:caption | Ribbon diagram of a fragment of the membrane-binding domain of ankyrin R. (en) |
| dbp:interpro | IPR002110 (en) |
| dbp:name | Ankyrin repeat domain (en) |
| dbp:pdb | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , (en) |
| dbp:pfam | PF00023 (en) |
| dbp:prosite | PDOC50088 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:smart | SM00248 (en) |
| dbp:symbol | Ank (en) |
| dbp:wikiPageUsesTemplate | dbt:Citation_needed dbt:ELM dbt:Failed_verification dbt:InterPro_content dbt:Interlanguage_link dbt:MeshName dbt:Original_research dbt:Reflist dbt:PDB2 dbt:Protein_tandem_repeats dbt:Pfam_box |
| gold:hypernym | dbr:Motif |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Artifact100021939 yago:Decoration103169390 yago:Design103178782 yago:Motif103789014 yago:Object100002684 yago:PhysicalEntity100001930 dbo:Protein yago:Whole100003553 yago:WikicatProteinStructuralMotifs |
| rdfs:comment | The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. Domains consisting of ankyrin tandem repeats mediate protein–protein interactions and are among the most common structural motifs in known proteins. They appear in bacterial, archaeal, and eukaryotic proteins, but are far more common in eukaryotes. Ankyrin repeat proteins, though absent in most viruses, are common among poxviruses. Most proteins that contain the motif have four to six repeats, although its namesake ankyrin contains 24, and the largest known number of repeats is 34, predicted in a protein expressed by Giardia lamblia. (en) Une répétition ankyrine est une configuration particulière des protéines consistant en 33 résidus d'acides aminés formant deux hélices α séparées par des boucles. Ces domaines sont très répandus, un peu chez les bactéries et les archées, mais surtout chez les eucaryotes. Ils sont absents de la plupart des virus, à l'exception des Poxviridae. Ils sont définis par leur structure et non par leur séquence dans la mesure où aucune séquence particulière n'a été associée aux répétitions ankyrine. La plupart des protéines qui contiennent ce type de structures possèdent de quatre à six répétitions ankyrine, l'ankyrine elle-même en ayant 24, le record étant probablement les 34 répétitions d'une protéine exprimée par Giardia lamblia. (fr) |
| rdfs:label | Ankyrin repeat (en) Répétition ankyrine (fr) |
| owl:sameAs | freebase:Ankyrin repeat yago-res:Ankyrin repeat wikidata:Ankyrin repeat http://bs.dbpedia.org/resource/Ankirinsko_ponavljanje dbpedia-fa:Ankyrin repeat dbpedia-fr:Ankyrin repeat dbpedia-sh:Ankyrin repeat dbpedia-sr:Ankyrin repeat https://global.dbpedia.org/id/2L5iF |
| prov:wasDerivedFrom | wikipedia-en:Ankyrin_repeat?oldid=1062546576&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Ankyrin_R_membrane-binding_domain_1N11.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Ankyrin_repeat |
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| is foaf:primaryTopic of | wikipedia-en:Ankyrin_repeat |
