AAA proteins (original) (raw)
AAA proteins or ATPases Associated with diverse cellular Activities are a protein family sharing a common conserved module of approximately 230 amino acid residues. This is a large, functionally diverse protein family belonging to the AAA+ protein superfamily of ring-shaped P-loop NTPases, which exert their activity through the energy-dependent remodeling or translocation of macromolecules. AAA proteins couple chemical energy provided by ATP hydrolysis to conformational changes which are transduced into mechanical force exerted on a macromolecular substrate.
| Property | Value |
|---|---|
| dbo:abstract | AAA proteins or ATPases Associated with diverse cellular Activities are a protein family sharing a common conserved module of approximately 230 amino acid residues. This is a large, functionally diverse protein family belonging to the AAA+ protein superfamily of ring-shaped P-loop NTPases, which exert their activity through the energy-dependent remodeling or translocation of macromolecules. AAA proteins couple chemical energy provided by ATP hydrolysis to conformational changes which are transduced into mechanical force exerted on a macromolecular substrate. AAA proteins are functionally and organizationally diverse, and vary in activity, stability, and mechanism. Members of the AAA family are found in all organisms and they are essential for many cellular functions. They are involved in processes such as DNA replication, protein degradation, membrane fusion, microtubule severing, peroxisome biogenesis, signal transduction and the regulation of gene expression. (en) Les protéines AAA ou ATPases Associées à diverses Activités cellulaires constituent une famille de protéines qui partagent un domaine conservé commun d'environ 230 acides aminés de long. Il s'agit d'une grande famille protéique fonctionnellement diverse, appartenant à la superfamille protéique AAA+ des NTPases en motifs de Walker en forme d'anneaux, qui exercent leur activité par la reconstruction (consommant de l'énergie) ou la translocation de macromolécules. Les protéines AAA couplent l'énergie chimique fournie par l'hydrolyse de l'ATP à des changements de conformation qui sont transduits en une force mécanique exercée sur un substrat macromoléculaire. Les protéines AAA possèdent diverses fonctions et organisations, et varient dans leur activité, leur stabilité et leur mécanisme. On retrouve des membres de la famille AAA chez tous les organismes et ils sont essentiels pour de nombreuses fonctions cellulaires. Ils sont impliqués dans des processus comme la réplication de l'ADN, la dégradation des protéines, la fusion membranaire, la séparation des microtubules, la biogénèse du peroxysome, la transduction du signal et la régulation de l'expression des gènes. (fr) As proteínas AAA ou ATPases associadas a diversas atividades celulares são uma família de proteínas que compartilha um módulo conservado comum de aproximadamente 230 resíduos de aminoácidos. Elas estão envolvidos em processos como replicação de DNA, degradação de proteínas, fusão de membranas, separação de microtúbulos, biogênese de peroxissomos, transdução de sinal e regulação da expressão gênica. As proteínas AAA são funcional e organizacionalmente diversas e variam em atividade, estabilidade e mecanismo. Os membros da família AAA são encontrados em todos os organismos e são essenciais para muitas funções celulares. Esta é uma família de proteínas grande e funcionalmente diversa, pertencente à superfamília de proteínas AAA + das NTPases de em forma de anel, que exercem sua atividade através da remodelação ou translocação dependente de energia de macromoléculas. As proteínas AAA acoplam a energia química fornecida pela hidrólise de ATP a alterações conformacionais que são transduzidas em força mecânica exercida em um substrato macromolecular. (pt) |
| dbo:symbol | AAA |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_1nsf_EBI.jpg?width=300 |
| dbo:wikiPageID | 1091831 (xsd:integer) |
| dbo:wikiPageLength | 12081 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1079570428 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Rossmann_fold dbr:N-ethylmaleimide_sensitive_fusion_protein dbr:MDN1 dbr:ORC1 dbr:SPAST dbr:SPG7 dbr:DNA_replication dbr:CDC6 dbr:Dynein dbr:ESCRT dbr:KATNA1 dbr:PSMC5 dbc:Protein_families dbr:Nucleophile dbr:RFC1 dbr:VPS4A dbr:PEX6 dbr:RFC5 dbr:Conformational_change dbr:LONP1 dbr:RFC2 dbr:Torsin_A dbr:Proteolytic dbr:TOR3A dbr:Protein_superfamily dbr:PSMC2 dbr:Amino_acid dbr:E._coli dbr:Eukaryote dbr:Protein_domain dbr:Protein_family dbc:Protein_domains dbr:AFG3L2 dbr:RUVBL2 dbr:ATP-dependent_Clp_protease_proteolytic_subunit dbr:ATP_hydrolysis dbc:Single-pass_transmembrane_proteins dbr:YME1L1 dbr:VPS4B dbr:BCS1L dbr:Clade dbr:Microtubules dbr:Chaperone_(protein) dbr:CHTF18 dbr:Microtubule dbr:Valosin-containing_protein dbr:PSMC1 dbr:SPATA5 dbr:TRIP13 dbr:NVL_(gene) dbr:ORC4 dbr:TOR2A dbr:Multivesicular_bodies dbr:WRNIP1 dbr:Motor_protein dbr:PSMC4 dbr:RFC3 dbr:PEX1 dbr:PSMC6 dbr:RFC4 dbr:Walker_motifs dbr:PSMC3 dbr:Protein_aggregates dbr:Protein_degradation dbr:Macromolecular dbr:P-loop dbr:Membrane_fusion dbr:RUVBL1 dbr:ERAD dbr:AK6 dbr:ATAD1 dbr:ATAD2 dbr:ATAD2B dbr:ATAD3A dbr:ATAD3B dbr:ATAD3C dbr:ATAD5 dbr:CLBP dbr:CLPX dbr:FIGN dbr:FIGNL1 dbr:FIGNL2 dbr:IQCA1 dbr:KATNAL1 dbr:KATNAL2 dbr:LONP2 dbr:SPATA5L1 dbr:TOR1B dbr:TOR4A |
