Florbetaben (18F) (original) (raw)

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dbo:abstract Florbetaben, a fluorine-18 (18F)-labeled stilbene derivative (formerly known as BAY-949172), trade name NeuraCeq, is a diagnostic radiotracer developed for routine clinical application to visualize β-amyloid plaques in the brain. It is indicated for Positron Emission Tomography (PET) imaging of β-amyloid neuritic plaque density in the brains of adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) and other causes of cognitive impairment. β-amyloid is a key neuropathological hallmark of AD, so markers of β-amyloid plaque accumulation in the brain are useful in distinguishing AD from other causes of dementia. The tracer successfully completed a global multicenter phase 0–III development program and obtained approval in Europe, US and South Korea in 2014. (en) Флорбетабен (18F) — радиофармацевтический препарат для диагностики болезни Альцгеймера. Одобрен для применения: США (2014). (ru)
dbo:alternativeName Neuraceq (en)
dbo:casNumber 902143-01-5
dbo:chEBI 79033
dbo:fdaUniiCode TLA7312TOI
dbo:pubchem 11501341
dbo:thumbnail wiki-commons:Special:FilePath/Florbetaben_F18.svg?width=300
dbo:wikiPageExternalLink http://neuraceq.com/ http://www.piramal.com/imaging/ https://link.springer.com/article/10.1007%2Fs40263-015-0258-7 https://link.springer.com/article/10.1007%2Fs40336-015-0102-6
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dbp:atcPrefix V09 (en)
dbp:atcSuffix AX06 (en)
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dbp:casNumber 902143 (xsd:integer)
dbp:chebi 79033 (xsd:integer)
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dbp:dailymedid Florbetaben (en)
dbp:drugName Florbetaben (en)
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dbp:licenceUs Florbetaben (en)
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dbp:pregnancyUs C (en)
dbp:pubchem 11501341 (xsd:integer)
dbp:routesOfAdministration dbr:Intravenous
dbp:smiles CNC1=CC=C/C=C/C2=CC=COCCOCCOCC[18F] (en)
dbp:stdinchi 1 (xsd:integer)
dbp:stdinchikey NCWZOASIUQVOFA-FWZJPQCDSA-N (en)
dbp:synonyms BAY-949172 (en)
dbp:tradename Neuraceq (en)
dbp:unii TLA7312TOI (en)
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rdfs:comment Флорбетабен (18F) — радиофармацевтический препарат для диагностики болезни Альцгеймера. Одобрен для применения: США (2014). (ru) Florbetaben, a fluorine-18 (18F)-labeled stilbene derivative (formerly known as BAY-949172), trade name NeuraCeq, is a diagnostic radiotracer developed for routine clinical application to visualize β-amyloid plaques in the brain. It is indicated for Positron Emission Tomography (PET) imaging of β-amyloid neuritic plaque density in the brains of adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) and other causes of cognitive impairment. β-amyloid is a key neuropathological hallmark of AD, so markers of β-amyloid plaque accumulation in the brain are useful in distinguishing AD from other causes of dementia. The tracer successfully completed a global multicenter phase 0–III development program and obtained approval in Europe, US and South Korea in 20 (en)
rdfs:label Florbetaben (18F) (en) Флорбетабен (ru)
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