Interleukin-10 receptor (original) (raw)
Interleukin-10 receptor (IL-10R) is a type II cytokine receptor. The receptor is tetrameric, composed of 2α and 2β subunits. The α subunit (encoded in the Il10ra gene) is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the β subunit (encoded in the Il10rb gene) is expressed ubiquitously. The α subunit is exclusive to interleukin-10, however the β subunit is shared with other type II cytokine receptors such as IL-22R, IL-26R and INFλR.
| Property | Value |
|---|---|
| dbo:abstract | Interleukin-10 receptor (IL-10R) is a type II cytokine receptor. The receptor is tetrameric, composed of 2α and 2β subunits. The α subunit (encoded in the Il10ra gene) is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the β subunit (encoded in the Il10rb gene) is expressed ubiquitously. The α subunit is exclusive to interleukin-10, however the β subunit is shared with other type II cytokine receptors such as IL-22R, IL-26R and INFλR. The IL-10Rα subunit acts as the ligand binding site and may be upregulated in various cell types as necessary. The IL-10Rβ functions as the signaling subunit and is constitutively expressed in a majority of cell types. There is evidence that upon ligand binding at the α subunit, a conformational change occurs in the β subunit that allows it to additionally bind to IL-10. This structure forms a heterotetramer that leads to the signaling complex activation of JAK1 and TYK2 kinases. JAK1 associates with the α subunit, and TYK2 with the β subunit where they then phosphorylate portions of the α subunit. This recruits STAT3, which is additionally phosphorylated by JAK1 and TYK2. STAT3 homodimerizes, moves to the cellular nucleus, and activates gene transcription. The Interleukin-10 receptor is implicated in regulation of gastro-intestinal immune response, primarily in the mucosal layer. Murine studies of test subjects lacking functional receptors showed rapid onset of bowl inflammatory disorders. In human studies, the early onset of irritable bowel disease has been correlated with defects in the IL-10R subunits. Cases involving both the α and β subunits were identified, some possessing fully dysfunctional receptors, and others being incapable of accepting phosphorylation. (en) |
| dbo:arm | q |
| dbo:band | 23 22.1-22.2 |
| dbo:chromosome | 11 21 |
| dbo:entrezgene | 3588 3587 |
| dbo:hgncid | 5965 5964 |
| dbo:omim | 123889 (xsd:integer) 146933 (xsd:integer) |
| dbo:refseq | NM_000628 NM_001558 |
| dbo:symbol | CRFB4, D21S58, D21S66 IL10R IL10RA IL10RB |
| dbo:uniprot | Q08334 Q13651 |
| dbo:wikiPageID | 15668482 (xsd:integer) |
| dbo:wikiPageLength | 5472 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1075841186 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Interleukin-22_receptor dbr:Interleukin_10 dbr:Interleukin_10_receptor,_alpha_subunit dbr:Interleukin_10_receptor,_beta_subunit dbr:Interleukin_26 dbr:Dendritic_cell dbc:Type_II_cytokine_receptors dbr:STAT3 dbr:Type_II_cytokine_receptor dbr:JAK1 dbr:TYK2 |
| dbp:altsymbols | CRFB4, D21S58, D21S66 (en) IL10R (en) |
| dbp:arm | q (en) |
| dbp:band | 22.100000 (xsd:double) 23 (xsd:integer) |
| dbp:chromosome | 11 (xsd:integer) 21 (xsd:integer) |
| dbp:entrezgene | 3587 (xsd:integer) 3588 (xsd:integer) |
| dbp:hgncid | 5964 (xsd:integer) 5965 (xsd:integer) |
| dbp:name | dbr:Interleukin_10_receptor,_alpha_subunit dbr:Interleukin_10_receptor,_beta_subunit |
| dbp:omim | 123889 (xsd:integer) 146933 (xsd:integer) |
| dbp:refseq | NM_000628 (en) NM_001558 (en) |
| dbp:symbol | dbr:Interleukin_10_receptor,_alpha_subunit dbr:Interleukin_10_receptor,_beta_subunit |
| dbp:uniprot | Q08334 (en) Q13651 (en) |
| dbp:wikiPageUsesTemplate | dbt:Membrane-protein-stub dbt:MeshName dbt:Reflist dbt:Short_description dbt:Interleukin_receptor_modulators dbt:Infobox_protein dbt:Cytokine_receptors |
| dct:subject | dbc:Type_II_cytokine_receptors |
| gold:hypernym | dbr:Receptor |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:WikicatTypeIICytokineReceptors yago:BodyPart105220461 yago:Part109385911 yago:PhysicalEntity100001930 yago:Receptor105608868 dbo:Protein yago:Structure105225602 yago:Thing100002452 umbel-rc:ProteinMolecule |
| rdfs:comment | Interleukin-10 receptor (IL-10R) is a type II cytokine receptor. The receptor is tetrameric, composed of 2α and 2β subunits. The α subunit (encoded in the Il10ra gene) is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the β subunit (encoded in the Il10rb gene) is expressed ubiquitously. The α subunit is exclusive to interleukin-10, however the β subunit is shared with other type II cytokine receptors such as IL-22R, IL-26R and INFλR. (en) |
| rdfs:label | Interleukin-10 receptor (en) |
| owl:sameAs | freebase:Interleukin-10 receptor wikidata:Interleukin-10 receptor https://global.dbpedia.org/id/4nsfg |
| prov:wasDerivedFrom | wikipedia-en:Interleukin-10_receptor?oldid=1075841186&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Interleukin-10_receptor |
| foaf:name | interleukin 10 receptor, alpha (en) interleukin 10 receptor, beta (en) |
| is dbo:wikiPageRedirects of | dbr:IL10R dbr:Interleukin_10_receptor |
| is dbo:wikiPageWikiLink of | dbr:Index_of_immunology_articles dbr:Interleukin-28_receptor dbr:Interleukin_10_receptor,_alpha_subunit dbr:Interleukin_10_receptor,_beta_subunit dbr:Interleukin_22 dbr:Chromosome_21 dbr:Tumor_microenvironment dbr:IL10R dbr:Interleukin_10_receptor |
| is foaf:primaryTopic of | wikipedia-en:Interleukin-10_receptor |