Kaitocephalin (original) (raw)
Kaitocephalin is a non-selective ionotropic glutamate receptor antagonist, meaning it blocks the action of the neurotransmitter glutamate. It is produced by the fungus Eupenicillium shearii. Although similar molecules have been produced synthetically, kaitocephalin is the only known naturally occurring glutamate receptor antagonist. There is some evidence that kaitocephalin can protect the brain and central nervous system, so it is said to have neuroprotective properties. Kaitocephalin protects neurons by inhibiting excitotoxicity, a mechanism which causes cell death by overloading neurons with glutamate. Because of this, it is of interest as a potential scaffold for drug development. Drugs based on kaitocephalin may be useful in treating neurological conditions, including Alzheimer's, amy
| Property | Value |
|---|---|
| dbo:abstract | Kaitocephalin is a non-selective ionotropic glutamate receptor antagonist, meaning it blocks the action of the neurotransmitter glutamate. It is produced by the fungus Eupenicillium shearii. Although similar molecules have been produced synthetically, kaitocephalin is the only known naturally occurring glutamate receptor antagonist. There is some evidence that kaitocephalin can protect the brain and central nervous system, so it is said to have neuroprotective properties. Kaitocephalin protects neurons by inhibiting excitotoxicity, a mechanism which causes cell death by overloading neurons with glutamate. Because of this, it is of interest as a potential scaffold for drug development. Drugs based on kaitocephalin may be useful in treating neurological conditions, including Alzheimer's, amyotrophic lateral sclerosis (ALS), and stroke. (en) |
| dbo:iupacName | (2R,5R)-2-[(1S,2R)-2-Amino-1,3-dihydroxy-3-oxopropyl]-5-[(2S)-2-(3,5-dichloro-4-hydroxybenzamido)-3-hydroxy-3-oxopropyl]pyrrolidine-2-carboxylic acid (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Kaitocephalin.svg?width=300 |
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| dbo:wikiPageRevisionID | 1071825318 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Pyrrolidine dbr:Epilepsy dbr:Metabotropic_glutamate_receptor dbr:Penicillin dbr:University_of_California,_Irvine dbr:Neurotransmitter dbr:NMR_spectroscopy dbc:Amino_acids dbc:Chlorobenzenes dbc:NMDA_receptor_antagonists dbc:Phenols dbr:Competitive_antagonist dbr:Memantine dbr:Fungus dbr:Glutamate_(neurotransmitter) dbr:Mosher's_acid dbr:Apoptosis dbr:Chirality dbr:Stereocenter dbr:Stroke dbr:Receptor_antagonist dbr:Neuroplasticity dbr:CNQX dbr:Ionotropic_glutamate_receptor dbr:Nitrone dbr:Alkyl_halide dbr:Amino_acid dbr:Amyotrophic_lateral_sclerosis dbc:Benzamides dbc:Halogen-containing_natural_products dbc:Neuroprotective_agents dbr:Alzheimer's_disease dbr:Parkinson's_disease dbr:Glutamate_receptor dbr:Ischemic_cascade dbr:Kainate_receptor dbr:AMPA_receptor dbc:AMPA_receptor_antagonists dbr:Quinoxalinedione dbr:Two-dimensional_nuclear_magnetic_resonance_spectroscopy dbr:Stereoselectivity dbr:Neuroprotection dbr:Eupenicillium_shearii dbr:IC50 dbr:Excitotoxicity dbr:NMDA_receptor dbr:Sonication dbr:Ionotropic dbr:Structure-activity_relationship |
| dbp:imagefile | Kaitocephalin.svg (en) |
| dbp:imagesize | 200 (xsd:integer) |
| dbp:pin | -2 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Ionotropic_glutamate_receptor_modulators dbt:Reflist |
| dcterms:subject | dbc:Amino_acids dbc:Chlorobenzenes dbc:NMDA_receptor_antagonists dbc:Phenols dbc:Benzamides dbc:Halogen-containing_natural_products dbc:Neuroprotective_agents dbc:AMPA_receptor_antagonists |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | Kaitocephalin is a non-selective ionotropic glutamate receptor antagonist, meaning it blocks the action of the neurotransmitter glutamate. It is produced by the fungus Eupenicillium shearii. Although similar molecules have been produced synthetically, kaitocephalin is the only known naturally occurring glutamate receptor antagonist. There is some evidence that kaitocephalin can protect the brain and central nervous system, so it is said to have neuroprotective properties. Kaitocephalin protects neurons by inhibiting excitotoxicity, a mechanism which causes cell death by overloading neurons with glutamate. Because of this, it is of interest as a potential scaffold for drug development. Drugs based on kaitocephalin may be useful in treating neurological conditions, including Alzheimer's, amy (en) |
| rdfs:label | Kaitocephalin (en) |
| owl:sameAs | yago-res:Kaitocephalin wikidata:Kaitocephalin https://global.dbpedia.org/id/2YTdc |
| prov:wasDerivedFrom | wikipedia-en:Kaitocephalin?oldid=1071825318&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Kaitocephalin.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Kaitocephalin |
| is dbo:wikiPageWikiLink of | dbr:AMPA_receptor dbr:Eupenicillium_shearii dbr:NMDA_receptor |
| is foaf:primaryTopic of | wikipedia-en:Kaitocephalin |
