Leonard Hayflick (original) (raw)
Leonard Hayflick (Filadèlfia, 20 de maig de 1928) és un professor d'anatomia a la UCSF School of Medicine i va ser professor de microbiologia mèdica a la Universitat de Stanford. Va ser president la Societat de Geronotologia d'Amèrica. I també va ser un dels membres fundadors del consell del National Institute on Aging (NIA). Ha estudiat el procés d'envelliment de les cèl·lules i és conegut per descobrir que les cèl·lules humanes normals, in vitro, es divideixen un nombre de vegades determinat. Aquest fenomen s'anomena el Límit de Hayflick.
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| dbo:abstract | Leonard Hayflick (Filadèlfia, 20 de maig de 1928) és un professor d'anatomia a la UCSF School of Medicine i va ser professor de microbiologia mèdica a la Universitat de Stanford. Va ser president la Societat de Geronotologia d'Amèrica. I també va ser un dels membres fundadors del consell del National Institute on Aging (NIA). Ha estudiat el procés d'envelliment de les cèl·lules i és conegut per descobrir que les cèl·lules humanes normals, in vitro, es divideixen un nombre de vegades determinat. Aquest fenomen s'anomena el Límit de Hayflick. (ca) ليونارد هايفليك (Leonard Hayflick) عالم أمريكي مختص في علم التشريح، ولد في 20 مايو 1928. (ar) Leonard Hayflick (* 20. Mai 1928 in Philadelphia) ist ein US-amerikanischer Gerontologe. Bekannt wurde er vor allem durch seine Arbeiten auf dem Gebiet der Zellteilung, in denen er zeigte, dass normale Körperzellen sich nur etwa fünfzigmal teilen können und anschließend durch programmierten Zelltod (Apoptose) absterben. Er widerlegte damit die von Alexis Carrel 1908 aufgestellte These, dass sich Zellen von Vertebraten unbegrenzt teilen können und unsterblich sind. (de) Leonard Hayflick (born 20 May 1928) is a Professor of Anatomy at the UCSF School of Medicine, and was Professor of Medical Microbiology at Stanford University School of Medicine. He is a past president of the Gerontological Society of America and was a founding member of the council of the National Institute on Aging (NIA). The recipient of a number of research prizes and awards, including the 1991 Sandoz Prize for Gerontological Research, he has studied the aging process for more than fifty years. He is known for discovering that normal human cells divide for a limited number of times in vitro (refuting the contention by Alexis Carrel that normal body cells are immortal). This is known as the Hayflick limit. His discoveries overturned a 60-year old dogma that all cultured cells are immortal. Hayflick demonstrated that normal cells have a memory and can remember at what doubling level they have reached. He demonstrated that his normal human cell strains were free from contaminating viruses. His cell strain WI-38 soon replaced primary monkey kidney cells and became the substrate for the production of most of the world's human virus vaccines. Hayflick discovered that the etiological agent of primary atypical pneumonia (also called "walking pneumonia") was not a virus as previously believed. He was the first to cultivate the causative organism called a mycoplasma, the smallest free-living organism, which Hayflick isolated on a unique culture medium that bears his name. He named the organism Mycoplasma pneumoniae. In 1959, Hayflick developed the first inverted microscope for use in cell culture research. To this day, all inverted microscopes used in cell culture laboratories worldwide are descended from this prototype. His microscope was accessioned by the Smithsonian Institution in 2009. Hayflick developed the first practical method for producing powdered cell culture media in 1965. This method is now used worldwide for the production of many tons of powdered media annually for use in research laboratories and commercial production facilities. The technique is not patented and Hayflick receives no remuneration from this invention. Hayflick is the author of the book, How and Why We Age, published in August 1994 by Ballantine Books, NYC