| dbo:abstract |
MAPK phosphatases (MKPs) are the largest class of phosphatases involved in down-regulating Mitogen-activated protein kinases (MAPK) signaling. MAPK signalling pathways regulate multiple features of development and homeostasis. This can involve gene regulation, cell proliferation, programmed cell death and stress responses. MAPK phosphatases are therefore important regulator components of these pathways. (en) As MAPK fosfatase são uma classe de fosfatases. Estão envolvidas na sinalização celular via MAP quinases (pt) Фосфатазы митоген-активируемых протеинкиназ (MAPK фосфатазы; MKP) — большой класс фосфатаз, участвующих в ингибировании активности митоген-активируемых протеинкиназ (MAPK) и тушении сигнальных путей MAPK. Сигнальные пути MAPK регулируют многочисленные процессы развития и поддержания гомеостаза, включая регуляцию генов, клеточное деление, програмируемую клеточную смерть и стрессактивируемые ответы. Таким образом, MAPK фосфатазы являются важными регуляторными компонентами этих сигнальных путей. (ru) 蛋白激酶磷酸酶（英語：MAPK phosphatasesare）是一类磷酸酶，涉及MAPK信号传导途径，通过去磷酸化降低信号。蛋白激酶信号通路调节发育和稳态的多种特征。 (zh) |
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dbr:Protein_tyrosine_phosphatase dbr:Homeostasis dbr:Cytoplasm dbr:DUSP1 dbr:DUSP10 dbr:DUSP16 dbr:DUSP2 dbr:DUSP4 dbr:DUSP5 dbr:DUSP6 dbr:DUSP7 dbr:Dephosphorylation dbr:Developmental_biology dbr:Innate_immune_system dbr:MKP5 dbc:Enzymes dbr:Gene_structure dbr:Substrate_(chemistry) dbr:Post-translational_modification dbr:T-cell_receptor dbr:C2_domain dbr:Active_site dbr:Threonine dbr:Tyrosine dbr:Dual-specificity_phosphatase dbc:Cell_signaling dbr:Eukaryotes dbr:Cell_cycle dbr:Cell_nucleus dbr:Cell_signaling dbc:Protein_kinases dbr:Mitogen-activated_protein_kinase dbr:C-Jun_N-terminal_kinases dbr:C-terminus dbr:DUSP8 dbr:Regulatory_site dbr:N-terminus dbr:Phosphatase dbr:P38_mitogen-activated_protein_kinases dbr:Electrostatic_interactions dbr:MAP_kinases dbr:Deacetylate dbr:ERK1 dbr:ERK2 dbr:Lymphoid_Cell dbr:Hematopoietic_cell dbr:JNKs dbr:MKP3 dbr:File:MKPs_role_in_ERK_regulation.jpg dbr:File:The_inactivation_of_MAPKs_by_MKPs.jpg dbr:DUSP9 |
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dbt:Reflist dbt:Protein_tyrosine_phosphatases dbt:Intracellular_signaling_peptides_and_proteins dbt:MAP_kinase_activation |
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dbc:Enzymes dbc:Cell_signaling dbc:Protein_kinases |
| gold:hypernym |
dbr:Phosphatases |
| rdf:type |
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| rdfs:comment |
MAPK phosphatases (MKPs) are the largest class of phosphatases involved in down-regulating Mitogen-activated protein kinases (MAPK) signaling. MAPK signalling pathways regulate multiple features of development and homeostasis. This can involve gene regulation, cell proliferation, programmed cell death and stress responses. MAPK phosphatases are therefore important regulator components of these pathways. (en) As MAPK fosfatase são uma classe de fosfatases. Estão envolvidas na sinalização celular via MAP quinases (pt) Фосфатазы митоген-активируемых протеинкиназ (MAPK фосфатазы; MKP) — большой класс фосфатаз, участвующих в ингибировании активности митоген-активируемых протеинкиназ (MAPK) и тушении сигнальных путей MAPK. Сигнальные пути MAPK регулируют многочисленные процессы развития и поддержания гомеостаза, включая регуляцию генов, клеточное деление, програмируемую клеточную смерть и стрессактивируемые ответы. Таким образом, MAPK фосфатазы являются важными регуляторными компонентами этих сигнальных путей. (ru) 蛋白激酶磷酸酶（英語：MAPK phosphatasesare）是一类磷酸酶，涉及MAPK信号传导途径，通过去磷酸化降低信号。蛋白激酶信号通路调节发育和稳态的多种特征。 (zh) |
| rdfs:label |
MAPK phosphatase (en) MAPK fosfatase (pt) MAPK фосфатазы (ru) 蛋白激酶磷酸酶 (zh) |
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