Human herpesvirus 6 (original) (raw)
الفيروس الهربسي البشري 6 (بالإنجليزية: Human herpesvirus 6 or HHV-6) هو الاسم الجامع الشائع للفيروس الهربسي البشري 6 أ والفيروس الهربسي البشري 6 ب، هذه الفيروسات تربطها صلة وثيقة وهما من أنواع الهربس التسعة المعروف أن مضيفها الابتدائي هو البشر.
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| dbo:abstract | الفيروس الهربسي البشري 6 (بالإنجليزية: Human herpesvirus 6 or HHV-6) هو الاسم الجامع الشائع للفيروس الهربسي البشري 6 أ والفيروس الهربسي البشري 6 ب، هذه الفيروسات تربطها صلة وثيقة وهما من أنواع الهربس التسعة المعروف أن مضيفها الابتدائي هو البشر. (ar) Das Humane Herpesvirus Typ 6A und 6B (HHV-6A und 6B) sind zwei humanpathogene Spezies (Arten) von Viren in der Gattung Herpesvirus aus der Unterfamilie der Betaherpesviren. Das International Committee on Taxonomy of Viruses (ICTV) hat die frühere Virusspezies (Humanes) Herpesvirus 6 mit Stand März 2019 aufgeteilt und die beiden Subtypen A und B in den Rang von Spezies erhoben. HHV-6B ist der Verursacher des Drei-Tage-Fiebers (Exanthema subitum alias Roseola infantum, „Sechste Krankheit“), einer Erkrankung, die vorwiegend im Säuglings- oder frühen Kleinkindalter auftritt. Mit der Spezies HHV-6A (dem früheren HHV-6-Subtyp A) konnten bisher keine Erkrankungen assoziiert werden. Eine Beteiligung dieser Viren an anderen Erkrankungen wird diskutiert. (de) Human herpesvirus 6 (HHV-6) o herpesvirus humano 6, también conocido antiguamente como human B-lymphotropic virus (HBLV) o virus linfotrópico B humano es un virus de la familia Herpesviridae, uno de los 8 (HHV-1 a HHV-8) que infecta a los humanos. Existen dos subtipos de HHV-6, denominados HHV-6A (el virus linfotrópico B humano) y HHV-6B (relacionado con la roseola infantil). La especie fue aislada por primera vez en 1986 a partir de linfocitos de pacientes afectados por desórdenes linforreticulares. (es) Human herpesvirus 6 (HHV-6) is the common collective name for human betaherpesvirus 6A (HHV-6A) and human betaherpesvirus 6B (HHV-6B). These closely related viruses are two of the nine known herpesviruses that have humans as their primary host. HHV-6A and HHV-6B are double-stranded DNA viruses within the Betaherpesvirinae subfamily and of the genus Roseolovirus. HHV-6A and HHV-6B infect almost all of the human populations that have been tested. HHV-6A has been described as more neurovirulent, and as such is more frequently found in patients with neuroinflammatory diseases such as multiple sclerosis. HHV-6 (and HHV-7) levels in the brain are also elevated in people with Alzheimer's disease. HHV-6B primary infection is the cause of the common childhood illness exanthema subitum (also known as roseola infantum or sixth disease). It is passed on from child to child. It is uncommon for adults to contract this disease as most people have had it by kindergarten, and once contracted, immunity arises and prevents future reinfection. Additionally, HHV-6B reactivation is common in transplant recipients, which can cause several clinical manifestations such as encephalitis, bone marrow suppression, and pneumonitis. A variety of tests are used in the detection of HHV-6, some of which do not differentiate the two species. (en) L'herpèsvirus humain type 6 (HHV-6 — Human Herpesvirus - 6) est l'un des 8 membres connus de la famille des herpesvirus humain. La particularité de HHV-6 est qu'il s'intègre dans le génome de l'hôte qu'il a infecté (pas toujours). Ainsi en cas de dépistage, il faut se méfier d'un résultat positif. HHV-6 est un membre des (une sous-famille des Herpesviridae) qui