and available since 1996 as a paperback. This book has been translated into nine languages and is published in Brazil, the Czech Republic, Germany, Hungary, Israel, Japan, Poland, Russia, and Spain. It was a selection of the Book of the Month Club and has sold over 50,000 copies worldwide. Hayflick and his associates have vehemently condemned "anti-aging medicine" and criticized organizations such as the American Academy of Anti-Aging Medicine. Hayflick has written numerous articles criticizing both the feasibility and desirability of human life extension, which have provoked responses critical of his views. (en) Leonard Hayflick est un microbiologiste américain ayant largement contribué à l'avancée des connaissances scientifiques en biologie cellulaire en travaillant notamment sur les cellules souches. Il est à l'origine de la découverte de la lignée de cellules WI-38, première lignée « normale » de cellules souche, ainsi que de la limite de Hayflick. * Portail de la biologie cellulaire et moléculaire * Portail de la Pennsylvanie (fr) レナード・ヘイフリック（Leonard Hayflick, 1928年5月20日 - ）はアメリカ合衆国の生物学者。専門は解剖学、老年学。カリフォルニア大学サンフランシスコ校教授。 (ja) Leonard Hayflick (Filadélfia, 20 de maio de 1928) é um médico dos Estados Unidos da América. É professor de anatomia na Universidade da Califórnia, em San Francisco. Também já foi professor de microbiologia médica na Universidade de Stanford. Leonard estudou o processo de envelhecimento por mais de trinta anos, tendo feito descobertas importantes a respeito da senescência celular e do encurtamento dos telômeros. Segundo Leonard Hayflick as células tem um momento certo para morrer, o tempo de vida delas é de acordo com o tamanho dos telômeros, se os telômeros se encurtam demais a célula morre, o limite de encurtamento dos telômeros ficou conhecido como limite de Hayflick. Leonard Hayflick recebeu diversos prêmios e concessões de pesquisa, dos quais podemos destacar o Sandoz Prize for Gerontological Research, de 1991. (pt) Leonard Hayflick, född 20 maj 1928, är en amerikansk medicinsk forskare, bland annat känd för upptäckten att cellers delning har en gräns, , som för normala fosterceller är omkring 50 delningar. Upptäckten publicerades 1961 och gav upphov till ett nytt : studiet av . (sv) Леонард Хейфлик (англ. Leonard Hayflick; 20 мая 1928, Филадельфия) — профессор анатомии Калифорнийского университета (University of California) в Сан-Франциско, вице-председатель . В 1959 разработал инвертированный микроскоп для исследований культур клеток, до сих пор являющийся прототипом микроскопов, применяемых учёными в этой области. В 1960-е годы открыл ограничение числа делений у клеток человека в клеточной культуре: клетки умирают приблизительно после 50 делений, и имеют признаки старения при достижении данной границы (предел Хейфлика). Автор книги How and Why We Age (1994), переведённой на многие языки. (ru) Леона́рд Ге́йфлік (англ. Leonard Hayflick; *20 травня 1928, Філадельфія, США) — професор анатомії Каліфорнійського університету в Сан-Франциско, був професором кліничної мікробіології в Стенфордському університеті. Він також займав посаду президента і був одним із засновників (NIA). Він досліджував старіння протягом більш ніж 30 років і отримав кілька престижних нагород, зокрема . Леонард Гейфлік відомий насамперед завдяки його відкриттю межі поділу соматичних клітин багатоклітинних організмів, відому зараз як межа Гейфліка. (uk) |
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| dbp:name | Leonard Hayflick (en) |
