G protein-coupled inwardly-rectifying potassium channel (original) (raw)
Le courant potassique rectifiant activé par les protéines G ou GIRK, pour l'anglais G-protein activated Inwardly Rectifying K+ current, appartient à la famille des courants potassiques rectifiant. Le terme rectifiant est ici utilisé en référence au composant électronique, le redresseur ((en) rectifier), qui n'est conducteur que pour une polarité. La séparation du complexe trimèrique des protéines G active ce courant via les sous-unités β (bêta) et γ (gamma). Ce courant entraîne une hyperpolarisation du potentiel de repos qui inhibe le neurone.
| Property | Value |
|---|---|
| dbo:abstract | The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of lipid-gated inward-rectifier potassium ion channels which are activated (opened) by the signaling lipid PIP2 and a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits (Gβγ) from inactive heterotrimeric G protein complexes (Gαβγ). Finally, the Gβγ dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions, resulting in hyperpolarization of the cell membrane. G protein-coupled inwardly-rectifying potassium channels are a type of G protein-gated ion channels because of this direct interaction of G protein subunits with GIRK channels. The activation likely works by increasing the affinity of the channel for PIP2. In high concentration PIP2 activates the channel absent G-protein, but G-protein does not activate the channel absent PIP2. GIRK1 to GIRK3 are distributed broadly in the central nervous system, where their distributions overlap. GIRK4, instead, is found primarily in the heart. (en) Le courant potassique rectifiant activé par les protéines G ou GIRK, pour l'anglais G-protein activated Inwardly Rectifying K+ current, appartient à la famille des courants potassiques rectifiant. Le terme rectifiant est ici utilisé en référence au composant électronique, le redresseur ((en) rectifier), qui n'est conducteur que pour une polarité. La séparation du complexe trimèrique des protéines G active ce courant via les sous-unités β (bêta) et γ (gamma). Ce courant entraîne une hyperpolarisation du potentiel de repos qui inhibe le neurone. (fr) G-белок-связанные калиевые каналы внутреннего выпрямления (так называемые GIRK) — это подсемейство калиевых каналов внутреннего выпрямления, которые активируются (открываются) вследствие передачи сигнала с активированного вследствие связывания лиганда-агониста G-белок-связанного рецептора, вследствие чего от G-белка отсоединяется димер из βγ-субъединиц, который и активирует GIRK. Каналы подтипа GIRK1, GIRK2 и GIRK3 широко представлены в ЦНС, где их области распределения частично перекрываются. Каналы подтипа GIRK4, однако, в основном находятся в сердце. (ru) |
| dbo:arm | q |
| dbo:band | 24 24.1 22.1 23.2 |
| dbo:chromosome | 2 1 11 21 |
| dbo:entrezgene | 3762 3763 3765 3760 |
| dbo:hgncid | 6270 6267 6264 6266 |
| dbo:omim | 600734 (xsd:integer) 600877 (xsd:integer) 600932 (xsd:integer) 601534 (xsd:integer) |
| dbo:refseq | NM_000890 NM_002239 NM_002240 NM_004983 |
| dbo:symbol | KCNJ3 KCNJ5 KCNJ6 KCNJ7, Kir3.2, GIRK2, KATP2, BIR1, hiGIRK2 KCNJ9 Kir3.1, GIRK1, KGA Kir3.3, GIRK3 Kir3.4, CIR, KATP1, GIRK4 |
| dbo:uniprot | P48051 P48544 P48549 Q92806 |
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| dbo:wikiPageRevisionID | 1075839701 (xsd:integer) |
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| dbp:altsymbols | KCNJ7, Kir3.2, GIRK2, KATP2, BIR1, hiGIRK2 (en) Kir3.1, GIRK1, KGA (en) Kir3.3, GIRK3 (en) Kir3.4, CIR, KATP1, GIRK4 (en) |
| dbp:arm | q (en) |
| dbp:band | 22.100000 (xsd:double) 23.200000 (xsd:double) 24 (xsd:integer) 24.100000 (xsd:double) |
| dbp:chromosome | 1 (xsd:integer) 2 (xsd:integer) 11 (xsd:integer) 21 (xsd:integer) |
| dbp:entrezgene | 3760 (xsd:integer) 3762 (xsd:integer) 3763 (xsd:integer) 3765 (xsd:integer) |
| dbp:hgncid | 6264 (xsd:integer) 6266 (xsd:integer) 6267 (xsd:integer) 6270 (xsd:integer) |
