| dbo:abstract |
In the field of enzymology, a dimethylargininase, also known as a dimethylarginine dimethylaminohydrolase (DDAH), is an enzyme that catalyzes the chemical reaction: N-omega,N-omega'-methyl-L-arginine + H2O dimethylamine + L-citrulline Thus, the two substrates of this enzyme are N-omega,N-omega'-methyl-L-arginine and H2O, whereas its two products are dimethylamine and L-citrulline. (en) La diméthylargininase est une hydrolase qui catalyse la réaction : Nω,Nω-diméthyl-L-arginine + H2O diméthylamine + L-citrulline. Cette enzyme agit également sur la Nω-méthyl-L-arginine. Elle a pour effet de limiter l'accumulation de mono- et diméthylarginine résultant de la dégradation des protéines méthylées. Ceci est important car les méthylarginines sont notamment des inhibiteurs de l'oxyde nitrique synthase, et donc bloquent la production de monoxyde d'azote, d'où une vasoconstriction. (fr) |
| dbo:ecNumber |
3.5.3.18 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/DDAH1.png?width=300 |
| dbo:wikiPageID |
14502577 (xsd:integer) |
| dbo:wikiPageLength |
10843 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1081536643 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Mouse dbr:Blood_plasma dbr:Blood_pressure dbr:Homocysteine dbr:Inflammation dbr:Insulin_resistance dbr:Enzymology dbc:Enzymes_of_known_structure dbr:Chemical_reaction dbr:Enzyme dbr:Antioxidants dbr:Mammal dbr:Functional_group dbr:Substrate_(biochemistry) dbr:Systole_(medicine) dbr:Transgenic dbr:Active_site dbr:Cell_(biology) dbc:EC_3.5.3 dbr:Cytokines dbr:Angiogenesis dbr:Nitrate dbr:Nitric_oxide dbr:Nitric_oxide_synthase dbr:Cardiovascular_disease dbr:Endothelial dbr:Product_(chemistry) dbr:Regeneration_(biology) dbr:Ribbon_diagram dbr:Hypercholesterolemia dbr:Hyperglycemia dbr:Hyperhomocysteinemia dbr:Asymmetric_dimethylarginine dbr:Sulfhydryl dbr:Diabetes_mellitus dbr:Dimethylamine dbr:Disulfide dbr:Metabolism dbr:Methylarginine dbr:Negative_feedback dbr:Catalysis dbr:Urine dbr:Water dbr:Oxidation dbr:Protein_detoxification dbr:Vasoconstriction dbr:Oxidative_stress dbr:Enzyme_inhibition dbr:L-citrulline dbr:LDL-cholesterol dbr:NG-monomethyl-L-arginine dbr:Infectious_agents |
| dbp:arm |
p (en) |
| dbp:band |
21 (xsd:integer) 22 (xsd:integer) |
| dbp:caption |
Ribbon diagram of human DDAH1. (en) |
| dbp:casNumber |
123644 (xsd:integer) |
| dbp:chromosome |
1 (xsd:integer) 6 (xsd:integer) |
| dbp:ecNumber |
3.500000 (xsd:double) |
| dbp:ecnumber |
3.500000 (xsd:double) |
| dbp:entrezgene |
23564 (xsd:integer) 23576 (xsd:integer) |
| dbp:goCode |
16403 (xsd:integer) |
| dbp:hgncid |
2715 (xsd:integer) 2716 (xsd:integer) |
| dbp:iubmbEcNumber |
3 (xsd:integer) |
| dbp:name |
dimethylargininase (en) dimethylarginine dimethylaminohydrolase 1 (en) dimethylarginine dimethylaminohydrolase 2 (en) |
| dbp:omim |
604743 (xsd:integer) 604744 (xsd:integer) |
| dbp:refseq |
NM_012137 (en) NM_013974 (en) |
| dbp:symbol |
DDAH1 (en) DDAH2 (en) |
| dbp:uniprot |
O94760 (en) O95865 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Carbon-nitrogen_non-peptide_hydrolases dbt:Cite_journal dbt:Enzyme dbt:Enzymes dbt:MeshName dbt:Portal_bar dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:Infobox_protein |
| dcterms:subject |
dbc:Enzymes_of_known_structure dbc:EC_3.5.3 |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatEnzymesOfKnownStructure umbel-rc:ProteinMolecule |
| rdfs:comment |
In the field of enzymology, a dimethylargininase, also known as a dimethylarginine dimethylaminohydrolase (DDAH), is an enzyme that catalyzes the chemical reaction: N-omega,N-omega'-methyl-L-arginine + H2O dimethylamine + L-citrulline Thus, the two substrates of this enzyme are N-omega,N-omega'-methyl-L-arginine and H2O, whereas its two products are dimethylamine and L-citrulline. (en) La diméthylargininase est une hydrolase qui catalyse la réaction : Nω,Nω-diméthyl-L-arginine + H2O diméthylamine + L-citrulline. Cette enzyme agit également sur la Nω-méthyl-L-arginine. Elle a pour effet de limiter l'accumulation de mono- et diméthylarginine résultant de la dégradation des protéines méthylées. Ceci est important car les méthylarginines sont notamment des inhibiteurs de l'oxyde nitrique synthase, et donc bloquent la production de monoxyde d'azote, d'où une vasoconstriction. (fr) |
| rdfs:label |
Dimethylargininase (en) Diméthylargininase (fr) |
| owl:sameAs |
freebase:Dimethylargininase yago-res:Dimethylargininase wikidata:Dimethylargininase dbpedia-fr:Dimethylargininase dbpedia-sh:Dimethylargininase dbpedia-sr:Dimethylargininase https://global.dbpedia.org/id/4inKQ |
| prov:wasDerivedFrom |
wikipedia-en:Dimethylargininase?oldid=1081536643&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/DDAH1.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Dimethylargininase |
| foaf:name |
dimethylargininase (en) |
| is dbo:wikiPageRedirects of |
dbr:Nomega,Nomega'-dimethyl-L-arginine_dimethylamidohydrolase dbr:DDAH dbr:EC_3.5.3.18 dbr:Dimethylarginine_dimethylaminohydrolase |
| is dbo:wikiPageWikiLink of |
dbr:Proton-pump_inhibitor dbr:Nomega,Nomega'-dimethyl-L-arginine_dimethylamidohydrolase dbr:List_of_EC_numbers_(EC_3) dbr:DDAH dbr:EC_3.5.3.18 dbr:Dimethylarginine_dimethylaminohydrolase |
| is foaf:primaryTopic of |
wikipedia-en:Dimethylargininase |