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| rdfs:comment | Leonard Hayflick (Filadèlfia, 20 de maig de 1928) és un professor d'anatomia a la UCSF School of Medicine i va ser professor de microbiologia mèdica a la Universitat de Stanford. Va ser president la Societat de Geronotologia d'Amèrica. I també va ser un dels membres fundadors del consell del National Institute on Aging (NIA). Ha estudiat el procés d'envelliment de les cèl·lules i és conegut per descobrir que les cèl·lules humanes normals, in vitro, es divideixen un nombre de vegades determinat. Aquest fenomen s'anomena el Límit de Hayflick. (ca) ليونارد هايفليك (Leonard Hayflick) عالم أمريكي مختص في علم التشريح، ولد في 20 مايو 1928. (ar) Leonard Hayflick (* 20. Mai 1928 in Philadelphia) ist ein US-amerikanischer Gerontologe. Bekannt wurde er vor allem durch seine Arbeiten auf dem Gebiet der Zellteilung, in denen er zeigte, dass normale Körperzellen sich nur etwa fünfzigmal teilen können und anschließend durch programmierten Zelltod (Apoptose) absterben. Er widerlegte damit die von Alexis Carrel 1908 aufgestellte These, dass sich Zellen von Vertebraten unbegrenzt teilen können und unsterblich sind. (de) Leonard Hayflick est un microbiologiste américain ayant largement contribué à l'avancée des connaissances scientifiques en biologie cellulaire en travaillant notamment sur les cellules souches. Il est à l'origine de la découverte de la lignée de cellules WI-38, première lignée « normale » de cellules souche, ainsi que de la limite de Hayflick. * Portail de la biologie cellulaire et moléculaire * Portail de la Pennsylvanie (fr) レナード・ヘイフリック（Leonard Hayflick, 1928年5月20日 - ）はアメリカ合衆国の生物学者。専門は解剖学、老年学。カリフォルニア大学サンフランシスコ校教授。 (ja) Leonard Hayflick, född 20 maj 1928, är en amerikansk medicinsk forskare, bland annat känd för upptäckten att cellers delning har en gräns, , som för normala fosterceller är omkring 50 delningar. Upptäckten publicerades 1961 och gav upphov till ett nytt : studiet av . (sv) Леона́рд Ге́йфлік (англ. Leonard Hayflick; *20 травня 1928, Філадельфія, США) — професор анатомії Каліфорнійського університету в Сан-Франциско, був професором кліничної мікробіології в Стенфордському університеті. Він також займав посаду президента і був одним із засновників (NIA). Він досліджував старіння протягом більш ніж 30 років і отримав кілька престижних нагород, зокрема . Леонард Гейфлік відомий насамперед завдяки його відкриттю межі поділу соматичних клітин багатоклітинних організмів, відому зараз як межа Гейфліка. (uk) Leonard Hayflick (born 20 May 1928) is a Professor of Anatomy at the UCSF School of Medicine, and was Professor of Medical Microbiology at Stanford University School of Medicine. He is a past president of the Gerontological Society of America and was a founding member of the council of the National Institute on Aging (NIA). The recipient of a number of research prizes and awards, including the 1991 Sandoz Prize for Gerontological Research, he has studied the aging process for more than fifty years. He is known for discovering that normal human cells divide for a limited number of times in vitro (refuting the contention by Alexis Carrel that normal body cells are immortal). This is known as the Hayflick limit. His discoveries overturned a 60-year old dogma that all cultured cells are immort (en) Leonard Hayflick (Filadélfia, 20 de maio de 1928) é um médico dos Estados Unidos da América. É professor de anatomia na Universidade da Califórnia, em San Francisco. Também já foi professor de microbiologia médica na Universidade de Stanford. Leonard Hayflick recebeu diversos prêmios e concessões de pesquisa, dos quais podemos destacar o Sandoz Prize for Gerontological Research, de 1991. (pt) Леонард Хейфлик (англ. Leonard Hayflick; 20 мая 1928, Филадельфия) — профессор анатомии Калифорнийского университета (University of California) в Сан-Франциско, вице-председатель . В 1959 разработал инвертированный микроскоп для исследований культур клеток, до сих пор являющийся прототипом микроскопов, применяемых учёными в этой области. В 1960-е годы открыл ограничение числа делений у клеток человека в клеточной культуре: клетки умирают приблизительно после 50 делений, и имеют признаки старения при достижении данной границы (предел Хейфлика). (ru) |
| rdfs:label | ليونارد هايفليك (ar) Leonard Hayflick (ca) Leonard Hayflick (de) Leonard Hayflick (fr) Leonard Hayflick (en) レナード・ヘイフリック (ja) Leonard Hayflick (pt) Хейфлик, Леонард (ru) Leonard Hayflick (sv) Леонард Гейфлік (uk) |
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