| dbp:iupharId | yes (en) |
| dbp:name | dbr:KCNJ3 dbr:KCNJ5 dbr:KCNJ6 dbr:KCNJ9 |
| dbp:omim | 600734 (xsd:integer) 600877 (xsd:integer) 600932 (xsd:integer) 601534 (xsd:integer) |
| dbp:refseq | NM_000890 (en) NM_002239 (en) NM_002240 (en) NM_004983 (en) |
| dbp:symbol | KCNJ3 (en) KCNJ5 (en) KCNJ6 (en) KCNJ9 (en) |
| dbp:uniprot | P48051 (en) P48544 (en) P48549 (en) Q92806 (en) |
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| dcterms:subject | dbc:Ion_channels |
| gold:hypernym | dbr:Family |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Act100030358 yago:Channel106259898 yago:Communication106252138 yago:Event100029378 yago:PsychologicalFeature100023100 yago:WikicatIonChannels yago:YagoPermanentlyLocatedEntity dbo:Protein yago:Transmission106251781 umbel-rc:ProteinMolecule |
| rdfs:comment | Le courant potassique rectifiant activé par les protéines G ou GIRK, pour l'anglais G-protein activated Inwardly Rectifying K+ current, appartient à la famille des courants potassiques rectifiant. Le terme rectifiant est ici utilisé en référence au composant électronique, le redresseur ((en) rectifier), qui n'est conducteur que pour une polarité. La séparation du complexe trimèrique des protéines G active ce courant via les sous-unités β (bêta) et γ (gamma). Ce courant entraîne une hyperpolarisation du potentiel de repos qui inhibe le neurone. (fr) G-белок-связанные калиевые каналы внутреннего выпрямления (так называемые GIRK) — это подсемейство калиевых каналов внутреннего выпрямления, которые активируются (открываются) вследствие передачи сигнала с активированного вследствие связывания лиганда-агониста G-белок-связанного рецептора, вследствие чего от G-белка отсоединяется димер из βγ-субъединиц, который и активирует GIRK. Каналы подтипа GIRK1, GIRK2 и GIRK3 широко представлены в ЦНС, где их области распределения частично перекрываются. Каналы подтипа GIRK4, однако, в основном находятся в сердце. (ru) The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of lipid-gated inward-rectifier potassium ion channels which are activated (opened) by the signaling lipid PIP2 and a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits (Gβγ) from inactive heterotrimeric G protein complexes (Gαβγ). Finally, the Gβγ dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions, resulting in hyperpolarization of the cell membrane. G protein-coupled inwardly-rectifying potassium channels are a type of G protein-gated ion channels because of this direct interaction of G protein subunits with GIRK channels. The activation likely works by (en) |
| rdfs:label | G protein-coupled inwardly-rectifying potassium channel (en) Courant potassique rectifiant activé par les protéines G (fr) GIRK (ru) |
| owl:sameAs | freebase:G protein-coupled inwardly-rectifying potassium channel freebase:G protein-coupled inwardly-rectifying potassium channel yago-res:G protein-coupled inwardly-rectifying potassium channel wikidata:G protein-coupled inwardly-rectifying potassium channel dbpedia-fr:G protein-coupled inwardly-rectifying potassium channel dbpedia-ru:G protein-coupled inwardly-rectifying potassium channel dbpedia-sh:G protein-coupled inwardly-rectifying potassium channel dbpedia-sr:G protein-coupled inwardly-rectifying potassium channel dbpedia-tr:G protein-coupled inwardly-rectifying potassium channel https://global.dbpedia.org/id/2nQJd |
| prov:wasDerivedFrom | wikipedia-en:G_protein-coupled_inwardly-rectifying_potassium_channel?oldid=1075839701&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:G_protein-coupled_inwardly-rectifying_potassium_channel |
| foaf:name | potassium inwardly-rectifying channel, subfamily J, member 9 (en) potassium inwardly-rectifying channel, subfamily J, member 6 (en) potassium inwardly-rectifying channel, subfamily J, member 3 (en) potassium inwardly-rectifying channel, subfamily J, member 5 (en) |
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