| dbo:abstract |
الميكاميلامين Mecamylamine ('Inversine ) هو مناهض غير انتقائي وغير تنافسي للمستقبلات النيكوتينية الكولينرجية ( نيكوتين أستيل كولين ). (ar) La mécamylamine est une amine bicyclique. Un de ses stéréoisomères est un antagoniste partiel des récepteurs nicotiniques d'acétylcholine, développé comme antidépresseur par AstraZeneca et Targacept sous le nom d'Amplixa (TC-5214). (fr) Mecamylamine (INN, BAN; or mecamylamine hydrochloride (USAN); brand names Inversine, Vecamyl) is a non-selective, non-competitive antagonist of the nicotinic acetylcholine receptors (nAChRs) that was introduced in the 1950s as an antihypertensive drug. In the United States, it was voluntarily withdrawn from the market in 2009 but was brought to market in 2013 as Vecamyl and eventually was marketed by Turing Pharmaceuticals. Chemically, mecamylamine is a secondary aliphatic amine, with a pKaH of 11.2 (en) La mecamilamina è un antagonista non competitivo dei recettori nicotinici. l'assorbimento è difficoltoso, incompleto ed imprevedibile per i suoi composti ammonici quaternari. Attraversa la barriera emato-encefalica e può determinare tremore e confusione È stata utilizzata come bloccante gangliare per la cura dell'ipertensione anche se ora è utilizzata come bloccante gangliare solo per motivi di ricerca. È un bloccante dei recettori nicotinici cerebrali di tipo α3β4. (it) Mekamylamina (łac. mecamylaminum) – organiczny związek chemiczny stosowany jako lek z grupy nieselektywnych antagonistów receptorów nikotynowych. Jest lekiem obniżającym ciśnienie tętnicze krwi. Ponadto jest wykorzystywany do blokowania ostrych efektów spowodowanych dymem tytoniowym. (pl) |
| dbo:alternativeName |
Inversine, Vecamyl (en) |
| dbo:casNumber |
6147-18-8 |
| dbo:chEMBL |
1398031 |
| dbo:drugbank |
DB00657 |
| dbo:fdaUniiCode |
6EE945D3OK |
| dbo:pubchem |
4032 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Mecamylamine3.svg?width=300 |
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| dbp:atcSuffix |
BB01 (en) |
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11 (xsd:integer) |
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6147 (xsd:integer) |
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1398031 (xsd:integer) |
| dbp:chemspiderid |
5036243 (xsd:integer) |
| dbp:drugbank |
DB00657 (en) |
| dbp:h |
21 (xsd:integer) |
| dbp:iupacName |
-N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine (en) |
| dbp:iupharLigand |
3990 (xsd:integer) |
| dbp:legalStatus |
Rx-only (en) |
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1 (xsd:integer) |
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40.0 |
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4032 (xsd:integer) |
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Oral (en) |
| dbp:smiles |
NC (en) |
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1 (xsd:integer) |
| dbp:stdinchikey |
IMYZQPCYWPFTAG-IQJOONFLSA-N (en) |
| dbp:tradename |
Inversine, Vecamyl (en) |
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6 (xsd:integer) |
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changed (en) |
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| dcterms:subject |
dbc:Amines dbc:Nicotinic_antagonists dbc:Bicyclic_compounds dbc:Withdrawn_drugs |
| gold:hypernym |
dbr:Antagonist |
| rdf:type |
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| rdfs:comment |
