| dbo:abstract |
Blarcamesine (development code ANAVEX2-73) is an experimental drug developed by Anavex Life Sciences. It is in phase IIb/phase III trials for Alzheimer's disease and Rett syndrome, phase IIa trials for Parkinson's disease, phase I trials for epilepsy, and in preclinical trials for amyotrophic lateral sclerosis and stroke. Blarcamesine acts as a muscarinic receptor and a moderate sigma1 receptor agonist. In trials for Alzheimer's disease, Anavex Life Sciences reported that in patients with a fully functional SIGMAR1 gene, which encodes the sigma-1 receptor targeted by blarcamesine, the drug improved cognition as measured by the mini-mental state examination by 14% after 70 weeks of treatment. Competence in activities of daily living was improved by 8% in the same subgroup of patients. Additionally, in trials for Parkinson's disease, episodic memory was significantly improved after 14 weeks of treatment. (en) |
| dbo:casNumber |
195615-83-9 |
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4297224 |
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DB05592 |
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9T210MMZ3F |
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blarcamesine |
| dbo:kegg |
D11383 |
| dbo:pubchem |
9882189 |
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dbr:Bcl-2 dbr:Bcl-2-associated_X_protein dbr:Endoplasmic_reticulum dbr:Epilepsy dbr:Motion_sickness dbr:Short-term_memory dbr:Cytochrome_c dbr:Cytosol dbc:Dimethylamino_compounds dbc:Prodrugs dbr:Competitive_inhibition dbr:Memantine dbr:Mitochondria dbr:Phase_III_trial dbr:Phase_II_trial dbr:Phase_I_trial dbr:Apoptosis dbr:Activities_of_daily_living dbr:Lipid_peroxidation dbr:Long-term_memory dbr:Acetylcholinesterase dbr:Agonist dbr:Amyloid_precursor_protein dbr:Amyotrophic_lateral_sclerosis dbc:Muscarinic_antagonists dbc:Sigma_agonists dbr:Alzheimer's_disease dbr:Parkinson's_disease dbr:Rett_syndrome dbr:Hyperphosphorylation dbr:Donepezil dbr:Hyoscine_hydrobromide dbr:NMDA_receptor dbr:Oxidative_stress dbr:Mini-mental_state_examination dbr:Amyloid-beta dbr:Amyloid-beta_peptide dbr:SIGMAR1 dbr:GSK-3B dbr:Tau_plaque dbr:Sigma1 dbr:Sigma1_receptor dbr:Muscarinic_receptor dbr:Nuclear_factor_kB dbr:Pro-drug dbr:Preclinical_trial dbr:Β-secretase dbr:AF267B dbr:ANAVEX19-144 dbr:ANAVEX_1-41 dbr:Anti-apoptoic dbr:Aβ25-35 |
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Blarcamesine (en) |
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blarcamesine (en) |
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O3CCCC3 (en) |
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BOTHKNZTGGXFEQ-UHFFFAOYSA-N (en) |
| dbp:synonyms |
ANAVEX2-73 (en) |
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owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment |
Blarcamesine (development code ANAVEX2-73) is an experimental drug developed by Anavex Life Sciences. It is in phase IIb/phase III trials for Alzheimer's disease and Rett syndrome, phase IIa trials for Parkinson's disease, phase I trials for epilepsy, and in preclinical trials for amyotrophic lateral sclerosis and stroke. Blarcamesine acts as a muscarinic receptor and a moderate sigma1 receptor agonist. (en) |
| rdfs:label |
Blarcamesine (en) |
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wikidata:Blarcamesine https://global.dbpedia.org/id/2N8fU |
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wikipedia-en:Blarcamesine?oldid=1080257846&ns=0 |
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Blarcamesine (en) |
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