DUT (gene) (original) (raw)
DUTP pyrophosphatase, also known as DUT, is an enzyme which in humans is encoded by the DUT gene on chromosome 15. This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotrimeric enzyme that hydrolyzes to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to di
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| dbo:abstract | DUTP pyrophosphatase, also known as DUT, is an enzyme which in humans is encoded by the DUT gene on chromosome 15. This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotrimeric enzyme that hydrolyzes to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. (en) DUT (англ. Deoxyuridine triphosphatase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 15-ї хромосоми. Довжина поліпептидного ланцюга білка становить 252 амінокислот, а молекулярна маса — 26 563. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до гідролаз, фосфопротеїнів. Задіяний у таких біологічних процесах, як метаболізм нуклеотидів, альтернативний сплайсинг. Білок має сайт для зв'язування з іоном магнію. Локалізований у ядрі, мітохондрії. (uk) |
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| dbo:wikiPageWikiLink | dbr:Pyrophosphate dbr:Nucleotide dbr:Sp1_transcription_factor dbr:C-terminal dbr:Breast_cancer dbr:Repair dbr:Cyclin-dependent_kinase dbr:Cytoplasm dbr:DNA dbr:DNA_repair dbr:DNA_replication dbr:Uracil dbr:E2F dbr:P53 dbr:Pseudogene dbr:Northern_blot dbr:MRNA dbr:Gastrointestinal_cancer dbr:Genome dbr:Enzyme dbr:Gene dbr:Mitochondrion dbr:NF-κB dbr:Substrate_(biochemistry) dbr:Thymidylate_synthase dbr:Active_site dbr:Thymine dbr:Catalytic dbr:Cytotoxic dbr:DUTPase dbr:Head_and_neck_cancer dbr:Karyopherin dbr:Amino_acid dbr:Alternative_splicing dbr:Exons dbr:Base_pair dbr:Cell_cycle dbr:Cell_death dbr:Cell_nucleus dbr:Glycosylase dbr:Isoelectric_point dbr:Isomerization dbr:Isoform dbr:Promoter_(genetics) dbr:Hepatocellular_carcinoma dbr:Biomarker dbr:Biosynthesis dbr:Homotrimer dbr:Hydrolyze dbr:DTTP dbr:DUMP dbr:Metal_ion dbr:Metabolism dbr:Serine dbr:S_phase dbr:Divalent dbr:Nuclear_localization_signal dbr:Subcellular_localization dbr:Β-strand dbr:Methylate dbr:Phosphorylate dbr:Targeting_sequence dbr:Chemotherapeutic dbr:Mg2+ dbr:5-fluorouracil dbr:N-terminal dbr:Prognostic dbr:Pyrophosphoralysis dbr:Thymidylate dbr:Post-translational dbr:Excision_repair dbr:Neoplastic_disease dbr:DUTP |
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| rdfs:comment | DUTP pyrophosphatase, also known as DUT, is an enzyme which in humans is encoded by the DUT gene on chromosome 15. This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotrimeric enzyme that hydrolyzes to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to di (en) DUT (англ. Deoxyuridine triphosphatase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 15-ї хромосоми. Довжина поліпептидного ланцюга білка становить 252 амінокислот, а молекулярна маса — 26 563. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | DUT (gene) (en) DUT (uk) |
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| is foaf:primaryTopic of | wikipedia-en:DUT_(gene) |