الميكاميلامين Mecamylamine ('Inversine ) هو مناهض غير انتقائي وغير تنافسي للمستقبلات النيكوتينية الكولينرجية ( نيكوتين أستيل كولين ). (ar) La mécamylamine est une amine bicyclique. Un de ses stéréoisomères est un antagoniste partiel des récepteurs nicotiniques d'acétylcholine, développé comme antidépresseur par AstraZeneca et Targacept sous le nom d'Amplixa (TC-5214). (fr) Mecamylamine (INN, BAN; or mecamylamine hydrochloride (USAN); brand names Inversine, Vecamyl) is a non-selective, non-competitive antagonist of the nicotinic acetylcholine receptors (nAChRs) that was introduced in the 1950s as an antihypertensive drug. In the United States, it was voluntarily withdrawn from the market in 2009 but was brought to market in 2013 as Vecamyl and eventually was marketed by Turing Pharmaceuticals. Chemically, mecamylamine is a secondary aliphatic amine, with a pKaH of 11.2 (en) La mecamilamina è un antagonista non competitivo dei recettori nicotinici. l'assorbimento è difficoltoso, incompleto ed imprevedibile per i suoi composti ammonici quaternari. Attraversa la barriera emato-encefalica e può determinare tremore e confusione È stata utilizzata come bloccante gangliare per la cura dell'ipertensione anche se ora è utilizzata come bloccante gangliare solo per motivi di ricerca. È un bloccante dei recettori nicotinici cerebrali di tipo α3β4. (it) Mekamylamina (łac. mecamylaminum) – organiczny związek chemiczny stosowany jako lek z grupy nieselektywnych antagonistów receptorów nikotynowych. Jest lekiem obniżającym ciśnienie tętnicze krwi. Ponadto jest wykorzystywany do blokowania ostrych efektów spowodowanych dymem tytoniowym. (pl) |
| rdfs:label |
ميكاميلامين (ar) Mécamylamine (fr) Mecamilamina (it) Mecamylamine (en) Mekamylamina (pl) |
| owl:sameAs |
freebase:Mecamylamine yago-res:Mecamylamine http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00657 http://www4.wiwiss.fu-berlin.de/sider/resource/drugs/4032 wikidata:Mecamylamine dbpedia-ar:Mecamylamine dbpedia-cy:Mecamylamine dbpedia-fa:Mecamylamine dbpedia-fr:Mecamylamine dbpedia-it:Mecamylamine dbpedia-pl:Mecamylamine dbpedia-ro:Mecamylamine dbpedia-sh:Mecamylamine dbpedia-sr:Mecamylamine https://global.dbpedia.org/id/359Ff |
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wikipedia-en:Mecamylamine?oldid=1113565188&ns=0 |
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wiki-commons:Special:FilePath/Mecamylamine3.svg |
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wikipedia-en:Mecamylamine |
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dbr:C11H21N dbr:ATC_code_C02BB01 dbr:ATCvet_code_QC02BB01 dbr:Mecamylamine_hydrochloride dbr:Inversine dbr:Vecamyl dbr:Amplixa dbr:TC-5214 |
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dbr:Pseudoephedrine dbr:Antihypertensive_drug dbr:List_of_MeSH_codes_(D02) dbr:Pempidine dbr:Phantasmidine dbr:Psychotropic_alkylamines dbr:List_of_investigational_attention_deficit_hyperactivity_disorder_drugs dbr:Smoking_cessation dbr:Epibatidine dbr:Nalfurafine dbr:Conditioned_place_preference dbr:Anticholinergic dbr:Management_of_Tourette_syndrome dbr:C11H21N dbr:Vyera_Pharmaceuticals dbr:Ganglionic_blocker dbr:Alpha-3_beta-2_nicotinic_receptor dbr:Alpha-3_beta-4_nicotinic_receptor dbr:Alpha-4_beta-2_nicotinic_receptor dbr:Nicotinic_antagonist dbr:Glossitis dbr:ATC_code_C02BB01 dbr:ATCvet_code_QC02BB01 dbr:ATC_code_C02 dbr:Acetylcholine_receptor dbr:CHRNA3 dbr:CHRNA6 dbr:Mecamylamine_hydrochloride dbr:Nicotinic_acetylcholine_receptor dbr:Sympatholytic dbr:Inversine dbr:List_of_drugs:_Me–Meo dbr:Vecamyl dbr:Amplixa dbr:TC-5214 |
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