inclut aussi HHV-7 et CMV (cytomégalovirus). La prévalence de HHV-6 est très élevée partout dans le monde, la plupart des revues s'accorde pour une prévalence supérieure à 85 % chez l'adulte. Il y a deux variants de HHV-6 : et . HHV-6B est responsable d'une grande majorité des infections primaires, avec probablement des différences de distributions entre HHV-6A et HHV-6B selon les régions du monde. L'infection par HHV-6 cause habituellement une fièvre avec un exanthème subit (exanthem subitum) qui est une éruption cutanée plus connue sous le nom de roséole et rapportée dans 10 % des cas. L'infection à HHV-6 est aussi associée à des complications sévères comme l'encéphalite, les lymphadénopathies, les myocardites et la . Il semble par ailleurs de plus en plus probable que HHV-6A, plus neurotropique que HHV-6B, soit associé au développement de la sclérose en plaques. On a bien entendu des complications supplémentaires chez les immunodéprimées comme pour toutes les infections à Herpesviridae. Chez l'enfant, il donne des convulsions (première cause de convulsions infantiles) et peut donner de la fièvre jusqu'à 44°C dans les formes les plus graves de méningites. Après l'infection primaire, le virus établit une latence persistant tout au long de la vie dans les progéniteurs myéloïdes et la moelle osseuse. Le virus est réactivé périodiquement de sa latence, et l'ADN viral est détectable chez 20-25 % de la population adulte saine aux États-Unis. Chez les immunocompétents, cette réactivation est asymptomatique, mais peut résulter en des complications sérieuses chez les immunosupprimés, notamment chez les transplantés. La réactivation de HHV-6, associée à celle d'autres , peut être responsable du rejet de la greffe. Chez les patients atteints de SIDA, la réactivation peut causer des infections disséminées graves. Des renseignements supplémentaires sur HHV-6 sont aussi présents dans l'article : « Prevalence of herpesvirus DNA in MS patients and healthy blood donors » (fr) ヒトヘルペスウイルス6 (Human herpesvirus 6; HHV-6)は、ヒトを主要な宿主とするヘルペスウイルス9種のうち、Human betaherpesvirus 6A (HHV-6A)およびHuman betaherpesvirus 6B (HHV-6B)の2種の総称である。ウイルス学上はともにベータヘルペスウイルス亜科ロゼオロウイルス属に所属させる。 (ja) L'herpesvirus umano 6 (Human herpesvirus 6) o HHV-6 è un Betaherpesvirus della famiglia degli Herpesviridae. È stato scoperto nel 1986 in pazienti affetti da AIDS che presentavano una patologia linfoproliferativa. Sono conosciute due varianti virali (HHV-6A e HHV-6B), che sono considerate specie diverse (1), in quanto differiscono per tropismo cellulare, associazione con malattie, profilo immunologico, ecc. HHV-6B è molto diffuso, tant'è che la prima infezione avviene generalmente entro i primi due anni di vita. Allora può presentarsi sotto la tipica forma della Roseola infantum, detta VI malattia. Anche HHV-6A infetta la popolazione umana, ma con frequenza minore, e non si conoscono con precisione la malattie associate all'infezione primaria. Come tutti gli herpesvirus, entrambe le varianti possono rimanere latente e riattivarsi in seguito alla depressione del sistema immunitario (com'era nei pazienti AIDS in cui fu isolato). Il virus ha un particolare tropismo verso i linfociti T, soprattutto i CD4+. Tuttavia infetta anche gli altri T, le cellule Natural Killer, astrociti e monociti. Il recettore per HHV-6A è la glicoproteina CD46, che è diffusa in moltissimi tipi cellulari umani, mentre il recettore per HHV-6B è la molecola CD134. 