| dbo:abstract |
Mixed-phenotype acute leukemia (MPAL) is a group of blood cancers (leukemia) which have combined features of myeloid and lymphoid cancers. It is a rare disease, constituting about 2–5% of all leukemia cases. It mostly involve myeloid with either of T lymphocyte or B lymphocyte progenitors, but in rare cases all the three cell lineages. Knowledge on the cause, clinical features and cellular mechanism is poor, making the treatment and management (prognosis) difficult. The name "mixed-phenotype acute leukemia" was adopted by the World Health Organization in 2008 to include leukemias of ambiguous lineage, acute undifferentiated leukemias and natural killer lymphoblastic leukemias. According to WHO criteria, myeloid lineage is characterised by the presence of myeloperoxidase, while B and T lymphoid lineages are indicated by the expression of CD19 and cytoplasmic CD3. (en) La leucemia a fenotipo misto o a linee miste è una condizione di leucemia acuta dove sono presenti cellule tumorali sia della linea mieloide (leucemia mieloide acuta) che della linea linfoide (leucemia linfoblastica acuta). La definizione clinica raggruppa i vari quadri di leucemia con lineage ambiguo, leucemie acute indifferenziate e leucemie acute linfoblastiche natural-killer. L'origine mieloide è confermata dalla presenza delle mieloperossidasi nelle cellule proliferanti. (it) |
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dbr:Monoclonal_antibodies dbr:Myeloid_leukemia dbr:Leonard_Findlay dbr:Leukemia dbr:Sidney_&_Lois_Eskenazi_Hospital dbr:Philadelphia_chromosome dbc:Acute_leukemia dbr:Western_Infirmary dbr:Cell_death dbr:Chromosomal_inversion dbr:Chromosomal_translocation dbr:Histone_methylation dbr:KMT2A dbr:B_cell dbc:Hematologic_malignant_neoplasms dbr:CD19 dbr:CD3_(immunology) dbr:St._Jude_Children's_Research_Hospital dbr:HOX_genes dbr:World_Health_Organization dbr:Myeloperoxidase dbr:Lymphoid_leukemia dbr:T_cell dbr:Tyrosine_kinase dbr:Proto-oncogene dbr:Histone_methyltransferases |
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| rdfs:comment |
La leucemia a fenotipo misto o a linee miste è una condizione di leucemia acuta dove sono presenti cellule tumorali sia della linea mieloide (leucemia mieloide acuta) che della linea linfoide (leucemia linfoblastica acuta). La definizione clinica raggruppa i vari quadri di leucemia con lineage ambiguo, leucemie acute indifferenziate e leucemie acute linfoblastiche natural-killer. L'origine mieloide è confermata dalla presenza delle mieloperossidasi nelle cellule proliferanti. (it) Mixed-phenotype acute leukemia (MPAL) is a group of blood cancers (leukemia) which have combined features of myeloid and lymphoid cancers. It is a rare disease, constituting about 2–5% of all leukemia cases. It mostly involve myeloid with either of T lymphocyte or B lymphocyte progenitors, but in rare cases all the three cell lineages. Knowledge on the cause, clinical features and cellular mechanism is poor, making the treatment and management (prognosis) difficult. (en) |
| rdfs:label |
Leucemia a lineage ambiguo (it) Mixed-phenotype acute leukemia (en) |
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