CDC48 N-terminal domain (original) (raw)
In molecular biology, the CDC48 N-terminal domain is a protein domain found in AAA ATPases including cell division protein 48 (CDC48), VCP-like ATPase and N-ethylmaleimide sensitive fusion protein. It is a substrate recognition domain which binds polypeptides, prevents protein aggregation, and catalyses refolding of permissive substrates. It is composed of two equally sized subdomains. The amino-terminal subdomain (CDC48_N) forms a double-psi beta-barrel whose pseudo-twofold symmetry is mirrored by an internal sequence repeat of 42 residues. The carboxy-terminal subdomain (CDC48_2) forms a novel six-stranded beta-clam fold. Together these subdomains form a kidney-shaped structure, in close agreement with results from electron microscopy. CDC48_N is related to numerous proteins including pr
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|---|---|
| dbo:abstract | In molecular biology, the CDC48 N-terminal domain is a protein domain found in AAA ATPases including cell division protein 48 (CDC48), VCP-like ATPase and N-ethylmaleimide sensitive fusion protein. It is a substrate recognition domain which binds polypeptides, prevents protein aggregation, and catalyses refolding of permissive substrates. It is composed of two equally sized subdomains. The amino-terminal subdomain (CDC48_N) forms a double-psi beta-barrel whose pseudo-twofold symmetry is mirrored by an internal sequence repeat of 42 residues. The carboxy-terminal subdomain (CDC48_2) forms a novel six-stranded beta-clam fold. Together these subdomains form a kidney-shaped structure, in close agreement with results from electron microscopy. CDC48_N is related to numerous proteins including prokaryotic transcription factors, metabolic enzymes, the protease cofactors UFD1 and PrlF, and aspartic proteinases. (en) |
| dbo:symbol | CDC48_2 CDC48_N |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_1s3s_EBI.jpg?width=300 |
| dbo:wikiPageID | 32240206 (xsd:integer) |
| dbo:wikiPageLength | 2469 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1032232717 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Prokaryotic dbr:Proteins dbr:Electron_microscopy dbr:Symmetry dbr:Tandem_repeat dbr:Transcription_(genetics) dbr:Protein_domain dbr:Protein_folding dbr:Protease dbr:Residue_(chemistry) dbc:Protein_domains dbr:AAA_proteins dbr:Cofactor_(biochemistry) dbr:Metabolism dbr:Catalysis dbr:Sequence_(biology) dbr:Aspartic_proteinase dbr:Polypeptides dbr:Beta-barrel |
| dbp:caption | crystal structure of aaa atpase p97/vcp nd1 in complex with p47 c (en) amino terminal domain of the n-ethylmaleimide sensitive fusion protein (en) |
| dbp:interpro | IPR003338 (en) IPR004201 (en) |
| dbp:name | CDC48_2 (en) CDC48_N (en) |
| dbp:pfam | PF02359 (en) PF02933 (en) |
| dbp:pfamClan | CL0402 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:symbol | CDC48_2 (en) CDC48_N (en) |
| dbp:wikiPageUsesTemplate | dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist |
| dct:subject | dbc:Protein_domains |
| gold:hypernym | dbr:Domain |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 |
| rdfs:comment | In molecular biology, the CDC48 N-terminal domain is a protein domain found in AAA ATPases including cell division protein 48 (CDC48), VCP-like ATPase and N-ethylmaleimide sensitive fusion protein. It is a substrate recognition domain which binds polypeptides, prevents protein aggregation, and catalyses refolding of permissive substrates. It is composed of two equally sized subdomains. The amino-terminal subdomain (CDC48_N) forms a double-psi beta-barrel whose pseudo-twofold symmetry is mirrored by an internal sequence repeat of 42 residues. The carboxy-terminal subdomain (CDC48_2) forms a novel six-stranded beta-clam fold. Together these subdomains form a kidney-shaped structure, in close agreement with results from electron microscopy. CDC48_N is related to numerous proteins including pr (en) |
| rdfs:label | CDC48 N-terminal domain (en) |
| owl:sameAs | freebase:CDC48 N-terminal domain wikidata:CDC48 N-terminal domain https://global.dbpedia.org/id/4eGeu |
| prov:wasDerivedFrom | wikipedia-en:CDC48_N-terminal_domain?oldid=1032232717&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PDB_1qdn_EBI.jpg wiki-commons:Special:FilePath/PDB_1s3s_EBI.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:CDC48_N-terminal_domain |
| is dbo:wikiPageWikiLink of | dbr:Valosin-containing_protein |
| is foaf:primaryTopic of | wikipedia-en:CDC48_N-terminal_domain |
