Augmented renal clearance (original) (raw)
In pharmacology, augmented renal clearance (ARC) is a phenomenon where certain critically ill patients may display increased clearance of a medication through the kidneys. In many cases, it is observed as a measured creatinine clearance above that which is expected given the patient's age, gender, and other factors. The phenomenon is most commonly observed in patients with neurologic damage, sepsis, major trauma, or burns.
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| dbo:abstract | In pharmacology, augmented renal clearance (ARC) is a phenomenon where certain critically ill patients may display increased clearance of a medication through the kidneys. In many cases, it is observed as a measured creatinine clearance above that which is expected given the patient's age, gender, and other factors. The phenomenon is most commonly observed in patients with neurologic damage, sepsis, major trauma, or burns. Augmented renal clearance can be caused by increased fluid administration, certain medications, and critical illnesses. It can lead to failure of treatment in people due to a decrease in drug concentrations, increase in clearance, or shorter half life. Many medications require adjustment to account for the changed clearance in people with ARC, notably some antibiotics. (en) |
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| dbo:wikiPageWikiLink | dbr:Aminoglycoside dbr:Antibiotic dbr:Beta-lactam dbr:Vancomycin dbr:Major_trauma dbr:Vasopressors dbr:Clearance_(pharmacology) dbr:Antibiotic_sensitivity_testing dbr:Levetiracetam dbr:Burn dbr:APACHE_III dbr:Aminoglycosides dbr:Norepinephrine dbr:Estimated_glomerular_filtration_rate dbr:Fluoroquinolone dbr:Half-life dbc:Kidney_anatomy dbc:Renal_physiology dbr:Pharmacokinetic dbr:Intensive_care_unit dbr:Sepsis dbr:SOFA_score dbr:Serum_creatinine dbr:Creatinine_clearance dbr:Hematologic_cancer dbr:Neurologic_damage |
| dbp:wikiPageUsesTemplate | dbt:Abbr dbt:Reflist dbt:Short_description dbt:Small |
| dct:subject | dbc:Kidney_anatomy dbc:Renal_physiology |
| rdfs:comment | In pharmacology, augmented renal clearance (ARC) is a phenomenon where certain critically ill patients may display increased clearance of a medication through the kidneys. In many cases, it is observed as a measured creatinine clearance above that which is expected given the patient's age, gender, and other factors. The phenomenon is most commonly observed in patients with neurologic damage, sepsis, major trauma, or burns. (en) |
| rdfs:label | Augmented renal clearance (en) |
| owl:sameAs | wikidata:Augmented renal clearance https://global.dbpedia.org/id/FLtXk |
| prov:wasDerivedFrom | wikipedia-en:Augmented_renal_clearance?oldid=1000156355&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Augmented_renal_clearance |
| is dbo:wikiPageDisambiguates of | dbr:ARC |
| is dbo:wikiPageWikiLink of | dbr:Vancomycin dbr:Clearance_(pharmacology) dbr:ARC |
| is foaf:primaryTopic of | wikipedia-en:Augmented_renal_clearance |