Immunophilins (original) (raw)
En biologia molecular, les immunofilines són peptidil-prolyl isomerasas citosòliques endògens que interconverteixen les posicions cis i trans. Un exemple és la Ciclofilina A. Les immunofilines són el blanc dels fàrmacs immunosupressors com la , ciclosporina i tacrolimús.
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| dbo:abstract | En biologia molecular, les immunofilines són peptidil-prolyl isomerasas citosòliques endògens que interconverteixen les posicions cis i trans. Un exemple és la Ciclofilina A. Les immunofilines són el blanc dels fàrmacs immunosupressors com la , ciclosporina i tacrolimús. (ca) Bei Immunophilinen handelt es sich um Proteine, die im Inneren tierischer wie auch pflanzlicher Zellen vorkommen. Bisher sind 7 humane Immunophiline bekannt. Sie sind in zahlreichen Organen zu finden, besonders hohe Konzentrationen sind im Gehirn festzustellen. Immunophiline sind z. B. und . (de) In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases (PPI) that catalyze the interconversion between the cis and trans isomers of peptide bonds containing the amino acid proline (Pro). They are chaperone molecules that generally assist in the proper folding of diverse "client" proteins. Immunophilins are traditionally classified into two families that differ in sequence and biochemical characteristics. These two families are: "cyclosporin-binding cyclophilins (CyPs)" and "FK506-binding proteins (FKBPs)". In 2005, a group of dual-family immunophilins (DFI) has been discovered, mostly in unicellular organisms; these DFIs are natural chimera of CyP and FKBPs, fused in either order (CyP-FKBP or FKBP-CyP). Immunophilins act as receptors for immunosuppressive drugs such as sirolimus (rapamycin), cyclosporin (such as CsA) and tacrolimus (FK506), which inhibit the prolyl isomerase activity of the immunophilins. The drug-immunophilin complexes (CsA-CyP and FK506-FKBP) bind to calcineurin, which inhibits the phosphatase activity of calcineurin and engenders the immunosuppressive effects. CsA and FK506 thus affect the calcium-dependent step of T cell response which prevents release of interleukin-2. Immunophilins also form protein complex with ryanodine and inositol triphosphate (IP3) which impacts the release of calcium. FK506 binds with high affinity to other smaller proteins, such as FKBP-12. FKBP-12 and cyclophilins both share common peptide-prolyl isomerase activity. While the majority of the Peptide bonds within proteins exist in trans (planar) conformation because of the partial double-bond nature of the peptide bond, a small fraction occurs in cis. Unlike regular peptide bonds, the X-Pro peptide bond does not adopt the intended trans conformation spontaneously, thus, cis-trans isomerization can be the rate-limiting (slowest) step in the process of protein folding. Immunophilins, with their prolyl isomerase activity, thus function as protein-folding chaperones. (en) Les immunophilines (du grec philein signifiant « aimer ») sont une superfamille de protéines hautement conservées qui aident au repliement et à l’assemblage d’autres protéines. (fr) Las inmunofilinas son peptidil-prolil isomerasas que catalizan la transformación entre las posiciones cis y trans. Las inmunofilinas son una diana de fármacos inmunosupresores como la rapamicina, la ciclosporina y el tacrolimus. Para estos fármacos en particular, inmunofilinas conocidas como la ciclofilina catalizan la isomerización cis-trans de los enlaces peptídicos, en especial los enlaces X-Pro (siendo X cualquier aminoácido y Pro un residuo de prolina). Sin embargo, esta actividad isomerasa no parece estar relacionada con su capacidad de unión a estos fármacos. (es) Le immunofilline sono delle isomerasi citosoliche che si legano ad alta affinità con farmaci aventi attività immunosoppressive. L'attività delle immunofilline è bersaglio degli immunosoppressori e attraverso quest'azione, questi farmaci esercitano la loro attività. Tra queste, la , bersaglio della ciclosporina, e l'FK506 BD bersaglio del tacrolimus. (it) |
| dbo:wikiPageExternalLink | https://web.archive.org/web/20051218081123/http:/pmb.berkeley.edu/faculty/faculty_pages/Luan.html http://www.jbc.org/content/280/26/24308.full |
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| rdfs:comment | En biologia molecular, les immunofilines són peptidil-prolyl isomerasas citosòliques endògens que interconverteixen les posicions cis i trans. Un exemple és la Ciclofilina A. Les immunofilines són el blanc dels fàrmacs immunosupressors com la , ciclosporina i tacrolimús. (ca) Bei Immunophilinen handelt es sich um Proteine, die im Inneren tierischer wie auch pflanzlicher Zellen vorkommen. Bisher sind 7 humane Immunophiline bekannt. Sie sind in zahlreichen Organen zu finden, besonders hohe Konzentrationen sind im Gehirn festzustellen. Immunophiline sind z. B. und . (de) Les immunophilines (du grec philein signifiant « aimer ») sont une superfamille de protéines hautement conservées qui aident au repliement et à l’assemblage d’autres protéines. (fr) Las inmunofilinas son peptidil-prolil isomerasas que catalizan la transformación entre las posiciones cis y trans. Las inmunofilinas son una diana de fármacos inmunosupresores como la rapamicina, la ciclosporina y el tacrolimus. Para estos fármacos en particular, inmunofilinas conocidas como la ciclofilina catalizan la isomerización cis-trans de los enlaces peptídicos, en especial los enlaces X-Pro (siendo X cualquier aminoácido y Pro un residuo de prolina). Sin embargo, esta actividad isomerasa no parece estar relacionada con su capacidad de unión a estos fármacos. (es) Le immunofilline sono delle isomerasi citosoliche che si legano ad alta affinità con farmaci aventi attività immunosoppressive. L'attività delle immunofilline è bersaglio degli immunosoppressori e attraverso quest'azione, questi farmaci esercitano la loro attività. Tra queste, la , bersaglio della ciclosporina, e l'FK506 BD bersaglio del tacrolimus. (it) In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases (PPI) that catalyze the interconversion between the cis and trans isomers of peptide bonds containing the amino acid proline (Pro). They are chaperone molecules that generally assist in the proper folding of diverse "client" proteins. Immunophilins are traditionally classified into two families that differ in sequence and biochemical characteristics. These two families are: "cyclosporin-binding cyclophilins (CyPs)" and "FK506-binding proteins (FKBPs)". In 2005, a group of dual-family immunophilins (DFI) has been discovered, mostly in unicellular organisms; these DFIs are natural chimera of CyP and FKBPs, fused in either order (CyP-FKBP or FKBP-CyP). (en) |
| rdfs:label | Immunofilina (ca) Immunophiline (de) Inmunofilina (es) Immunophilins (en) Immunophiline (fr) Immunofillina (it) |
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