MAP kinase kinase kinase (original) (raw)
Mitogen Activated Protein (MAP) kinase kinase kinase, MAPKKK (or MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP kinase. Several types of MAPKKK can exist but are mainly characterized by the MAP kinases they activate. MAPKKKs are stimulated by a large range of stimuli, primarily environmental and intracellular stressors. MAPKKK is responsible for various cell functions such as cell proliferation, cell differentiation, and apoptosis. The duration and intensity of signals determine which pathway ensues. Additionally, the use of protein scaffolds helps to place the MAPKKK in close proximity with its substrate to allow for a reaction. Lastly, because MAPKKK is involved in a series of several pathways, it has
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| dbo:abstract | Mitogen Activated Protein (MAP) kinase kinase kinase, MAPKKK (or MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP kinase. Several types of MAPKKK can exist but are mainly characterized by the MAP kinases they activate. MAPKKKs are stimulated by a large range of stimuli, primarily environmental and intracellular stressors. MAPKKK is responsible for various cell functions such as cell proliferation, cell differentiation, and apoptosis. The duration and intensity of signals determine which pathway ensues. Additionally, the use of protein scaffolds helps to place the MAPKKK in close proximity with its substrate to allow for a reaction. Lastly, because MAPKKK is involved in a series of several pathways, it has been used as a therapeutic target for cancer, amyloidosis, and neurodegenerative diseases. In humans, there are at least 19 genes which encode MAP kinase kinase kinases: * MAP3K1 (aka MEKK1) * MAP3K2 (aka MEKK2) * MAP3K3 (aka MEKK3) * MAP3K4 (aka MEKK4) * MAP3K5 (aka ASK1) * (aka ) * MAP3K7 (aka MEKK7) (aka ) * MAP3K8 (aka TPL2 or ) * MAP3K9 * MAP3K10 * MAP3K11 (aka MEKK11) (aka MLK3) * MAP3K12 (aka MUK) * MAP3K13 (aka LZK) * MAP3K14 * MAP3K15 * (aka or TAOK1) * (aka or TAOK2) * MAP3K18 (aka TAO3 or TAOK3) * RAF1 * BRAF * ARAF * ZAK (aka ) (en) La MAP cinasa cinasa cinasa, también llamada MAP3K o MEKK, (número EC 2.7.11.25) es una serina/treonina proteína cinasa específica que actúa en un paso inmediatamente posterior a la MAP cinasa cinasa en la vía de las MAP cinasas. En humanos se han descrito al menos 19 genes que codifican proteínas de esta familia: * MAP3K1 (HGNC MEKK1 ) * * (HGNC MAP3K3 ) * * * * (HGNC MAP3K7 ) * * * MAP3K10 * (HGNC MAP3K11 ) * * * * * * * ARAF * Posiblemente, las MAP3K mejor caracterizadas son los miembros de la familia oncogénica (RAF1, BRAF, ARAF), que son efectores de la señalización mitogénica de Ras, y que activan la ruta ERK1/2, a través de la activación de MEK1 y MEK2. MEKK1 activa a la MAPK8/JNK por fosforilación de su activador SEK1. regula directamente a la MAPK8/JNK y la ruta MAPK/ERK por activación de SEK y MEK1/2, respectivamente; no obstante, no regula la ruta de p38. (TAK1) participa en la regulación de la transcripción por medio del TGF-beta. (es) |
| dbo:ecNumber | 2.7.11.25 |
| dbo:thumbnail | wiki-commons:Special:FilePath/MAPKpathway.jpg?width=300 |
| dbo:wikiPageID | 3659951 (xsd:integer) |
| dbo:wikiPageLength | 9882 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1104975284 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Epidermal_growth_factor_receptor dbr:MAP2K4 dbr:MAP3K1 dbr:MAP3K10 dbr:MAP3K11 dbr:MAP3K12 dbr:MAP3K13 dbr:MAP3K14 dbr:MAP3K15 dbr:MAP3K2 dbr:MAP3K3 dbr:MAP3K4 dbr:MAP3K7 dbr:MAP3K8 dbr:MAP3K9 dbr:MAPK/ERK_pathway dbr:MAP_kinase_kinase_kinase_kinase dbc:EC_2.7.11 dbr:Crohn's_disease dbr:TAOK1 dbr:Apoptosis dbr:BRAF_(gene) dbr:G_protein-coupled_receptor dbr:Alzheimer's_disease dbr:Parkinson's_disease dbr:Upstream_and_downstream_(transduction) dbr:Receptor_tyrosine_kinase dbr:ARAF dbr:ASK1 dbc:Protein_kinases dbr:ZAK dbr:C-Jun_N-terminal_kinases dbr:Polycystic_kidney_disease dbr:Serine/threonine-specific_protein_kinase dbr:TAOK2 dbr:List_of_unusual_biological_names dbr:P38_mitogen-activated_protein_kinases dbr:MAP_kinase dbr:MAP3K5 dbr:MAP_kinase_kinase dbr:RAF1 dbr:TGF-beta dbr:TPL2 dbr:TAO2 dbr:ASK2 dbr:MAP3K16 dbr:MAP3K17 dbr:MLTK dbr:TAK1 dbr:TAO1 dbr:Tpl2 dbr:MAP3K6 |
