Galanin receptor (original) (raw)
The galanin receptor is a G protein-coupled receptor, or metabotropic receptor which binds galanin. Galanin receptors can be found throughout the peripheral and central nervous systems and the endocrine system. So far three subtypes are known to exist: GAL-R1, GAL-R2, and GAL-R3. The specific function of each subtype remains to be fully elucidated, although as of 2009 great progress is currently being made in this respect with the generation of receptor subtype-specific knockout mice, and the first selective ligands for galanin receptor subtypes. Selective galanin agonists are anticonvulsant, while antagonists produce antidepressant and anxiolytic effects in animals, so either agonist or antagonist ligands for the galanin receptors may be potentially therapeutic compounds in humans.
| Property | Value |
|---|---|
| dbo:abstract | The galanin receptor is a G protein-coupled receptor, or metabotropic receptor which binds galanin. Galanin receptors can be found throughout the peripheral and central nervous systems and the endocrine system. So far three subtypes are known to exist: GAL-R1, GAL-R2, and GAL-R3. The specific function of each subtype remains to be fully elucidated, although as of 2009 great progress is currently being made in this respect with the generation of receptor subtype-specific knockout mice, and the first selective ligands for galanin receptor subtypes. Selective galanin agonists are anticonvulsant, while antagonists produce antidepressant and anxiolytic effects in animals, so either agonist or antagonist ligands for the galanin receptors may be potentially therapeutic compounds in humans. (en) |
| dbo:arm | q |
| dbo:band | 23 12.2 25.3 |
| dbo:chromosome | 22 17 18 |
| dbo:entrezgene | 8484 2587 8811 |
| dbo:hgncid | 4134 4132 4133 |
| dbo:locusSupplementaryData | -13.1 |
| dbo:omim | 600377 (xsd:integer) 603691 (xsd:integer) 603692 (xsd:integer) |
| dbo:refseq | NM_001480 NM_003614 NM_003857 |
| dbo:symbol | GALNR1, GALNR GALR1 GALR2 GALR3 |
| dbo:uniprot | O43603 O60755 P47211 |
| dbo:wikiPageExternalLink | http://www.iuphar-db.org/GPCR/ChapterMenuForward%3FchapterID=1333 |
| dbo:wikiPageID | 9492012 (xsd:integer) |
| dbo:wikiPageLength | 13052 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1109667559 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Metabotropic_receptor dbr:Allosteric_modulator dbr:Anticonvulsant dbr:Galanin dbr:Galmic dbr:Galnon dbr:Antidepressant dbr:Anxiolytic dbr:G_protein-coupled_receptor dbr:Galanin-like_peptide dbr:Galanin_receptor_1 dbr:Galanin_receptor_2 dbr:Galanin_receptor_3 dbc:G_protein-coupled_receptors dbr:SCH-202,596 dbr:SNAP-37889 |
| dbp:altsymbols | GALNR1, GALNR (en) |
| dbp:arm | q (en) |
| dbp:band | 12.200000 (xsd:double) 23 (xsd:integer) 25.300000 (xsd:double) |
| dbp:chromosome | 17 (xsd:integer) 18 (xsd:integer) 22 (xsd:integer) |
| dbp:entrezgene | 2587 (xsd:integer) 8484 (xsd:integer) 8811 (xsd:integer) |
| dbp:hgncid | 4132 (xsd:integer) 4133 (xsd:integer) 4134 (xsd:integer) |
| dbp:locussupplementarydata | -13.100000 (xsd:double) |
| dbp:name | dbr:Galanin_receptor_1 dbr:Galanin_receptor_2 dbr:Galanin_receptor_3 |
| dbp:omim | 600377 (xsd:integer) 603691 (xsd:integer) 603692 (xsd:integer) |
| dbp:refseq | NM_001480 (en) NM_003614 (en) NM_003857 (en) |
| dbp:symbol | GALR1 (en) GALR2 (en) GALR3 (en) |
| dbp:uniprot | O43603 (en) O60755 (en) P47211 (en) |
| dbp:wikiPageUsesTemplate | dbt:G_protein-coupled_receptors dbt:Cite_web dbt:MeshName dbt:Reflist dbt:Infobox_protein dbt:Neuropeptide_receptors |
| dct:subject | dbc:G_protein-coupled_receptors |
| gold:hypernym | dbr:Receptor |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:BodyPart105220461 yago:Part109385911 yago:PhysicalEntity100001930 yago:Receptor105608868 yago:WikicatGProteinCoupledReceptors dbo:Protein yago:Structure105225602 yago:Thing100002452 umbel-rc:ProteinMolecule |
| rdfs:comment | The galanin receptor is a G protein-coupled receptor, or metabotropic receptor which binds galanin. Galanin receptors can be found throughout the peripheral and central nervous systems and the endocrine system. So far three subtypes are known to exist: GAL-R1, GAL-R2, and GAL-R3. The specific function of each subtype remains to be fully elucidated, although as of 2009 great progress is currently being made in this respect with the generation of receptor subtype-specific knockout mice, and the first selective ligands for galanin receptor subtypes. Selective galanin agonists are anticonvulsant, while antagonists produce antidepressant and anxiolytic effects in animals, so either agonist or antagonist ligands for the galanin receptors may be potentially therapeutic compounds in humans. (en) |
| rdfs:label | Galanin receptor (en) |
| owl:sameAs | freebase:Galanin receptor wikidata:Galanin receptor dbpedia-sh:Galanin receptor dbpedia-sr:Galanin receptor https://global.dbpedia.org/id/4jQAf |
| prov:wasDerivedFrom | wikipedia-en:Galanin_receptor?oldid=1109667559&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Galanin_receptor |
| foaf:name | galanin receptor 1 (en) galanin receptor 2 (en) galanin receptor 3 (en) |
| is dbo:wikiPageRedirects of | dbr:Receptors,_galanin |
| is dbo:wikiPageWikiLink of | dbr:Rhodopsin-like_receptors dbr:Galanin dbr:Galmic dbr:Galnon dbr:G_protein-coupled_inwardly-rectifying_potassium_channel dbr:Galanin_receptor_1 dbr:Galanin_receptor_2 dbr:Galanin_receptor_3 dbr:List_of_signaling_peptide/protein_receptor_modulators dbr:Receptors,_galanin |
| is foaf:primaryTopic of | wikipedia-en:Galanin_receptor |