| dbo:abstract |
Interleukin-28 receptor is a type II cytokine receptor found largely in epithelial cells. It binds type 3 interferons, interleukin-28 A (Interferon lambda 1), Interleukin-28B (Interferon lambda 2), interleukin 29 (Interferon lambda 3) and interferon lambda 4. It consists of an α chain and shares a common β subunit with the interleukin-10 receptor. Binding to the interleukin-28 receptor, which is restricted to select cell types, is important for fighting infection. Binding of the type 3 interferons to the receptor results in activation of the JAK/STAT signaling pathway. (en) |
| dbo:arm |
p q |
| dbo:band |
36.11 22.1-22.2 |
| dbo:chromosome |
1 21 |
| dbo:entrezgene |
3588 163702 |
| dbo:hgncid |
5965 18584 |
| dbo:omim |
123889 (xsd:integer) 607404 (xsd:integer) |
| dbo:refseq |
NM_000628 NM_170743 |
| dbo:symbol |
CRF2/12, IFNLR, IL-28R1 CRFB4, D21S58, D21S66 IL10RB IL28RA |
| dbo:uniprot |
Q08334 Q8IU57 |
| dbo:wikiPageID |
15668560 (xsd:integer) |
| dbo:wikiPageLength |
10657 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1030258016 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Epidermis dbr:Natural_killer_cell dbr:MHC_class_I dbr:Memory_T_cell dbr:Monocyte dbr:Cytotoxic_T_cell dbr:Interferon-alpha/beta_receptor dbr:Interleukin-10_receptor dbr:Interleukin_10 dbr:Interleukin_10_receptor,_beta_subunit dbr:Interleukin_13 dbr:Interleukin_20 dbr:Interleukin_22 dbr:Interleukin_26 dbr:Interleukin_28_receptor,_alpha_subunit dbr:Interleukin_29 dbr:Interleukin_5 dbr:Interleukin_6 dbr:JAK-STAT_signaling_pathway dbr:Phosphoinositide_3-kinase dbr:STAT5 dbr:Dendritic_cell dbc:Type_II_cytokine_receptors dbr:Keratinocyte dbr:T_helper_cell dbr:Janus_kinase_1 dbr:Transcription_factor dbr:B_cell dbr:STAT3 dbr:Type_II_cytokine_receptor dbr:Suppressor_of_cytokine_signalling dbr:Interferon_gamma dbr:Interleukin_28B dbr:Macrophage dbr:Tyrosine_kinase_2 dbr:IRF9 dbr:STAT1 dbr:T_cell dbr:Tyrosine_kinase dbr:Interferon_Lambda_4 dbr:STAT4 dbr:STAT2 dbr:Melanocytes dbr:MAPK dbr:Interleukin-28 dbr:Interleukin-8 |
| dbp:altsymbols |
CRF2/12, IFNLR, IL-28R1 (en) CRFB4, D21S58, D21S66 (en) |
| dbp:arm |
p (en) q (en) |
| dbp:band |
22.100000 (xsd:double) 36.110000 (xsd:double) |
| dbp:chromosome |
1 (xsd:integer) 21 (xsd:integer) |
| dbp:entrezgene |
3588 (xsd:integer) 163702 (xsd:integer) |
| dbp:hgncid |
5965 (xsd:integer) 18584 (xsd:integer) |
| dbp:name |
dbr:Interleukin_10_receptor,_beta_subunit dbr:Interleukin_28_receptor,_alpha_subunit |
| dbp:omim |
123889 (xsd:integer) 607404 (xsd:integer) |
| dbp:refseq |
NM_000628 (en) NM_170743 (en) |
| dbp:symbol |
dbr:Interleukin_10_receptor,_beta_subunit dbr:Interleukin_28_receptor,_alpha_subunit |
| dbp:uniprot |
Q08334 (en) Q8IU57 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Membrane-protein-stub dbt:MeshName dbt:Reflist dbt:Short_description dbt:Interleukin_receptor_modulators dbt:Infobox_protein dbt:Cytokine_receptor_modulators dbt:Cytokine_receptors |
| dct:subject |
dbc:Type_II_cytokine_receptors |
| gold:hypernym |
dbr:Receptor |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:WikicatTypeIICytokineReceptors yago:BodyPart105220461 yago:Part109385911 yago:PhysicalEntity100001930 yago:Receptor105608868 dbo:Protein yago:Structure105225602 yago:Thing100002452 umbel-rc:ProteinMolecule |
| rdfs:comment |
Interleukin-28 receptor is a type II cytokine receptor found largely in epithelial cells. It binds type 3 interferons, interleukin-28 A (Interferon lambda 1), Interleukin-28B (Interferon lambda 2), interleukin 29 (Interferon lambda 3) and interferon lambda 4. It consists of an α chain and shares a common β subunit with the interleukin-10 receptor. Binding to the interleukin-28 receptor, which is restricted to select cell types, is important for fighting infection. Binding of the type 3 interferons to the receptor results in activation of the JAK/STAT signaling pathway. (en) |
| rdfs:label |
Interleukin-28 receptor (en) |
| owl:sameAs |
freebase:Interleukin-28 receptor wikidata:Interleukin-28 receptor https://global.dbpedia.org/id/4nkTt |
| prov:wasDerivedFrom |
wikipedia-en:Interleukin-28_receptor?oldid=1030258016&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:Interleukin-28_receptor |
| foaf:name |
interleukin 28 receptor, alpha (interferon, lambda receptor) (en) interleukin 10 receptor, beta (en) |
| is dbo:wikiPageRedirects of |
dbr:IFNLR dbr:IL28R dbr:Interferon-lambda_receptor dbr:Interferon_lambda_receptor dbr:Interleukin_28_receptor |
| is dbo:wikiPageWikiLink of |
dbr:Index_of_immunology_articles dbr:Interleukin dbr:Interleukin_28_receptor,_alpha_subunit dbr:IFNLR dbr:IL28R dbr:Interferon-lambda_receptor dbr:Interferon_lambda_receptor dbr:Interleukin_28_receptor |
| is foaf:primaryTopic of |
wikipedia-en:Interleukin-28_receptor |
