STAT4 (original) (raw)
Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT5A, STAT5B, STAT6. STAT proteins are key activators of gene transcription which bind to DNA in response to cytokine gradient. STAT proteins are a common part of Janus kinase (JAK)- signalling pathways, activated by cytokines.STAT4 is required for the development of Th1 cells from naive CD4+ T cells and IFN-γ production in response to IL-12. There are two known STAT4 transcripts, STAT4α and STAT4β, differing in the levels of interferon-gamma (IFN-γ )production downstream.
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| dbo:abstract | Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT5A, STAT5B, STAT6. STAT proteins are key activators of gene transcription which bind to DNA in response to cytokine gradient. STAT proteins are a common part of Janus kinase (JAK)- signalling pathways, activated by cytokines.STAT4 is required for the development of Th1 cells from naive CD4+ T cells and IFN-γ production in response to IL-12. There are two known STAT4 transcripts, STAT4α and STAT4β, differing in the levels of interferon-gamma (IFN-γ )production downstream. (en) STAT-4 (bahasa Inggris: signal transducer and activator of transcription 4, SLEB11, STAT4) adalah salah satu faktor transkripsi dari keluarga protein STAT. Protein ini sangat berperan sebagai mediasi respon IL-12 terhadap limfosit, dan diferensiasi sel TH. (in) STAT4 (acronimo in lingua inglese di signal transducer and activator of transcription 4 o trasduttore e attivatore del segnale di trascrizione 4) è un gene umano. La proteina codificata è una delle proteine STAT della famiglia dei fattori di trascrizione. (it) STAT4是转录因子中信号转导及转录激活蛋白（STAT蛋白）家族的一员。在幼稚CD4+ T cells发育为Th1细胞的过程和细胞响应产生IFN-γ的过程中是必需的。 (zh) STAT4 (англ. Signal transducer and activator of transcription 4) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. Довжина поліпептидного ланцюга білка становить 748 амінокислот, а молекулярна маса — 85 941. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до активаторів, фосфопротеїнів. Задіяний у таких біологічних процесах як транскрипція, регуляція транскрипції, поліморфізм. Білок має сайт для зв'язування з ДНК. Локалізований у цитоплазмі, ядрі. (uk) |
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| rdfs:comment | Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT5A, STAT5B, STAT6. STAT proteins are key activators of gene transcription which bind to DNA in response to cytokine gradient. STAT proteins are a common part of Janus kinase (JAK)- signalling pathways, activated by cytokines.STAT4 is required for the development of Th1 cells from naive CD4+ T cells and IFN-γ production in response to IL-12. There are two known STAT4 transcripts, STAT4α and STAT4β, differing in the levels of interferon-gamma (IFN-γ )production downstream. (en) STAT-4 (bahasa Inggris: signal transducer and activator of transcription 4, SLEB11, STAT4) adalah salah satu faktor transkripsi dari keluarga protein STAT. Protein ini sangat berperan sebagai mediasi respon IL-12 terhadap limfosit, dan diferensiasi sel TH. (in) STAT4 (acronimo in lingua inglese di signal transducer and activator of transcription 4 o trasduttore e attivatore del segnale di trascrizione 4) è un gene umano. La proteina codificata è una delle proteine STAT della famiglia dei fattori di trascrizione. (it) STAT4是转录因子中信号转导及转录激活蛋白（STAT蛋白）家族的一员。在幼稚CD4+ T cells发育为Th1细胞的过程和细胞响应产生IFN-γ的过程中是必需的。 (zh) STAT4 (англ. Signal transducer and activator of transcription 4) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. Довжина поліпептидного ланцюга білка становить 748 амінокислот, а молекулярна маса — 85 941. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | STAT-4 (in) STAT4 (it) STAT4 (en) STAT4 (uk) STAT4 (zh) |
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