| dbo:abstract |
In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane. FERM domains are found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. The FERM domain is located at the N terminus in the majority of proteins in which it is found. (en) |
| dbo:symbol |
FERM_C FERM_M FERM_N |
| dbo:thumbnail |
wiki-commons:Special:FilePath/PDB_1h4r_EBI.jpg?width=300 |
| dbo:wikiPageID |
32752776 (xsd:integer) |
| dbo:wikiPageLength |
7061 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1032063395 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Caenorhabditis_elegans dbr:Protein_tyrosine_phosphatase dbr:Proteins dbr:Ezrin dbr:F-actin dbr:Merlin_(protein) dbr:Molecule dbr:Mutation dbr:Nucleotide dbr:Plasma_membrane dbr:Hormones dbr:Cytokine dbr:Cytoplasm dbr:Cytoskeleton dbr:Deafness dbr:Integral_membrane_protein dbr:Chemotaxis dbr:Enzymes dbr:Myosin dbr:Conserved_sequence dbr:Crystal_structure dbr:Protein_domains dbr:Lymphocytes dbr:Protein_Tyrosine_Kinase dbr:Signalling_pathway dbr:Actin dbr:Adherens_junction dbr:Tyrosine dbr:GTPase dbr:Cytoplasmic dbr:Helix dbr:ERM_protein_family dbr:Cell_membrane dbr:Kinase dbr:Protein_domain dbr:Focal_adhesion_kinase dbr:Protein dbr:Radixin dbr:Receptor_(biochemistry) dbr:Residue_(chemistry) dbc:Protein_domains dbr:Guanine dbr:Talin_(protein) dbr:EPB41 dbr:PTPN14 dbr:Binding_site dbr:Slime_mould dbr:Cytoskeletal dbr:Molecular_binding dbr:Moesin dbr:Sequence_(biology) dbr:Ubiquitin dbr:Congenital dbr:PTPN3 dbr:PTPN4 dbr:Spectrin dbr:Microvilli dbr:Integrins dbr:PH_domain dbr:Secondary_structure dbr:Cell_motility dbr:Actin_filaments dbr:Myosin_VIIA dbr:Erythrocyte dbr:Band_4.1 dbr:N_terminus dbr:TYK2 |
| dbp:caption |
crystal structure of the ferm domain of merlin, the neurofibromatosis 2 tumor suppressor protein. (en) crystal structure of the radixin ferm domain complexed with the nep cytoplasmic tail (en) crystal structure of the protein 4.1r membrane binding domain (en) |
| dbp:cdd |
cd00836 (en) cd14473 (en) |
| dbp:interpro |
IPR018979 (en) IPR018980 (en) IPR019748 (en) |
| dbp:membranomeSuperfamily |
161 (xsd:integer) |
| dbp:name |
FERM C-terminal PH-like domain (en) FERM N-terminal domain (en) FERM central domain (en) |
| dbp:opmFamily |
49 (xsd:integer) |
| dbp:opmProtein |
1 (xsd:integer) |
| dbp:pfam |
PF00373 (en) PF09379 (en) PF09380 (en) |
| dbp:pfamClan |
CL0072 (en) CL0266 (en) |
| dbp:scop |
1 (xsd:integer) |
| dbp:symbol |
FERM_C (en) FERM_M (en) FERM_N (en) |
| dbp:wikiPageUsesTemplate |
dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist |
| dcterms:subject |
dbc:Protein_domains |
| gold:hypernym |
dbr:Module |
| rdf:type |
owl:Thing dbo:Software dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 |
| rdfs:comment |
In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane. FERM domains are found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. The FERM domain is located at the N terminus in the majority of proteins in which it is found. (en) |
| rdfs:label |
FERM domain (en) |
| owl:sameAs |
freebase:FERM domain wikidata:FERM domain dbpedia-fa:FERM domain https://global.dbpedia.org/id/2Kz7j |
| prov:wasDerivedFrom |
wikipedia-en:FERM_domain?oldid=1032063395&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/PDB_1gg3_EBI.jpg wiki-commons:Special:FilePath/PDB_1h4r_EBI.jpg wiki-commons:Special:FilePath/PDB_2yvc_EBI.jpg |
| foaf:isPrimaryTopicOf |
wikipedia-en:FERM_domain |
| is dbo:wikiPageDisambiguates of |
dbr:Ferm |
| is dbo:wikiPageWikiLink of |
dbr:Ezrin dbr:FERMT3 dbr:Merlin_(protein) dbr:JAK-STAT_signaling_pathway dbr:Myosin dbr:Janus_kinase dbr:Janus_kinase_3 dbr:ERM_protein_family dbr:Hippo_signaling_pathway dbr:Talin_(protein) dbr:Ferm dbr:FAM107B dbr:MYO10 dbr:PIP5K1C dbr:PTK2 |
| is foaf:primaryTopic of |
wikipedia-en:FERM_domain |