| dbp:casNumber | 146702 (xsd:integer) |
| dbp:ecNumber | 2.700000 (xsd:double) |
| dbp:iubmbEcNumber | 2 (xsd:integer) |
| dbp:name | Mitogen-activated protein kinase kinase kinase (en) |
| dbp:wikiPageUsesTemplate | dbt:EC_number dbt:Enzymes dbt:Infobox_enzyme dbt:MeshName dbt:Portal_bar dbt:Serine/threonine-specific_protein_kinases dbt:Short_description dbt:MAP_kinase_activation |
| dct:subject | dbc:EC_2.7.11 dbc:Protein_kinases |
| gold:hypernym | dbr:Kinase |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | Mitogen Activated Protein (MAP) kinase kinase kinase, MAPKKK (or MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP kinase. Several types of MAPKKK can exist but are mainly characterized by the MAP kinases they activate. MAPKKKs are stimulated by a large range of stimuli, primarily environmental and intracellular stressors. MAPKKK is responsible for various cell functions such as cell proliferation, cell differentiation, and apoptosis. The duration and intensity of signals determine which pathway ensues. Additionally, the use of protein scaffolds helps to place the MAPKKK in close proximity with its substrate to allow for a reaction. Lastly, because MAPKKK is involved in a series of several pathways, it has (en) La MAP cinasa cinasa cinasa, también llamada MAP3K o MEKK, (número EC 2.7.11.25) es una serina/treonina proteína cinasa específica que actúa en un paso inmediatamente posterior a la MAP cinasa cinasa en la vía de las MAP cinasas. En humanos se han descrito al menos 19 genes que codifican proteínas de esta familia: * MAP3K1 (HGNC MEKK1 ) * * (HGNC MAP3K3 ) * * * * (HGNC MAP3K7 ) * * * MAP3K10 * (HGNC MAP3K11 ) * * * * * * * ARAF * (es) |
| rdfs:label | MAP cinasa cinasa cinasa (es) MAP kinase kinase kinase (en) MAPキナーゼキナーゼキナーゼ (ja) |
| owl:sameAs | freebase:MAP kinase kinase kinase wikidata:MAP kinase kinase kinase dbpedia-es:MAP kinase kinase kinase dbpedia-ja:MAP kinase kinase kinase dbpedia-sh:MAP kinase kinase kinase dbpedia-sr:MAP kinase kinase kinase https://global.dbpedia.org/id/4qhwp |
| prov:wasDerivedFrom | wikipedia-en:MAP_kinase_kinase_kinase?oldid=1104975284&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/MAPKpathway.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:MAP_kinase_kinase_kinase |
| foaf:name | Mitogen-activated protein kinase kinase kinase (en) |
| is dbo:wikiPageRedirects of | dbr:STK28 dbr:Map_kinase_kinase_kinase dbr:MAP3K dbr:MAPKKK dbr:Mitogen-activated_protein_kinase_kinase_kinase dbr:EC_2.7.11.25 dbr:ATP:protein_phosphotransferase_(MAPKKKK-activated) dbr:Mkkk dbr:Mekk dbr:MEKK dbr:MEKK4 |
| is dbo:wikiPageWikiLink of | dbr:MAP2K2 dbr:MAP3K15 dbr:MAP_kinase_kinase_kinase_kinase dbr:STK28 dbr:WNK1 dbr:TAB1 dbr:Stoma dbr:T-cell_receptor dbr:ATG5 dbr:Mitogen-activated_protein_kinase dbr:Aurora_kinase_A dbr:C-Raf dbr:Mitogen-activated_protein_kinase_kinase dbr:TNNI3K dbr:Ethylene_signaling_pathway dbr:List_of_unusual_biological_names dbr:Map_kinase_kinase_kinase dbr:Ste5 dbr:MAP3K dbr:MAPKKK dbr:Mitogen-activated_protein_kinase_kinase_kinase dbr:EC_2.7.11.25 dbr:ATP:protein_phosphotransferase_(MAPKKKK-activated) dbr:Mkkk dbr:Mekk dbr:MEKK dbr:MEKK4 |
| is foaf:primaryTopic of | wikipedia-en:MAP_kinase_kinase_kinase |
