| dbo:abstract |
miR-146 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference. miR-146 is primarily involved in the regulation of inflammation and other process that function in the innate immune system. Loss of functional miR-146 (and mir-145) could predispose an individual to suffer from chromosome 5q deletion syndrome. miR-146 has also been reported to be highly upregulated in osteoarthritis cartilage, and could be involved in its pathogenesis. mir-146 expression is associated with survival in triple negative breast cancer. (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Mir-146_SS.png?width=300 |
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33011955 (xsd:integer) |
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7221 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1116916622 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:MicroRNA dbr:Nucleotide dbc:MicroRNA dbr:Human dbr:Cytokine dbr:Inflammation dbr:Innate_immune_system dbr:RNA_interference dbr:Chromosome_5q_deletion_syndrome dbr:Mammal dbr:Mammalia dbr:Toll-like_receptor dbr:Tumor_necrosis_factor-alpha dbr:Mir-145 dbr:Osteoarthritis dbr:Dicer dbr:RNA-induced_silencing_complex dbr:Biomarker dbr:Pathogenesis dbr:Sepsis dbr:Mir-155 dbr:Secondary_structure dbr:MiRNA dbr:Interleukin_1 |
| dbp:altsymbols |
MIR146 (en) |
| dbp:arm |
q (en) |
| dbp:band |
34 (xsd:integer) |
| dbp:caption |
Conserved secondary structure of miR-146 microRNA precursor (en) |
| dbp:chromosome |
5 (xsd:integer) |
| dbp:entrezgene |
406938 (xsd:integer) |
| dbp:go |
35195 (xsd:integer) |
| dbp:hgncid |
31533 (xsd:integer) |
| dbp:id |
RF00691 (en) |
| dbp:mirbase |
MI0000477 (en) |
| dbp:mirbaseFamily |
MIPF0000103 (en) |
| dbp:name |
miR-146 (en) microRNA mir-146 (en) |
| dbp:omim |
610566 (xsd:integer) |
| dbp:refseq |
NR_029897 (en) |
| dbp:rfam |
RF00691 (en) |
| dbp:rnaType |
miRNA (en) |
| dbp:so |
1244 (xsd:integer) |
| dbp:symbol |
miR-146 (en) |
| dbp:taxDomain |
dbr:Mammalia |
| dbp:wikiPageUsesTemplate |
dbt:Cite_journal dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:Infobox_rfam dbt:Lowercase dbt:Rfam dbt:MiRNA_precursor_families |
| dct:subject |
dbc:MicroRNA |
| gold:hypernym |
dbr:Family |
| rdfs:comment |
miR-146 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference. (en) |
| rdfs:label |
MiR-146 (en) |
| owl:sameAs |
freebase:MiR-146 wikidata:MiR-146 https://global.dbpedia.org/id/4rps1 |
| prov:wasDerivedFrom |
wikipedia-en:MiR-146?oldid=1116916622&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Mir-146_SS.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:MiR-146 |
| is dbo:wikiPageRedirects of |
dbr:Mir146 |
| is dbo:wikiPageWikiLink of |
dbr:Chromosome_5q_deletion_syndrome dbr:Mir146 |
| is foaf:primaryTopic of |
wikipedia-en:MiR-146 |
