| dbo:abstract |
The enzyme indole-3-glycerol-phosphate synthase (IGPS) (EC 4.1.1.48) catalyzes the chemical reaction 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate 1-C-(indol-3-yl)-glycerol 3-phosphate + CO2 + H2O This enzyme belongs to the family of lyases, to be specific, the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing 1-C-(indol-3-yl)glycerol-3-phosphate-forming]. Other names in common use include indoleglycerol phosphate synthetase, indoleglycerol phosphate synthase, indole-3-glycerophosphate synthase, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate, and carboxy-lyase (cyclizing). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and two-component system - general. It employs one cofactor, pyruvate. (en) |
| dbo:ecNumber |
4.1.1.48 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/3t55.jpg?width=300 |
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14284288 (xsd:integer) |
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4858 (xsd:nonNegativeInteger) |
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1100543942 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:List_of_enzymes dbr:C-terminal dbc:Pyruvate_enzymes dbc:Enzymes_of_known_structure dbr:Chemical_reaction dbr:Enzyme dbr:Fungi dbr:Archaeon dbr:Protein_Data_Bank dbr:Bacteria dbr:Tryptophan dbr:Tyrosine dbr:Alpha_helix dbr:Escherichia_coli dbr:Glutamine_amidotransferase dbr:Protein_domain dbc:EC_4.1.1 dbc:Protein_domains dbr:Biocatalysis dbr:Sulfolobus dbr:Cofactor_(biochemistry) dbr:Tertiary_structure dbr:Monomeric dbr:Phenylalanine dbr:Catalysis dbr:Lyase dbr:Phosphoribosylanthranilate_isomerase dbr:Mesophilic dbr:Hyperthermophilic dbr:Secondary_structure dbr:N-terminal dbr:Pyruvate dbr:Beta_strand dbr:Biosynthesis_of_proteins |
| dbp:caption |
Indole-3-glycerol-phosphate synthase monomer, Mycobacterium tuberculosis (en) three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from escherichia coli refined at 2.0 angstroms resolution (en) |
| dbp:casNumber |
9031 (xsd:integer) |
| dbp:ecNumber |
4.100000 (xsd:double) |
| dbp:goCode |
4425 (xsd:integer) |
| dbp:interpro |
IPR013798 (en) |
| dbp:iubmbEcNumber |
4 (xsd:integer) |
| dbp:name |
Indole-3-glycerol phosphate synthase (en) indole-3-glycerol-phosphate synthase (en) |
| dbp:pfam |
PF00218 (en) |
| dbp:pfamClan |
CL0036 (en) |
| dbp:prosite |
PDOC00536 (en) |
| dbp:scop |
1 (xsd:integer) |
| dbp:symbol |
IGPS (en) |
| dbp:width |
270 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:4.1-enzyme-stub dbt:Carbon-carbon_lyases dbt:Cite_journal dbt:EC_number dbt:EnzExplorer dbt:Enzyme dbt:Enzymes dbt:Infobox_protein_family dbt:InterPro_content dbt:PDB_link dbt:Portal_bar dbt:Reflist |
| dcterms:subject |
dbc:Pyruvate_enzymes dbc:Enzymes_of_known_structure dbc:EC_4.1.1 dbc:Protein_domains |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Attribute100024264 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Environment113934596 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme yago:Situation113927383 yago:Sphere114514039 yago:State100024720 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatEnzymesOfKnownStructure yago:WikicatProteinDomains yago:WikicatPyruvateEnzymes |
| rdfs:comment |
The enzyme indole-3-glycerol-phosphate synthase (IGPS) (EC 4.1.1.48) catalyzes the chemical reaction 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate 1-C-(indol-3-yl)-glycerol 3-phosphate + CO2 + H2O (en) |
| rdfs:label |
Indole-3-glycerol-phosphate synthase (en) |
| owl:sameAs |
freebase:Indole-3-glycerol-phosphate synthase http://www4.wiwiss.fu-berlin.de/drugbank/resource/targets/2797 http://www4.wiwiss.fu-berlin.de/drugbank/resource/targets/5134 yago-res:Indole-3-glycerol-phosphate synthase wikidata:Indole-3-glycerol-phosphate synthase dbpedia-sh:Indole-3-glycerol-phosphate synthase dbpedia-sr:Indole-3-glycerol-phosphate synthase https://global.dbpedia.org/id/4nTEx |
| prov:wasDerivedFrom |
wikipedia-en:Indole-3-glycerol-phosphate_synthase?oldid=1100543942&ns=0 |
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wiki-commons:Special:FilePath/3t55.jpg wiki-commons:Special:FilePath/PDB_1pii_EBI.jpg |
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wikipedia-en:Indole-3-glycerol-phosphate_synthase |
| foaf:name |
indole-3-glycerol-phosphate synthase (en) |
| is dbo:wikiPageRedirects of |
dbr:EC_4.1.1.48 dbr:1-(2-carboxyphenylamino)-1-deoxy-D-rib...ol-3-yl)glycerol-3-phosphate-forming) |
| is dbo:wikiPageWikiLink of |
dbr:Trp_operon dbr:List_of_EC_numbers_(EC_4) dbr:List_of_MeSH_codes_(D08) dbr:TIM_barrel dbr:EC_4.1.1.48 dbr:1-(2-carboxyphenylamino)-1-deoxy-D-rib...ol-3-yl)glycerol-3-phosphate-forming) |
| is foaf:primaryTopic of |
wikipedia-en:Indole-3-glycerol-phosphate_synthase |