| dbp:caption | Structure of N-ethylmaleimide-sensitive factor. (en) |
| dbp:cdd | cd00009 (en) |
| dbp:interpro | IPR003959 (en) |
| dbp:membranomeSuperfamily | 74 (xsd:integer) |
| dbp:name | ATPases associated with diverse cellular activities (en) |
| dbp:pfam | PF00004 (en) |
| dbp:pfamClan | CL0023 (en) |
| dbp:prosite | PDOC00572 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:symbol | AAA (en) |
| dbp:wikiPageUsesTemplate | dbt:Cite_journal dbt:Other_uses dbt:Reflist dbt:See_also dbt:Short_description dbt:Pfam_box |
| dct:subject | dbc:Protein_families dbc:Protein_domains dbc:Single-pass_transmembrane_proteins |
| gold:hypernym | dbr:Abbreviation |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:WikicatSingle-passTransmembraneProteins yago:Abstraction100002137 yago:Attribute100024264 yago:Chemical114806838 yago:Compound114818238 yago:Environment113934596 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Organisation dbo:Protein yago:Situation113927383 yago:Sphere114514039 yago:State100024720 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteinDomains yago:WikicatProteins |
| rdfs:comment | AAA proteins or ATPases Associated with diverse cellular Activities are a protein family sharing a common conserved module of approximately 230 amino acid residues. This is a large, functionally diverse protein family belonging to the AAA+ protein superfamily of ring-shaped P-loop NTPases, which exert their activity through the energy-dependent remodeling or translocation of macromolecules. AAA proteins couple chemical energy provided by ATP hydrolysis to conformational changes which are transduced into mechanical force exerted on a macromolecular substrate. (en) Les protéines AAA ou ATPases Associées à diverses Activités cellulaires constituent une famille de protéines qui partagent un domaine conservé commun d'environ 230 acides aminés de long. Il s'agit d'une grande famille protéique fonctionnellement diverse, appartenant à la superfamille protéique AAA+ des NTPases en motifs de Walker en forme d'anneaux, qui exercent leur activité par la reconstruction (consommant de l'énergie) ou la translocation de macromolécules. (fr) As proteínas AAA ou ATPases associadas a diversas atividades celulares são uma família de proteínas que compartilha um módulo conservado comum de aproximadamente 230 resíduos de aminoácidos. Elas estão envolvidos em processos como replicação de DNA, degradação de proteínas, fusão de membranas, separação de microtúbulos, biogênese de peroxissomos, transdução de sinal e regulação da expressão gênica. As proteínas AAA acoplam a energia química fornecida pela hidrólise de ATP a alterações conformacionais que são transduzidas em força mecânica exercida em um substrato macromolecular. (pt) |
| rdfs:label | AAA proteins (en) Protéines AAA (fr) Proteínas AAA (pt) |
| rdfs:seeAlso | dbr:HUGO_Gene_Nomenclature_Committee |
| owl:sameAs | freebase:AAA proteins yago-res:AAA proteins wikidata:AAA proteins dbpedia-fa:AAA proteins dbpedia-fr:AAA proteins dbpedia-gl:AAA proteins dbpedia-mk:AAA proteins dbpedia-pt:AAA proteins https://global.dbpedia.org/id/4KA9T |
| prov:wasDerivedFrom | wikipedia-en:AAA_proteins?oldid=1079570428&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PDB_1nsf_EBI.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:AAA_proteins |
| is dbo:wikiPageDisambiguates of | dbr:AAA |
| is dbo:wikiPageRedirects of | dbr:AAA-ATPase dbr:AAA_ATPase dbr:AAA+ dbr:AAA_protein |
| is dbo:wikiPageWikiLink of | dbr:Proteasome dbr:List_of_biophysically_important_macromolecular_crystal_structures dbr:N-ethylmaleimide_sensitive_fusion_protein dbr:Meiotic_recombination_checkpoint dbr:Arginine_finger dbr:DNA_re-replication dbr:Dynein dbr:ESCRT dbr:KATNA1 dbr:Origin_of_replication dbr:LONP1 dbr:Torsin_A dbr:ClpX dbr:FtsK dbr:Acyldepsipeptide_antibiotics dbr:Cdc6 dbr:AAA-ATPase dbr:ATP-binding_cassette_transporter dbr:AAA dbr:AAA_ATPase dbr:ATP-dependent_Clp_protease_proteolytic_subunit dbr:ATPase dbr:ATPase_Domain_3B dbr:YME1L1 dbr:CDC48_N-terminal_domain dbr:CLPB dbr:Minichromosome_maintenance dbr:SNARE_(protein) dbr:POLDIP2 dbr:TRIP13 dbr:N-end_rule dbr:Tania_A._Baker dbr:Spastin dbr:Reptin dbr:PEX1 dbr:Walker_motifs dbr:WD_Repeat_and_Coiled_Coil_Containing_Protein dbr:AAA+ dbr:AAA_protein |
| is foaf:primaryTopic of | wikipedia-en:AAA_proteins |