1) https://www.ncbi.nlm.nih.gov/pubmed/24193951 (it) Вирусы герпеса человека 6 типа — общее название для герпесвирусов человека 6А и 6B. В 2012 году эти вирусы были классифицированы как отдельные виды. В 2016 году были переименованы для отображения подсемейства, к которому относится. (ru) Humant herpesvirus 6 eller HHV-6 är ett samlingsnamn för HHV-6A och HHV-6B, som är två mycket närbesläktade virus tillhörande gruppen betaherpesvirinae. Både HHV-6A och HHV-6B är så kallade linjära dubbelsträngade DNA-virus. Under dess produceras viruspartiklar som består av ett proteinskal som innehåller virala dsDNA-strängar. Viruset går in i kroppens celler via -receptorn, som är en del av kroppens ospecifika immunförsvar. Exakt hur detta går till är inte fullt utrett. (sv) Herpesvírus humano 6 (HHV-6) é o nome coletivo comum para o (HHV-6A) e o (HHV-6B). Esses vírus intimamente relacionados são dois dos nove herpesvírus conhecidos por possuir seres humanos como hospedeiro principal. HHV-6A e HHV-6B são vírus de DNA de fita dupla na subfamília Betaherpesvirinae e do gênero Roseolovirus. HHV-6A e HHV-6B infectam quase todas as populações humanas que foram testadas. O HHV-6A foi descrito como mais , e, como tal, é mais frequentemente encontrado em pacientes com doenças neuroinflamatórias, como esclerose múltipla. Os níveis de HHV-6 (e HHV-7) no cérebro também são elevados em pessoas com doença de Alzheimer. A infecção primária pelo HHV-6B é a causa do exantema súbito comum da infância (também conhecida como roséola infantil ou sexta doença). Além disso, a reativação do HHV-6B é comum em receptores de transplante, o que pode causar várias manifestações clínicas, como encefalite, supressão da medula óssea e pneumonite. Uma variedade de testes é usada na detecção do HHV-6, alguns dos quais não diferenciam as duas espécies. (pt) |
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| dbp:auto | virus (en) |
| dbp:excludes | All other Roseolovirus spp.: * Human betaherpesvirus 7 * Macacine betaherpesvirus 9 * Murid betaherpesvirus 3 * Suid betaherpesvirus 2 (en) |
| dbp:image | Hhv-6.jpg (en) |
| dbp:image2Caption | HHV-6 released from a lymphocyte which has been infected (en) |
| dbp:imageAlt | Electron micrograph of one of the HHV6 species (en) |
| dbp:imageCaption | Electron micrograph of one of the HHV6 species (en) |
| dbp:includes | * Human betaherpesvirus 6A * Human betaherpesvirus 6B (en) |
| dbp:name | Human herpesvirus 6 (en) |
| dbp:parent | Roseolovirus (en) |
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| dct:subject | dbc:Betaherpesvirinae dbc:Viruses_articles_needing_expert_attention dbc:Unaccepted_virus_taxa |
| gold:hypernym | dbr:Name |
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| rdfs:comment | الفيروس الهربسي البشري 6 (بالإنجليزية: Human herpesvirus 6 or HHV-6) هو الاسم الجامع الشائع للفيروس الهربسي البشري 6 أ والفيروس الهربسي البشري 6 ب، هذه الفيروسات تربطها صلة وثيقة وهما من أنواع الهربس التسعة المعروف أن مضيفها الابتدائي هو البشر. (ar) Human herpesvirus 6 (HHV-6) o herpesvirus humano 6, también conocido antiguamente como human B-lymphotropic virus (HBLV) o virus linfotrópico B humano es un virus de la familia Herpesviridae, uno de los 8 (HHV-1 a HHV-8) que infecta a los humanos. Existen dos subtipos de HHV-6, denominados HHV-6A (el virus linfotrópico B humano) y HHV-6B (relacionado con la roseola infantil). La especie fue aislada por primera vez en 1986 a partir de linfocitos de pacientes afectados por desórdenes linforreticulares. (es) ヒトヘルペスウイルス6 (Human herpesvirus 6; HHV-6)は、ヒトを主要な宿主とするヘルペスウイルス9種のうち、Human betaherpesvirus 6A (HHV-6A)およびHuman betaherpesvirus 6B (HHV-6B)の2種の総称である。ウイルス学上はともにベータヘルペスウイルス亜科ロゼオロウイルス属に所属させる。 (ja) Вирусы герпеса человека 6 типа — общее название для герпесвирусов человека 6А и 6B. В 2012 году эти вирусы были классифицированы как отдельные виды. В 2016 году были переименованы для отображения подсемейства, к которому относится. (ru) Humant herpesvirus 6 eller HHV-6 är ett samlingsnamn för HHV-6A och HHV-6B, som är två mycket närbesläktade virus tillhörande gruppen betaherpesvirinae. Både HHV-6A och HHV-6B är så kallade linjära dubbelsträngade DNA-virus. Under dess produceras viruspartiklar som består av ett proteinskal som innehåller virala dsDNA-strängar. Viruset går in i kroppens celler via -receptorn, som är en del av kroppens ospecifika immunförsvar. Exakt hur detta går till är inte fullt utrett. (sv) Das Humane Herpesvirus Typ 6A und 6B (HHV-6A und 6B) sind zwei humanpathogene Spezies (Arten) von Viren in der Gattung Herpesvirus aus der Unterfamilie der Betaherpesviren. Das International Committee on Taxonomy of Viruses (ICTV) hat die frühere Virusspezies (Humanes) Herpesvirus 6 mit Stand März 2019 aufgeteilt und die beiden Subtypen A und B in den Rang von Spezies erhoben. (de) Human herpesvirus 6 (HHV-6) is the common collective name for human betaherpesvirus 6A (HHV-6A) and human betaherpesvirus 6B (HHV-6B). These closely related viruses are two of the nine known herpesviruses that have humans as their primary host. HHV-6A and HHV-6B are double-stranded DNA viruses within the Betaherpesvirinae subfamily and of the genus Roseolovirus. HHV-6A and HHV-6B infect almost all of the human populations that have been tested. A variety of tests are used in the detection of HHV-6, some of which do not differentiate the two species. (en) L'herpèsvirus humain type 6 (HHV-6 — Human Herpesvirus - 6) est l'un des 8 membres connus de la famille des herpesvirus humain. La particularité de HHV-6 est qu'il s'intègre dans le génome de l'hôte qu'il a infecté (pas toujours). Ainsi en cas de dépistage, il faut se méfier d'un résultat positif. Des renseignements supplémentaires sur HHV-6 sont aussi présents dans l'article : « Prevalence of herpesvirus DNA in MS patients and healthy blood donors » (fr) L'herpesvirus umano 6 (Human herpesvirus 6) o HHV-6 è un Betaherpesvirus della famiglia degli Herpesviridae. È stato scoperto nel 1986 in pazienti affetti da AIDS che presentavano una patologia linfoproliferativa. Sono conosciute due varianti virali (HHV-6A e HHV-6B), che sono considerate specie diverse (1), in quanto differiscono per tropismo cellulare, associazione con malattie, profilo immunologico, ecc. Come tutti gli herpesvirus, entrambe le varianti possono rimanere latente e riattivarsi in seguito alla depressione del sistema immunitario (com'era nei pazienti AIDS in cui fu isolato). (it) Herpesvírus humano 6 (HHV-6) é o nome coletivo comum para o (HHV-6A) e o (HHV-6B). Esses vírus intimamente relacionados são dois dos nove herpesvírus conhecidos por possuir seres humanos como hospedeiro principal. HHV-6A e HHV-6B são vírus de DNA de fita dupla na subfamília Betaherpesvirinae e do gênero Roseolovirus. HHV-6A e HHV-6B infectam quase todas as populações humanas que foram testadas. Uma variedade de testes é usada na detecção do HHV-6, alguns dos quais não diferenciam as duas espécies. (pt) |
| rdfs:label | فيروس هربسي بشري 6 (ar) Humanes Herpesvirus 6 (de) Human herpesvirus 6 (es) Human herpesvirus 6 (en) Herpèsvirus humain type 6 (fr) Herpesvirus umano 6 (it) ヒトヘルペスウイルス6 (ja) Herpesvírus humano 6 (pt) Вирусы герпеса человека 6 типа (ru) Humant herpesvirus 6 (sv) |
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