Ars operon (original) (raw)
In molecular biology, the ars operon is an operon found in several bacterial taxon. It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out of the cell. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite before it is extruded. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance. ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. ArsC forms an active quaternary complex with GSH, arsenate, and
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| dbo:abstract | In molecular biology, the ars operon is an operon found in several bacterial taxon. It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out of the cell. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite before it is extruded. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance. ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. ArsC forms an active quaternary complex with GSH, arsenate, and glutaredoxin 1 (Grx1). The three ligands must be present simultaneously for reduction to occur. (en) |
| dbo:symbol | ArsA_ATPase ArsB ArsC ArsD ArsR |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_1rw1_EBI.jpg?width=300 |
| dbo:wikiPageID | 32148595 (xsd:integer) |
| dbo:wikiPageLength | 8120 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1032087283 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Antimonite dbr:Detoxification dbc:Protein_families dbr:Enzyme dbr:Gene dbr:Genes dbr:Glutathione dbr:Conserved_sequence dbr:Operon dbr:Ligands dbr:Stress_(medicine) dbr:Thioredoxin dbr:Bacteria dbr:Bacterial dbr:Active_site dbr:Cell_(biology) dbr:Transcription_(genetics) dbr:Transcriptional_regulation dbr:Gram-positive dbr:Reductase dbr:Alpha_helix dbr:Cysteine dbr:Base_pair dbr:Glutaredoxin dbr:Protein_complex dbr:Transcription_factor dbr:Protein_folding dbr:Protein dbr:Redox dbr:Residue_(chemistry) dbr:Arsenate dbr:Binding_site dbr:Homology_(biology) dbr:Trans-acting dbr:Dissociation_(chemistry) dbr:Arsenite dbc:Operons dbr:Hydrophobic dbr:Vicinal_(chemistry) dbr:Repressor dbr:Enzyme_substrate dbr:Secondary_structure dbr:Beta-sheet dbr:Homodimer |
| dbp:caption | yffb protein (en) |
| dbp:interpro | IPR000802 (en) IPR006660 (en) IPR010712 (en) IPR018334 (en) |
| dbp:name | Anion-transporting ATPase (en) ArsB (en) ArsC (en) ArsD (en) ArsR (en) |
| dbp:pfam | PF02040 (en) PF02374 (en) PF03960 (en) PF06953 (en) PF09824 (en) |
| dbp:pfamClan | CL0023 (en) CL0123 (en) CL0172 (en) CL0182 (en) |
| dbp:scop | 1 (xsd:integer) 777600.0 a.4.5.5 (en) |
| dbp:symbol | ArsA_ATPase (en) ArsB (en) ArsC (en) ArsD (en) ArsR (en) |
| dbp:tcdb | 3 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist |
| dcterms:subject | dbc:Protein_families dbc:Operons |
| gold:hypernym | dbr:Operon |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 yago:WikicatProteinFamilies |
| rdfs:comment | In molecular biology, the ars operon is an operon found in several bacterial taxon. It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out of the cell. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite before it is extruded. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance. ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. ArsC forms an active quaternary complex with GSH, arsenate, and (en) |
| rdfs:label | Ars operon (en) |
| owl:sameAs | freebase:Ars operon yago-res:Ars operon wikidata:Ars operon https://global.dbpedia.org/id/4SGL4 |
| prov:wasDerivedFrom | wikipedia-en:Ars_operon?oldid=1032087283&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PDB_1rw1_EBI.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Ars_operon |
| is dbo:wikiPageWikiLink of | dbr:ARSD dbr:Biosensor |
| is foaf:primaryTopic of | wikipedia-en:Ars_operon |
